DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sage and Bhlhe22

DIOPT Version :9

Sequence 1:	NP_524287.1	Gene:	sage / 41105	FlyBaseID:	FBgn0037672	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_067535.3	Gene:	Bhlhe22 / 59058	MGIID:	1930001	Length:	355	Species:	Mus musculus

Alignment Length:	279	Identity:	71/279 - (25%)
Similarity:	94/279 - (33%)	Gaps:	102/279 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLSSTAGVPGDPPPVLVPVSAT---TGGPYLSGGSEGEAESSEQ----------PVLLELGAPQS 56
            ||..:|||.|:|....:|..|.   ..|.....||..|:...||          .::|..|.|..
Mouse    97 LLVGSAGVGGEPSLSSLPAGAALCLKYGESAGRGSVAESSGGEQSPDDDSDGRCELVLRAGGPDP 161

  Fly    57 SSCPAVSLNYTLTADGAGLLAYAPTHPHSYSPSVMGGYEKEA--------HNMGLLPPTYSVIPQ 113
            .:.|           |||                 ||..|.|        |....|||
Mouse   162 RASP-----------GAG-----------------GGSAKVAEGCSNAHLHGGSGLPP------- 191

  Fly   114 PVSMWHAGQVATGSPVGLECNKPSELVPPPMYMSYSGGSIANSTEVDIAKEHNPAWREKALQMEK 178
                  .|..:.|...|                 ..|||...|.|            :|||::..
Mouse   192 ------GGPTSGGGSGG-----------------GGGGSSKKSKE------------QKALRLNI 221

  Fly   179 DYRRTACDRERTRMRDMNRAFDLLRSKLPIS-KPNGKKYSKIESLRIAINYI----NHLQAMLRE 238
            :      .|||.||.|:|.|.|.||:.:|.: .|:.:|.|||.:|.:|.|||    ..|:.|.|.
Mouse   222 N------ARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRL 280

  Fly   239 SSVGQNGNGCCAWSGGSSS 257
            .:....|....|.|..||:
Mouse   281 VAYLNQGQAISAASLPSSA 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	HLH	181..233	CDD:278439	22/56 (39%)
Bhlhe22	NP_067535.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..215		28/156 (18%)
		HLH	222..276	CDD:197674	23/59 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810