DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and VCL1

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_565879.1	Gene:	VCL1 / 818380	AraportID:	AT2G38020	Length:	858	Species:	Arabidopsis thaliana

Alignment Length:	857	Identity:	252/857 - (29%)
Similarity:	433/857 - (50%)	Gaps:	71/857 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EWFKVRPDYYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKG-NARPMIRIFD 72
            ||..:...||||.|:....|. .:||....|..|.:|||:||.||.:|:|.:.. :|...:|||:
plant     9 EWQLLYDRYYRKPEIYQMKWK-HVDLSRNKVACASFGGPIAVIRDDSKIVQLYAESALRKLRIFN 72

  Fly    73 TTGREMGHILWNH--GKLIAMGWSDMEELICIQENATVFVYDMFGREKE-SYSIGDEASVTKIVE 134
            :.|..:...:|.|  |:||.|.|||.:.||||.::.|::.|::.....| :.|:|.|.....:||
plant    73 SAGILLSETVWKHPGGRLIGMSWSDDQTLICIVQDGTIYRYNIHAELIEPNMSMGQECFEQNVVE 137

  Fly   135 GKVFQSSAGTGVAVMTTSGR-VFLKQNSSKTERKLPDIPNSSMNCSCWEI-VTEGRNSYCLLGRD 197
             .||.   |.||..:|..|: :.:....:....||||:|..:.:.....| :|.....|.:.|..
plant   138 -CVFW---GNGVVCLTEGGQLICIFDFKTMKPSKLPDVPGLAEDDLLQPICLTVREPKYTMSGIA 198

  Fly   198 REVIKLFPGETVGTITANL-----FEKPHER---------------IIKISVSYNHQHLALYTNT 242
            ..::.:  |:.:..:..::     |::|...               :.|:.||.|.:.|.|:|:.
plant   199 EVLVAV--GDDIFVVEEDMVQTIRFDEPSVDDSEMQNDDSGNLIGVVQKMIVSPNGKFLTLFTHD 261

  Fly   243 GLLWLGSVDMRQKYCEFDTGRKDM--PLQMEWIMNSDNSEADAVVISYPSYLLIVNRNADRSDFP 305
            |.:.:  |||..|....|...:..  |.||.|      ...|:|::.:...|::|....|...:.
plant   262 GRIVV--VDMETKQIAIDYSCESALPPQQMAW------CGMDSVLLYWDEDLMMVGPVGDPVHYF 318

  Fly   306 YDPVMFLVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSYKSDEYL 370
            ||..:.|:.|.|||||::.::.|.:||:|...|:||.:.|..||:.|::|...|:.:|.|:||.|
plant   319 YDEPIILIPECDGVRILSNTNLEFLQRVPDSTESIFKIGSTSPAALLYDALDHFDRRSAKADENL 383

  Fly   371 SMCREKIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHE 435
            .:.|..:..||..||:||.:||....|::|||.|.:|:.|..|...:......|.|||||.:|..
plant   384 RLIRSSLSEAVESCIDAAGHEFDVTRQRALLRAASYGQAFCSNFQRERVQETCRTLRVLNAVRDP 448

  Fly   436 RIAMPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPESWILEHWAYHKVMNDPN--DTE 498
            .|.:|::.:|:..|...|::|||:....:.:|::::::|::.:..::.|||..|:...|:  |:.
plant   449 AIGIPLSIQQYKLLTPVVLISRLINANCHLLALRISEYLDMNKEVVIMHWACAKITASPSTPDSH 513

  Fly   499 VARKITEKFKNPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSA 563
            :...:.:|.:  ..:|||:..:|:.|...||..||..|:|.|.|::..|||||.:.:.|.|:..|
plant   514 LLEILLDKLQ--LCKGISYAAVATHADNCGRRKLAAMLVEHEPRSTKQVPLLLSIGEEDTALVKA 576

  Fly   564 TQSGDTELITQVLLEMKMHMMLSNLHMTIRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQKAIA 628
            |:||||:|:..|:..:............|:...||.:::....|......|...:.:...   |.
plant   577 TESGDTDLVYLVIFHIWQKRPPLEFFAMIQGRVLARDLFVAYARCHKHEFLKDFFLSTGQ---IH 638

  Fly   629 EYHF----------QNAIETEGLESN------LSMIGNAYAQGR-CTLEAELCADTSRLIKLQKT 676
            |..|          :|.:.::|...:      :....|.::|.: .|.|::...:.::|:|:|..
plant   639 EVAFLLWKESWDMGKNPMASKGSPLHGPRIKLIEKARNLFSQTKEHTFESKAAEEHAKLLKIQHE 703

  Fly   677 L--STKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELEK 739
            |  |||..:.::. ||::||:..:::|..:.|.::::||||.|:|::||:...|::...|..|||
plant   704 LEASTKQAIFVDS-SINDTIRTCIVLGNNRAAIKVKTEFKVSDKRWYWLKAFALATIKDWAALEK 767

  Fly   740 LAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCRD-NRRVVWYMRANLFNEAIDSAFEQRDVHS 803
            .:|.|:.|:|:.||||.|:..|...||.||||:..| ..|...|.|..:..||.|.|.:..|...
plant   768 FSKEKRPPMGFRPFVEACIDADEKAEALKYIPKLSDLVERGEAYARIGMAKEAADCAAQANDGGE 832

  Fly   804 LFELQKNQAIVN 815
            |.|..:...:.|
plant   833 LLERFRKTFVQN 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	132/439 (30%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	95/321 (30%)
VCL1	NP_565879.1	Vps16_N	8..427	CDD:252829	131/432 (30%)
VCL1	NP_565879.1	Vps16_C	528..835	CDD:282668	93/310 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1092
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7116
Inparanoid	1	1.050	345	1.000	Inparanoid score	I631
OMA	1	1.010	-	-		QHG54061
OrthoDB	1	1.010	-	-		D1258856at2759
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto3192
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840