Protein Alignment sage and HAND2

DIOPT Version :10

• Sequence 1: NP_524287.1
• Gene: sage / 41105
• FlyBaseID: FBgn0037672
• Length: 268
• Species: Drosophila melanogaster
• Sequence 2: NP_068808.1
• Gene: HAND2 / 9464
• HGNCID: 4808
• Length: 217
• Species: Homo sapiens
• Alignment Length: 188
• Identity: 51/188 - (27%)
• Similarity: 79/188 - (42%)
• Gaps: 51/188 - (27%)

  Fly    66 YTLTADGAGLLAYAPTH-PHSYSPSVMG---GYEKEAHNMGLLPPTYSVIPQPVSMWHAGQVATG 126
            |...|..|...|.|.:. .|..:|...|   |:.:      :.||.||     :::.::.:.|:|
Human    18 YPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPE------MSPPDYS-----MALSYSPEYASG 71

  Fly   127 SPVGLECNK----PSELVPPPMYMSYSGGSIANSTEVDIAKEHNPAWREKALQMEKDYRRTACDR 187
            : .||:.:.    |....||.:     ||.             .|..|          |.||..:
Human    72 A-AGLDHSHYGGVPPGAGPPGL-----GGP-------------RPVKR----------RGTANRK 107

  Fly   188 ERTRMRDMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYINHLQAMLRESSVGQNG 245
            ||.|.:.:|.||..||..:| :.|...|.|||::||:|.:||.:|..:|.:..  |||
Human   108 ERRRTQSINSAFAELRECIP-NVPADTKLSKIKTLRLATSYIAYLMDLLAKDD--QNG 162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	bHLH_TS	181..236	CDD:381396	23/54 (43%)
HAND2	NP_068808.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..116		13/67 (19%)
		bHLH_TS_HAND2	100..161	CDD:381477	25/73 (34%)