DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and Vps16

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	XP_038960507.1	Gene:	Vps16 / 296159	RGDID:	1359414	Length:	870	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	293/852 - (34%)
Similarity:	482/852 - (56%)	Gaps:	52/852 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKGNARPMIRIFDTTGREMGHI 81
            :|||.||.:.||.|..:|:...|..||||||:|:.|:..:.... .:.||::.::..:|..:..:
  Rat    16 FYRKYELYSMDWDLKEELKDCLVAAAPYGGPIALLRNCWRKEKA-ASVRPVLEMYSASGMPLASL 79

  Fly    82 LWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGKVFQSSAGTGV 146
            ||..|.::|:|||..|||:|:||:..|.||.:.|..:..:|:|:|....::::.::|.:..|:||
  Rat    80 LWKSGPVVALGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGV 144

  Fly   147 AVMTTSGRVFLKQNSSKTE-RKLPDIPNSSMNCSCWEIVTEGRNSYCLL--GRDREVIKLFPGET 208
            |::|.:.|..|..|....: |::|::|......|||..:...|.::.||  |.|   :.|....|
  Rat   145 AILTGAYRFTLSANVGDLKLRRMPEVPGLQSAPSCWTTLCHERVAHILLAVGPD---LYLLDHAT 206

  Fly   209 VGTITANLFEKPHERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTGRKDMPLQMEWI 273
            ...:|...........::::||:.:::|||:|:||.:|:|:..:::|.|||:...:..|.||.|
  Rat   207 CSAVTPAGLAPGVSSFLQMAVSFTYRYLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVW- 270

  Fly   274 MNSDNSEADAVVISYPSYLLIVNRNADRSDFPY-------------------------------D 307
            .:...|:..|||:::...|::|....:...:|:                               |
  Rat   271 CSRPRSKEKAVVVAWERRLMVVGNAPESIQYPWNVSCGLGEGRKRRLPYLWMFLVALTKFRFVLD 335

  Fly   308 PVMFLVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSM 372
            ...:||.|:|||||.::|:||.:..:|...|.||.:.|..|.:.|.||||::|::|.|:||||..
  Rat   336 EDSYLVPELDGVRIFSRSTHEFLHEVPVASEEIFKIASMAPGALLLEAQKEYEKESQKADEYLRE 400

  Fly   373 CRE--KIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHE 435
            .:|  ::..||.:|||||.:|..|:.||.|||.|.|||.|:....||.::.:.:.|||||.:|..
  Rat   401 IQELGQLIQAVQQCIEAAGHEHQPDMQKRLLRAASFGKCFLDRFPPDSFVHMCQDLRVLNAIRDY 465

  Fly   436 RIAMPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPE----SWILEHWAYHKV-MNDPN 495
            .|.:|:|:.|:..|..:|:|.|||.|:.|.:|||:.::|.|||    |.||.|||.:|| ..|.:
  Rat   466 HIGIPLTYTQYKQLTIQVLLDRLVLRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKVQQKDVS 530

  Fly   496 DTEVARKITEKFKNPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFDRAV 560
            |.:|||.|.:|..:  ..|:|:.:||::|:..||.:|||||||.|.|:...|||||||::...|:
  Rat   531 DEDVARAINQKLGD--TPGVSYSDIAARAYGCGRAELAIKLLEYEPRSGEQVPLLLKMKRSKLAL 593

  Fly   561 GSATQSGDTELITQVLLEMKMHMMLSNLHMTIRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQK 625
            ..|.:||||:|:..|||.:|..:...:..||:|:.|:||::|::..:......|..:||.:|:.:
  Rat   594 SKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELDTLKDLYNQDDNHQ 658

  Fly   626 AIAEYHFQNAI----ETEGLESNLSMIGNAYAQGRCTLEAELCADTSRLIKLQKTLSTKYNVSLN 686
            .:..:|.:.:.    ..||..:.|....:|:.:.:....|:...|..||::||:.|..:......
  Rat   659 ELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAKATEDQMRLLRLQRRLEDELGGRFL 723

  Fly   687 GLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYD 751
            .||:|:|:..|:|.|..|.||::..:|::||:|.|||::..|:...:||||||.:|||||||||.
  Rat   724 DLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLSALADLEEWEELEKFSKSKKSPIGYL 788

  Fly   752 PFVEVCLKQDNVMEARKYIPRCRDNRRVVWYMRANLFNEAIDSAFEQRDVHSLFELQKNQAIVNN 816
            ||||:|:||.|..||:||..|....::|...:......:|.|.|.|.|:...|..:..:.....:
  Rat   789 PFVEICMKQHNKHEAKKYASRVGPEQKVKALLLVGDVAQAADVAIEHRNETELSLVLSHCTGTTD 853

  Fly   817 GTLLSKV 823
            |.:..|:
  Rat   854 GAIADKI 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	141/439 (32%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	111/313 (35%)
Vps16	XP_038960507.1	Vps16_N	4..451	CDD:252829	141/439 (32%)
Vps16	XP_038960507.1	Vps16_C	548..866	CDD:282668	111/313 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352277
Domainoid	1	1.000	268	1.000	Domainoid score	I1791
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7116
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG54061
OrthoDB	1	1.010	-	-		D1258856at2759
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto96506
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770