DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and VPS16

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_072097.2	Gene:	VPS16 / 64601	HGNCID:	14584	Length:	839	Species:	Homo sapiens

Alignment Length:	821	Identity:	295/821 - (35%)
Similarity:	480/821 - (58%)	Gaps:	21/821 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKGNARPMIRIFDTTGREMGHI 81
            :|||.||.:.||.|..:|....|..||||||:|:.|:|.:.... .:.||::.|:..:|..:..:
Human    16 FYRKYELYSMDWDLKEELRDCLVAAAPYGGPIALLRNPWRKEKA-ASVRPVLDIYSASGMPLASL 79

  Fly    82 LWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGKVFQSSAGTGV 146
            ||..|.::::|||..|||:|:||:..|.||.:.|..:..:|:|:|....::::.::|.:..|:||
Human    80 LWKSGPVVSLGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGV 144

  Fly   147 AVMTTSGRVFLKQNSSKTE-RKLPDIPNSSMNCSCWEIVTEGRNSYCLL--GRDREVIKLFPGET 208
            |::|.:.|..|..|....: |::|::|......|||.::.:.|.::.||  |.|   :.|.....
Human   145 AILTGAHRFTLSANVGDLKLRRMPEVPGLQSAPSCWTVLCQDRVAHILLAVGPD---LYLLDHAA 206

  Fly   209 VGTITANLFEKPHERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTGRKDMPLQMEWI 273
            ...:|...........::::||:.::||||:|:||.:|:|:..:::|.|||:...:..|.||.|
Human   207 CSAVTPPGLAPGVSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVW- 270

  Fly   274 MNSDNSEADAVVISYPSYLLIVNRNADRSDFPYDPVMFLVAEMDGVRIITQSSHEIIQRLPKCVE 338
            .:...|:..|||:::...|::|....:...|..|...:||.|:|||||.::|:||.:..:|...|
Human   271 CSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPAASE 335

  Fly   339 NIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCRE--KIDLAVSECIEAASYEFCPETQKSLL 401
            .||.:.|..|.:.|.||||::|::|.|:||||...:|  ::..||.:|||||.:|..|:.|||||
Human   336 EIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLTQAVQQCIEAAGHEHQPDMQKSLL 400

  Fly   402 RTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHERIAMPITFKQFSHLNTEVILSRLVFRKHYAI 466
            |.|.|||.|:....||.::.:.:.|||||.:|...|.:|:|:.|:..|..:|:|.|||.|:.|.:
Human   401 RAASFGKCFLDRFPPDSFVHMCQDLRVLNAVRDYHIGIPLTYSQYKQLTIQVLLDRLVLRRLYPL 465

  Fly   467 AIQVAKHLNLPE----SWILEHWAYHKV-MNDPNDTEVARKITEKFKNPSVEGISFCNIASKAHQ 526
            |||:.::|.|||    |.||.|||.:|| ..|.:|.:|||.|.:|..:  ..|:|:.:||::|:.
Human   466 AIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGD--TPGVSYSDIAARAYG 528

  Fly   527 AGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMT 591
            .||.:|||||||.|.|:...|||||||::...|:..|.:||||:|:..|||.:|..:...:..||
Human   529 CGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMT 593

  Fly   592 IRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQKAIAEYHFQNAI----ETEGLESNLSMIGNAY 652
            :|:.|:||::|::..:......|..:||.:|:.:.:..:|.:.:.    ..||..:.|....:|:
Human   594 LRNQPMALSLYRQFCKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAF 658

  Fly   653 AQGRCTLEAELCADTSRLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPD 717
            .:.:....|:...|..||::||:.|..:.......||:|:|:..|:|.|..|.||::..:|::||
Human   659 YKAKNEFAAKATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPD 723

  Fly   718 RRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCRDNRRVVWY 782
            :|.|||::..|:....||||||.:|||||||||.||||:|:||.|..||:||..|....::|...
Human   724 KRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGPEQKVKAL 788

  Fly   783 MRANLFNEAIDSAFEQRDVHSLFELQKNQAIVNNGTLLSKV 823
            :......:|.|.|.|.|:...|..:..:.....:|....|:
Human   789 LLVGDVAQAADVAIEHRNEAELSLVLSHCTGATDGATADKI 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	143/408 (35%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	111/313 (35%)
VPS16	NP_072097.2	Vps16_N	4..420	CDD:252829	143/408 (35%)
		Vps16_C	517..835	CDD:282668	111/313 (35%)
		Interaction with VPS33A. /evidence=ECO:0000269\|PubMed:23901104	642..736		29/93 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158294
Domainoid	1	1.000	276	1.000	Domainoid score	I1757
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7116
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1146
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54061
OrthoDB	1	1.010	-	-		D1258856at2759
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto89380
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1643
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800