Protein Alignment sage and ATOH8

DIOPT Version :10

• Sequence 1: NP_524287.1
• Gene: sage / 41105
• FlyBaseID: FBgn0037672
• Length: 268
• Species: Drosophila melanogaster
• Sequence 2: XP_011531441.1
• Gene: ATOH8 / 84913
• HGNCID: 24126
• Length: 328
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 72/256 - (28%)
• Similarity: 95/256 - (37%)
• Gaps: 61/256 - (23%)

  Fly     2 TDQLLSSTAGVPGDPPPVLVPVSATTGGPYLSGGSE--GEAESSEQPVLLELGAPQSSSCPAVSL 64
            |:.|...|..:...|.||.|||......| ..||::  ||...|.        ||:.|.  |...
Human    57 TNGLRDRTHRLQPVPVPVPVPVPVAPAVP-PRGGTDTAGERGGSR--------APEVSD--ARKR 110

  Fly    65 NYTLTADGAGLLAYAPTHPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPVSMWHAGQVATGSPV 129
            .:.|.|.|.||....|..|.:......||.|.:......|.|...:...|.....:...|..:|
Human   111 CFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP- 174

  Fly   130 GLECNKPSELVPP-----PMYMSYS---------------------GGSIANSTEVDIAKEHNPA 168
                  |...|.|     |...|||                     |.:.|.|:|:
Human   175 ------PESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEI--------- 224

  Fly   169 WREKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYI 229
               ||||..:  |..|..|||||:..::.||:.||.::|... .|:|.||:..||||.|||
Human   225 ---KALQQTR--RLLANARERTRVHTISAAFEALRKQVPCYS-YGQKLSKLAILRIACNYI 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	bHLH_TS	181..236	CDD:381396	23/49 (47%)
ATOH8	XP_011531441.1	bHLH_TS_ATOH8	224..291	CDD:381427	27/71 (38%)