DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12951 and PRSS53

DIOPT Version :9

Sequence 1:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	322	Identity:	69/322 - (21%)
Similarity:	118/322 - (36%)	Gaps:	86/322 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVILAVTTV------------GQAAPSISRVVNGTDSSVLKYPFVVSLRSYDGSHSCGGSIISKH 64
            ::::|..||            ||..|...:...| ::...::|:..|:|. .|:|.|.||:::..
Human     8 VLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEG-NTVPGEWPWQASVRR-QGAHICSGSLVADT 70

  Fly    65 FVMTAAHCTNGRPADTL---SIQFGVTNISAMGPNV--VGIKKIIQHEDFDPTRQNANDISLLMV 124
            :|:|||||.....|..|   |:..|......:.|..  ||:..:.....::...| .:|::||.:
Human    71 WVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQ-GSDLALLQL 134

  Fly   125 EEPFEFDGVSVAPVELPALAFAVPQSDAGVEGVLIGWGLNDTYGS-------------------- 169
            ..|     .:..|:.||..|...|   .|......||..:.:.|.
Human   135 AHP-----TTHTPLCLPQPAHRFP---FGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSA 191

  Fly   170 -------------------------VQDTLQEVSLKIYSDEECT-------SRHNGQTDPKYHIC 202
                                     ...||:.:.|::.|...|.       .||.........:|
Human   192 PNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLC 256

  Fly   203 GGVDEGGKGQCSGDSGGPLIY---NGQ--QVGIVSWSIKPCTVAPYPGVYCKVSQYVDWIKS 259
            ||...|.:|.|.||||||::.   :|.  |.||:|:: ..|.....|.:....:.:..|:::
Human   257 GGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFA-SSCAQEDAPVLLTNTAAHSSWLQA 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	62/289 (21%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	63/292 (22%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	62/284 (22%)
		Tryp_SPc	43..314	CDD:214473	61/281 (22%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.110