DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sage and Neurod2

DIOPT Version :9

Sequence 1:	NP_524287.1	Gene:	sage / 41105	FlyBaseID:	FBgn0037672	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_035025.3	Gene:	Neurod2 / 18013	MGIID:	107755	Length:	383	Species:	Mus musculus

Alignment Length:	183	Identity:	57/183 - (31%)
Similarity:	76/183 - (41%)	Gaps:	32/183 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GLLAYAPTHPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPVSMWHA-GQVATGSPVGLECNKPS 137
            |||:..|    .::....|..::...:.|..||.    |.|.....| |......||.|   :..
Mouse    10 GLLSDVP----KFASWGDGDDDEPRSDKGDAPPQ----PPPAPGSGAPGPARAAKPVSL---RGG 63

  Fly   138 ELVPPPMYMSYS-----GGSIANSTE----VDIAKEHNPAWR--------EKALQMEKDYRRTAC 185
            |.:|.|......     ||......|    :|.|:...|..|        :..|:..|..|:.|.
Mouse    64 EEIPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKAN 128

  Fly   186 DRERTRMRDMNRAFDLLRSKLP-ISKPNGKKYSKIESLRIAINYINHLQAMLR 237
            .|||.||.|:|.|.|.||..:| .||.  :|.||||:||:|.|||..|..:||
Mouse   129 ARERNRMHDLNAALDNLRKVVPCYSKT--QKLSKIETLRLAKNYIWALSEILR 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	HLH	181..233	CDD:278439	27/52 (52%)
Neurod2	NP_035025.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..130		29/130 (22%)
		bHLH_TS_NeuroD2	89..181	CDD:381563	37/93 (40%)
		Nuclear localization signal. /evidence=ECO:0000255	108..114		0/5 (0%)
		Neuro_bHLH	181..311	CDD:372170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810