DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12951 and tmprss6

DIOPT Version :9

Sequence 1:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	242	Identity:	69/242 - (28%)
Similarity:	122/242 - (50%)	Gaps:	19/242 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RVVNGTDSSVLKYPFVVSLRSYDGSHSCGGSIISKHFVMTAAHC----TNGRPADTLSIQFGVTN 89
            |:|.||.:...::|:..||: ..|.|.|||::::..:::|||||    :...| :..::..|...
Frog   570 RLVGGTQAQEGEWPWQASLQ-VRGEHICGGTLVADQWILTAAHCFTPESYASP-EVWTVYLGKVR 632

  Fly    90 ISAMGPNVVGIK--KIIQHEDFDPTRQNANDISLLMVEEPFEFDGVSVAPVELPALAFAVPQSDA 152
            :|......:..|  :::.|..:|....: .|::|::::.........|.|:.||:.....|   .
Frog   633 LSRSTQKELAFKVIRLVIHPFYDEDSHD-YDVALVLLDHLVPLTSPHVQPICLPSSTHHFP---T 693

  Fly   153 GVEGVLIGWGLNDTYGSVQDTLQEVSLKIYSDEECTSRHNGQTDPKYHICGGVDEGGKGQCSGDS 217
            |....:.|||.....|...|.||:|.:::.:.:.||..:..|..|:. :|.|..:|.|..|.|||
Frog   694 GSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDICTELYRYQISPRM-LCAGYRDGSKDACQGDS 757

  Fly   218 GGPLI---YNGQ--QVGIVSWSIKPCTVAPYPGVYCKVSQYVDWIKS 259
            |.||:   .:|:  |.|:|||. ..|.:..|.|||.::::.|.||:|
Frog   758 GSPLVCKTASGRWFQAGLVSWG-AGCGIPRYFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	66/238 (28%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	68/241 (28%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	68/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920