DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and vps16

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_593444.1	Gene:	vps16 / 2541533	PomBaseID:	SPAC824.05	Length:	835	Species:	Schizosaccharomyces pombe

Alignment Length:	863	Identity:	242/863 - (28%)
Similarity:	428/863 - (49%)	Gaps:	92/863 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IMYNTGEWFKVRPDYYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVP-VKGNARP 66
            |.|...||..::..||:|..:...:|.....:::|:. |||.||.:|:||..:.|.. .|.:..|
pombe     5 IKYPIYEWELLQDTYYQKSAIGKAEWEYIDPVDFMFA-VAPCGGAIAITRSESNLQSNYKYDQVP 68

  Fly    67 M--IRIFDTTGREMGHILWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIG----- 124
            |  |.:|..:|:.:..:.|:...|:.|||::.||||.:.:...|.||::.| |...:|:|
pombe    69 MYSICVFCLSGQLLQTLTWDKTSLVGMGWNENEELIVVSKQGQVRVYNLLG-EFHQFSLGKGVEN 132

  Fly   125 --------DEASVTKIVEGKVFQSSAGTGVAVMTTSGRVFLKQNSSKTERKLPDIPNSSMNCSCW 181
                    .|..|..:::...|.|..|             .::...||...:|.......|...|
pombe   133 IGIRECQFSEGGVFALLQNDTFISITG-------------FEEPWRKTYASIPFNTLEYYNIDSW 184

  Fly   182 EIVTEGRNSYCL-LGRDREVIKLFPGETVGTITANLFEKPH--------ERIIKISVSYNHQHLA 237
            .::.   |.:.. ||.|..|       |||.....:.|:..        :.:..||:|.|.::||
pombe   185 ALIP---NPFSPDLGMDIVV-------TVGPHILQIDEQDSQLHSISSLQHVSHISISPNARYLA 239

  Fly   238 LYTNTGLLWLGSVDMRQKYCEF---DTGRKDMPLQMEWIMNSDNSEADAVVISYPSYLLIVNRNA 299
            ||.:.|.:.:.|.|..::..:.   :|..:....||.|..|      ||||:.:.:.|.:|....
pombe   240 LYESVGKVRVISSDFSKELLDLRLPETVAEASLKQMAWCGN------DAVVLVHENLLTLVGPFG 298

  Fly   300 DRSDFPYDPVMFLVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSY 364
            ....:.|:....:..|:|||||:|:.|.|.::::|..:||||.:.|:.|.:.|.||.:|.:.||.
pombe   299 GSVPYLYNHTPIVSTEVDGVRILTKDSSEFLRKVPAPLENIFHIGSKTPGAKLVEAFQKMKLKSV 363

  Fly   365 KSDEYLSMCREKIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVL 429
            .:::.|...::::..||..|::|:..||..|.||.||..|..||..:|.:|..||:.:.|.||||
pombe   364 FAEKMLLELKDELHDAVDTCVQASLNEFSIEWQKVLLEAASLGKNSLRMYNHQEYVDVCRELRVL 428

  Fly   430 NTLRHERIAMPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPESWILEHWA--YHKVMN 492
            |..|...:.:.||.:::.||..|.::.|...|:.|.:|:|.:..:.:|..|:...||  |.|..:
pombe   429 NAARDPNVGIYITHEEYLHLGLERLIQRFSCRQLYGLAVQASMWMQIPCDWVYIQWAQTYIKQSS 493

  Fly   493 DPN----DTEVARKITEKFKNPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKM 553
            :|.    |..|.|..:.|:       ||:..||..|:|.||..|:.|||:.|..|...|.|||.|
pombe   494 EPEEVVLDNIVKRLSSRKY-------ISYEKIARTAYQEGRLILSTKLLDFEPLAKHQVMLLLNM 551

  Fly   554 RKFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMTIRDHPLALNIYKKIMRESNRAGLYGIY 618
            ..:::|:....::.|..||..|:|::|..|.:::....:.::|.|:.:|.:..::::|..|:..:
pombe   552 EAYEQALKKVIETMDNNLIIYVVLQIKQQMAIASFFQILNEYPDAVKVYVEFAKKNDRKTLHDFF 616

  Fly   619 NTEDDQKAIAEYHFQNAIETEGLESNLSMIGNA----YAQGRCTLEAELCADTSRLIKLQKTLST 679
            ..:|:::.||....::.::|..:...::.:.:|    ......:||.:...|..:|::||:|...
pombe   617 YQDDNKQGIAVLAVEDTLKTATVNQRITSLKSAAKVCSESKELSLEEKCLGDEIKLLQLQQTYED 681

  Fly   680 KYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELEKLAKS- 743
            ::..:..||:::|.:.:|:.|.:.:.|.::||:|::|::||.||::..|.:...|.::|:.|.|
pombe   682 QFTGNFVGLTVNEVVVKLIQINQTQRANKLRSDFQIPEKRFAWLKLRALVAIRDWVQIEQWAGSM 746

  Fly   744 KKSPIGYDPFVEVCLKQDNVMEARKYIPRCRDNRRVVWYMRANLFNEAIDSAFEQRDVHSLFE-- 806
            ::||||::|||...|...|..||.||||||.....          .|.:|...:..||.|..|
pombe   747 RRSPIGFEPFVTEILSAGNKKEAAKYIPRCTQLTT----------QEKVDMWVQVGDVKSASEEA 801

  Fly   807 -LQKNQAIVNNGTLLSKV 823
             ..|:.:::  |.||.:|
pombe   802 AKSKSGSVL--GDLLERV 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	121/442 (27%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	91/317 (29%)
vps16	NP_593444.1	Vps16_N	8..420	CDD:252829	121/442 (27%)
vps16	NP_593444.1	Vps16_C	513..832	CDD:282668	91/317 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	153	1.000	Domainoid score	I1074
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7116
Inparanoid	1	1.050	334	1.000	Inparanoid score	I506
OMA	1	1.010	-	-		QHG54061
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto100962
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1643
SonicParanoid	1	1.000	-	-		X3256
TreeFam	1	0.960	-	-
	14	13.860