DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps16A and PTPRA

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001372231.1	Gene:	PTPRA / 5786	HGNCID:	9664	Length:	813	Species:	Homo sapiens

Alignment Length:	158	Identity:	37/158 - (23%)
Similarity:	59/158 - (37%)	Gaps:	34/158 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 KITEKFK--NPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFD------R 558
            |..:|.|  ||...|....:.::...:.|...:...:|::     :|..     ||.|      |
Human   433 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDM-----MHTE-----RKVDVYGFVSR 487

  Fly   559 AVGSATQSGDTEL----ITQVLLEMKMHMMLSNLHMTIRDHPLAL-NIYKKIMRESNRAGLYGIY 618
            ......|...|::    |.|.|||   |.:..:..:.:......| .||.||...||. ||
Human   488 IRAQRCQMVQTDMQYVFIYQALLE---HYLYGDTELEVTSLETHLQKIYNKIPGTSNN-GL---- 544

  Fly   619 NTEDDQKAIAEYHFQN-AIETEGLESNL 645
              |::.|.:.....|| .:.|..|.:|:
Human   545 --EEEFKKLTSIKIQNDKMRTGNLPANM 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	31/143 (22%)
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	21/99 (21%)
PTPRA	NP_001372231.1	R-PTPc-A-2	574..801	CDD:350471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3800
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950