Protein Alignment Vps16A and Vps16

DIOPT Version :10

• Sequence 1: NP_649877.1
• Gene: Vps16A / 41107
• FlyBaseID: FBgn0285911
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_001005541.1
• Gene: Vps16 / 296159
• RGDID: 1359414
• Length: 839
• Species: Rattus norvegicus
• Alignment Length: 821
• Identity: 293/821 - (35%)
• Similarity: 480/821 - (58%)
• Gaps: 21/821 - (2%)

  Fly    17 YYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKGNARPMIRIFDTTGREMGHI 81
            :|||.||.:.||.|..:|:...|..||||||:|:.|:..:.... .:.||::.::..:|..:..:
  Rat    16 FYRKYELYSMDWDLKEELKDCLVAAAPYGGPIALLRNCWRKEKA-ASVRPVLEMYSASGMPLASL 79

  Fly    82 LWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGKVFQSSAGTGV 146
            ||..|.::|:|||..|||:|:||:..|.||.:.|..:..:|:|:|....::::.::|.:..|:||
  Rat    80 LWKSGPVVALGWSAEEELLCVQEDGAVLVYGLHGDFRRHFSMGNEVLQNRVLDARIFHTEFGSGV 144

  Fly   147 AVMTTSGRVFLKQNSSKTE-RKLPDIPNSSMNCSCWEIVTEGRNSYCLL--GRDREVIKLFPGET 208
            |::|.:.|..|..|....: |::|::|......|||..:...|.::.||  |.|   :.|....|
  Rat   145 AILTGAYRFTLSANVGDLKLRRMPEVPGLQSAPSCWTTLCHERVAHILLAVGPD---LYLLDHAT 206

  Fly   209 VGTITANLFEKPHERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTGRKDMPLQMEWI 273
            ...:|...........::::||:.:::|||:|:||.:|:|:..:::|.|||:...:..|.||.|
  Rat   207 CSAVTPAGLAPGVSSFLQMAVSFTYRYLALFTDTGYIWMGTASLKEKLCEFNCNIRAPPKQMVW- 270

  Fly   274 MNSDNSEADAVVISYPSYLLIVNRNADRSDFPYDPVMFLVAEMDGVRIITQSSHEIIQRLPKCVE 338
            .:...|:..|||:::...|::|....:...|..|...:||.|:|||||.::|:||.:..:|...|
  Rat   271 CSRPRSKEKAVVVAWERRLMVVGNAPESIQFVLDEDSYLVPELDGVRIFSRSTHEFLHEVPVASE 335

  Fly   339 NIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCRE--KIDLAVSECIEAASYEFCPETQKSLL 401
            .||.:.|..|.:.|.||||::|::|.|:||||...:|  ::..||.:|||||.:|..|:.||.||
  Rat   336 EIFKIASMAPGALLLEAQKEYEKESQKADEYLREIQELGQLIQAVQQCIEAAGHEHQPDMQKRLL 400

  Fly   402 RTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHERIAMPITFKQFSHLNTEVILSRLVFRKHYAI 466
            |.|.|||.|:....||.::.:.:.|||||.:|...|.:|:|:.|:..|..:|:|.|||.|:.|.:
  Rat   401 RAASFGKCFLDRFPPDSFVHMCQDLRVLNAIRDYHIGIPLTYTQYKQLTIQVLLDRLVLRRLYPL 465

  Fly   467 AIQVAKHLNLPE----SWILEHWAYHKV-MNDPNDTEVARKITEKFKNPSVEGISFCNIASKAHQ 526
            |||:.::|.|||    |.||.|||.:|| ..|.:|.:|||.|.:|..:  ..|:|:.:||::|:.
  Rat   466 AIQICEYLRLPEVQGVSRILAHWACYKVQQKDVSDEDVARAINQKLGD--TPGVSYSDIAARAYG 528

  Fly   527 AGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMT 591
            .||.:|||||||.|.|:...|||||||::...|:..|.:||||:|:..|||.:|..:...:..||
  Rat   529 CGRAELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMT 593

  Fly   592 IRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQKAIAEYHFQNAI----ETEGLESNLSMIGNAY 652
            :|:.|:||::|::..:......|..:||.:|:.:.:..:|.:.:.    ..||..:.|....:|:
  Rat   594 LRNQPMALSLYRQFCKHQELDTLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAF 658

  Fly   653 AQGRCTLEAELCADTSRLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPD 717
            .:.:....|:...|..||::||:.|..:.......||:|:|:..|:|.|..|.||::..:|::||
  Rat   659 YKAKNEFAAKATEDQMRLLRLQRRLEDELGGRFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPD 723

  Fly   718 RRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCRDNRRVVWY 782
            :|.|||::..|:...:||||||.:|||||||||.||||:|:||.|..||:||..|....::|...
  Rat   724 KRLWWLKLSALADLEEWEELEKFSKSKKSPIGYLPFVEICMKQHNKHEAKKYASRVGPEQKVKAL 788

  Fly   783 MRANLFNEAIDSAFEQRDVHSLFELQKNQAIVNNGTLLSKV 823
            :......:|.|.|.|.|:...|..:..:.....:|.:..|:
  Rat   789 LLVGDVAQAADVAIEHRNETELSLVLSHCTGTTDGAIADKI 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	141/408 (35%)
		Vps16_C	515..829	CDD:282668	111/313 (35%)
Vps16	NP_001005541.1	Vps16_N	4..420	CDD:252829	141/408 (35%)
		Vps16_C	517..835	CDD:282668	111/313 (35%)