Protein Alignment sage and ASCL2

DIOPT Version :10

• Sequence 1: NP_524287.1
• Gene: sage / 41105
• FlyBaseID: FBgn0037672
• Length: 268
• Species: Drosophila melanogaster
• Sequence 2: NP_005161.1
• Gene: ASCL2 / 430
• HGNCID: 739
• Length: 193
• Species: Homo sapiens
• Alignment Length: 194
• Identity: 49/194 - (25%)
• Similarity: 72/194 - (37%)
• Gaps: 64/194 - (32%)

  Fly   102 GLLPPTYSVIPQPVSMWHAGQVATGSPVGLECNKPSELVPPPMYMSYSGGSIANSTEVDIAKEHN 166
            |.||.:....| ||.:..|.:....||..|.|::...    |......||:.|      :|:.:
Human     4 GTLPRSAPPAP-PVPVGCAARRRPASPELLRCSRRRR----PATAETGGGAAA------VARRN- 56

  Fly   167 PAWREKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYINH 231
                               :|||.|::.:|..|..||..:|....: ||.||:|:||.|:.||..
Human    57 -------------------ERERNRVKLVNLGFQALRQHVPHGGAS-KKLSKVETLRSAVEYIRA 101

  Fly   232 LQAMLRESSVGQNGNGCCAWSGG---------------------------SSSPYDNGNDHWGA 268
            ||.:|.|....:|     |.:||                           ||||...|:...|:
Human   102 LQRLLAEHDAVRN-----ALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGS 160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	bHLH_TS	181..236	CDD:381396	21/54 (39%)
ASCL2	NP_005161.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..56		5/28 (18%)
		bHLH_TS_ASCL2_Mash2	49..112	CDD:381586	25/89 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..177		8/43 (19%)