DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps16A and caprin2

DIOPT Version :9

Sequence 1:	NP_649877.1	Gene:	Vps16A / 41107	FlyBaseID:	FBgn0285911	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	XP_002942296.3	Gene:	caprin2 / 100145510	XenbaseID:	XB-GENE-1014055	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	250	Identity:	44/250 - (17%)
Similarity:	83/250 - (33%)	Gaps:	91/250 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 ITQSSHEIIQRLPKCVENI-FAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCREKIDLAVSECI 385
            :.|...|.:::..:.|.|: ||...|:..|.|.:...|.::|:.:.:..|.:..||..|
Frog    85 LNQDQQEAVEKYEEVVHNLDFARELQKTFSALSQDLLKAQKKALRREHLLKVEAEKKRL------ 143

  Fly   386 EAASYEFCPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHERIAMPITFKQFSHLN 450
                        |::|:..|......::|...::.            .....|:.::.|...||
Frog   144 ------------KAILQVQYMLHALCQDHVQKDFK------------EGSNGAVSLSPKDTDHL- 183

  Fly   451 TEVILSRLVFRKHYAIAIQVAKHLNLPES--------WILEHWAYHKVMNDPNDTEVARKITEKF 507
              |..::|..:|.|       .|::|.:.        |              |..|.:.|
Frog   184 --VKFAKLTCQKRY-------PHMSLEDQMDQASICLW--------------NLFESSEK----- 220

  Fly   508 KNPSVEGISFCNIASKAHQAGRDDLAIKLLE-----------LESRASLHVPLLL 551
               :|.|.|:..:         .:|..|||:           :|.....|:|.:|
Frog   221 ---TVAGTSYKYL---------KELVTKLLDCGYFENVPEAPVEKAKEKHIPEVL 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps16A	NP_649877.1	Vps16_N	6..421	CDD:252829	19/99 (19%)
Vps16A	NP_649877.1	Vps16_C	515..829	CDD:282668	8/47 (17%)
caprin2	XP_002942296.3	Caprin-1_dimer	129..244	CDD:408102	29/185 (16%)
		Caprin-1_C	477..816	CDD:403488
		C1q	884..1009	CDD:395310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1252
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004640
OrthoInspector	1	1.000	-	-		oto103215
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1643
SonicParanoid	1	1.000	-	-		X3256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.080