DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sage and NEUROD4

DIOPT Version :9

Sequence 1:NP_524287.1 Gene:sage / 41105 FlyBaseID:FBgn0037672 Length:268 Species:Drosophila melanogaster
Sequence 2:NP_067014.2 Gene:NEUROD4 / 58158 HGNCID:13802 Length:331 Species:Homo sapiens


Alignment Length:162 Identity:51/162 - (31%)
Similarity:65/162 - (40%) Gaps:44/162 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 ELVPPPMYMSYSGGSIANSTEVD-----------IAKEHNPAWREKALQM--EKDYRR------- 182
            |||..|.:|....||.....|.:           :.:||:....|:..:.  ||..||       
Human    13 ELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKM 77

  Fly   183 -------------TACDRERTRMRDMNRAFDLLRSKLP-ISKPNGKKYSKIESLRIAINYINHLQ 233
                         .|..||||||..:|.|.|.||..:| .||.  :|.||||:||:|.|||..|.
Human    78 TKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT--QKLSKIETLRLARNYIWALS 140

  Fly   234 AMLRESSVGQNGNG----CCAWSGGSSSPYDN 261
            .:| |:.....|.|    .|.   |.|.|..|
Human   141 EVL-ETGQTPEGKGFVEMLCK---GLSQPTSN 168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sageNP_524287.1 HLH 181..233 CDD:278439 28/72 (39%)
NEUROD4NP_067014.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80 15/66 (23%)
HLH 88..144 CDD:238036 28/58 (48%)
Neuro_bHLH 146..264 CDD:289310 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..265
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3898
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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