DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps16A and vps-16

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_498411.1	Gene:	vps-16 / 175913	WormBaseID:	WBGene00006516	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	843	Identity:	201/843 - (23%)
Similarity:	371/843 - (44%)	Gaps:	112/843 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YYRKVELATPDWPLDLDLEY-MWVEVAPYGGPLAVTRDPTKLVPVKGNARP---MIRIFDTTGRE 77
            |:.:..|.|.    .|:|:| ::.....:.||:||...|          ||   .|.|...:||.
Worm    32 YFTQEYLRTN----SLNLKYVVYFTACQFSGPIAVAYSP----------RPASWYIWIRTISGRI 82

  Fly    78 MGH-ILWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGKVFQSS 141
            :.. :.:|  :.:.|.|:....|:.:.:.....::...| ||.|..|.| :.::.:.|.:.|.:|
Worm    83 LKRDMAFN--EPVFMEWTRAHCLLVLNKAGRAHIFSSLG-EKISEVIFD-SQMSDVHECRTFATS 143

  Fly   142 AG-TGVAVMTTSGRVFLKQNSSKTERKLPDI-----PNSSMNCSCWEIVTEGRNSYCLLGRDREV 200
            .| :|:|||...|:|.:..:.|:     |.|     |.|.|..:........:.::.||..:...
Worm   144 RGDSGIAVMDVDGQVSVVNSVSE-----PVIWSMKPPYSEMPTAWTAFQPHSQLTHILLIFEAVF 203

  Fly   201 IKLFPGETVGTITANLFEKPH--------ERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYC 257
            :....||       :|.|:.|        .:.:|..|......:|:.|.:|.:.:.|:|:...:|
Worm   204 LMGCQGE-------SLREQSHAASWVDSNTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFC 261

  Fly   258 EFDTGRKDMP--LQMEWIMNSDNSEADAVVISY-PSYLLIVNRNADRSDFPYDPVMF-------- 311
            ..:....|:.  :...|:.||      ||.:.. ||.::.||.:|.|.  |.|.|..
Worm   262 TVEITDHDIAKCINFGWVGNS------AVFVQMSPSLIVFVNVSARRK--PGDEVQIYEKMTANA 318

  Fly   312 -LVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCRE 375
             :..|.||:|:...:..|.::...:....:...|..|..::|::|.::..:.:..:....|...:
Worm   319 KISIEPDGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQ 383

  Fly   376 KIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRNHNPD--EYMRIMRILRVLNTLRHERIA 438
            .:..|:.:||..|...:.||.||.||:.|.||..: .|..||  :.||.::.:||||.||..|..
Worm   384 DLYKAIDDCISTACDTWQPEEQKLLLKAARFGMAY-TNTTPDTTKLMRAIKEIRVLNELRMVRTG 447

  Fly   439 MPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPES----WILEHWAYHKV--------- 490
            :|:|.:||..:....:::||:....|::||:||:.|....|    .:|..|....:
Worm   448 IPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVRRSISKVSKSNMK 512

  Fly   491 MNDPNDTEVARKITEK-FKNPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMR 554
            |:.|....:..||:.| .:.|.|   |..:.|.:|.:|...:||...:..|:..:.||.:||::.
Worm   513 MDQPALEALDEKISAKLLQFPHV---SIADAARRAIEAKLPELARLFIRRETDDANHVAVLLQLN 574

  Fly   555 KFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMTIRDHPLALNIYKKIMRE-------SNRA 612
            ....|:..|:.|...:||.||:..:......|:..:.|...|||..:|:.::|:       |:|.
Worm   575 DVSAALQKASASQRPQLIHQVVRHLMNSESRSSYELAISRIPLAQCLYQDLVRQEGETRGASSRQ 639

  Fly   613 GLYGIYNTEDDQKAIAEYHFQNAIETEGLESNLSMIGN----AYAQGRCTLEAELCADTSRLIKL 673
            .|..:....|.::... :||..|......:..|:.:..    |.:.|...:| |:..|.|....|
Worm   640 MLALLEQASDFERQTL-FHFDVAETERNPDERLNALRRAKDAAKSMGDKAIE-EILNDVSAFAPL 702

  Fly   674 QKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELE 738
            |      .......:|:.:|:.|  :..:..:..:::.:.::.|::.....|..|:.:.|.|:|.
Worm   703 Q------IQRGQADMSVRDTVIE--MAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLF 759

  Fly   739 KLAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCRDNRRVV-WYMRANLFNEAIDSAFEQRD 800
            .||: |:|||||.|||:.|::...:.|.:||..:......:| .::....:.||...|:::||
Worm   760 DLAQ-KRSPIGYAPFVKACVRYKRLDEIKKYFAKVNGYPDLVAAHLAMKNYVEAAKLAYDRRD 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	99/436 (23%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	71/298 (24%)
vps-16	NP_498411.1	Vps16_N	20..430	CDD:252829	99/436 (23%)
vps-16	NP_498411.1	Vps16_C	535..825	CDD:282668	72/301 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165993
Domainoid	1	1.000	71	1.000	Domainoid score	I6198
eggNOG	1	0.900	-	-		E1_KOG2280
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2845
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3800
OMA	1	1.010	-	-		QHG54061
OrthoDB	1	1.010	-	-		D1258856at2759
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto19078
orthoMCL	1	0.900	-	-		OOG6_102133
Panther	1	1.100	-	-	LDO	PTHR12811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1643
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790