DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and vps16

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001091659.1	Gene:	vps16 / 798985	ZFINID:	ZDB-GENE-050809-9	Length:	835	Species:	Danio rerio

Alignment Length:	806	Identity:	291/806 - (36%)
Similarity:	482/806 - (59%)	Gaps:	20/806 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TGEWFKVRPDYYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKGNARPMIRIF 71
            |..|..:...:|||:||....|.|...|:......||||||:|:.:...:..|   :|||.:.|:
Zfish     5 TANWNPLGEAFYRKIELYEMAWKLKDGLKDCLFAAAPYGGPIALLKWHNRRSP---SARPQLEIY 66

  Fly    72 DTTGREMGHILWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGK 136
            .::|..:....|..|.:..:||:..::|:|:||:.||.|||:.|..|..:|:|:|.|.::::|.|
Zfish    67 SSSGLPLASFPWKSGVVKQLGWTVSDDLLCVQEDGTVLVYDLLGGFKRHFSMGNEVSQSQVLETK 131

  Fly   137 VFQSSAGTGVAVMTTSGRVFLKQNSSKTE-RKLPDIPNSSMNCSCWEIVTEGRNSYCLLGRDREV 200
            :|.|..|||||::|.:.|..|..|....: |:||::|......|||.::|:.|.|..|:.....:
Zfish   132 IFHSPYGTGVAILTGALRFTLATNIDDIKLRRLPEVPGIQAAPSCWAVLTQDRQSKVLVASGAHL 196

  Fly   201 IKLFPGETVGT-ITANLFEKPHERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTGRK 264
            ..|  ..|..| :|..........|:.:.||:::::|||.|::|.:|:|:.::::|..|.:|..|
Zfish   197 FIL--DNTACTPVTPPGLSPQASSILHMCVSFSYKYLALLTDSGHVWMGTSNLKEKLSEVETKIK 259

  Fly   265 DMPLQMEWIMNSDNSEADAVVISYPSYLLIVNRNADRSDFPYDPVMFLVAEMDGVRIITQSSHEI 329
            ..|.||.|.....:.|..|||: :...||:|....:...:..|....||.|:||||||:.:.||:
Zfish   260 TPPRQMAWCRRPKSQEPSAVVM-WDGLLLVVGECKETIQYQLDDDSILVPELDGVRIISGTHHEL 323

  Fly   330 IQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCREK--IDLAVSECIEAASYEF 392
            :|.:|...|.||.:.|..|.:.|.||.|::|::|.|:||||...:|:  :..||.:|:|||.:|.
Zfish   324 LQEVPGACEEIFKIASMAPGALLLEAHKEYEKESQKADEYLREIKEQSLLSEAVQQCVEAAGHEH 388

  Fly   393 CPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHERIAMPITFKQFSHLNTEVILSR 457
            .|||||:|||.|.|||.|:.|..|::::.:.|.|||||.:|...|.:|:|..||..:..:|::.|
Zfish   389 EPETQKTLLRAASFGKCFLSNFPPEQFVSMCRDLRVLNAVRDYTIGIPLTHTQFKQMTVQVLIDR 453

  Fly   458 LVFRKHYAIAIQVAKHLNLPE----SWILEHWAYHKV-MNDPNDTEVARKITEKFKNPSVEGISF 517
            ||:||.|.:||:|.::|..||    |.:|:|||..|| ..:.:|..:|:.::.|..:.:  |||:
Zfish   454 LVYRKLYPLAIEVCRYLKTPEYQGVSRVLKHWACFKVQQKEESDEVIAKAVSVKLADAA--GISY 516

  Fly   518 CNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMH 582
            ..||:||:::||.:|||||||.|.|:...|||||||:|...|:..|.:||||:|:..|::.:|..
Zfish   517 SEIATKAYESGRTELAIKLLEFEPRSGEQVPLLLKMKKSPLALSKAIESGDTDLVYTVVMYLKNE 581

  Fly   583 MMLSNLHMTIRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQKAIAEYHFQNAIETEGLESNLSM 647
            :...:..|.:|:.|:||::|::..:...:..|..::|.:||.:.:..::.:.:.:.:.||:.:::
Zfish   582 LNRGDFFMMLRNQPVALSLYRQFCKHQEQDTLKDLFNQDDDHEELGNFYVKASYKEQRLEARIAL 646

  Fly   648 IGNA---YAQGRCTLEAELCADTSRLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERI 709
            :.:|   |.:.:....|:...|..||::.|:.|..:....|.|.|:|:|:..||.:|..|.||::
Zfish   647 LQSAVDEYYKAKNEFSAKSTEDEMRLLRFQRKLEEEKGEPLVGFSLHDTMTTLLSVGLHKHAEQL 711

  Fly   710 RSEFKVPDRRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCR 774
            ..:|:|||:|||||::..|:.:..|:||||.||||||||||.|||:||:|..|..|||||:.:..
Zfish   712 YKDFRVPDKRFWWLKLKALAEKEDWDELEKFAKSKKSPIGYLPFVDVCIKHHNKYEARKYVSKVT 776

  Fly   775 DNRRVVWYMRANLFNEAIDSAFEQRD 800
            ..::|..::.......|.::|.|:|:
Zfish   777 PEQKVKAHLAVGDMEGAAEAAIERRN 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	148/417 (35%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	107/289 (37%)
vps16	NP_001091659.1	Vps16_N	5..416	CDD:252829	148/416 (36%)
vps16	NP_001091659.1	Vps16_C	514..830	CDD:282668	107/289 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594214
Domainoid	1	1.000	269	1.000	Domainoid score	I1808
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7116
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1139
OMA	1	1.010	-	-		QHG54061
OrthoDB	1	1.010	-	-		D1258856at2759
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto41437
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1643
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800