Protein Alignment sage and Ascl1

DIOPT Version :10

• Sequence 1: NP_524287.1
• Gene: sage / 41105
• FlyBaseID: FBgn0037672
• Length: 268
• Species: Drosophila melanogaster
• Sequence 2: NP_032579.2
• Gene: Ascl1 / 17172
• MGIID: 96919
• Length: 231
• Species: Mus musculus
• Alignment Length: 268
• Identity: 64/268 - (23%)
• Similarity: 89/268 - (33%)
• Gaps: 92/268 - (34%)

  Fly     6 LSSTAGVPGDPP-PVLVPVS---ATTGGPYLSGGSEGEAESSEQPVLLELGAPQSSSCPAVSLNY 66
            :.|.||....|| |.|.|.:   ||......:..:..::...:||......|||.|.
Mouse     7 MESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSP-------- 63

  Fly    67 TLTADGAGLLAYAPTHPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPVSMWHAGQV---ATGSP 128
              .||.              .||  ||..|.|                     |.||   .:.||
Mouse    64 --VADS--------------QPS--GGGHKSA---------------------AKQVKRQRSSSP 89

  Fly   129 VGLECNKPSELVPPPMYMSYSGGSIANSTEVDIAKEHNPAWREKALQMEKDYRRTACDRERTRMR 193
            ..:.|.:       .:..|..|.|:.......:|:.:                    :|||.|::
Mouse    90 ELMRCKR-------RLNFSGFGYSLPQQQPAAVARRN--------------------ERERNRVK 127

  Fly   194 DMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYINHLQAMLRESSVGQNGNGCCAWSGGSSSP 258
            .:|..|..||..:|....| ||.||:|:||.|:.||..||.:|.|.....     .|:..|..||
Mouse   128 LVNLGFATLREHVPNGAAN-KKMSKVETLRSAVEYIRALQQLLDEHDAVS-----AAFQAGVLSP 186

  Fly   259 -----YDN 261
                 |.|
Mouse   187 TISPNYSN 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	bHLH_TS	181..236	CDD:381396	22/54 (41%)
Ascl1	NP_032579.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		7/16 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..92		19/99 (19%)
		bHLH_TS_ASCL1_Mash1	110..180	CDD:381585	26/95 (27%)