DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sage and Neurog2

DIOPT Version :9

Sequence 1:	NP_524287.1	Gene:	sage / 41105	FlyBaseID:	FBgn0037672	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_033848.1	Gene:	Neurog2 / 11924	MGIID:	109619	Length:	263	Species:	Mus musculus

Alignment Length:	149	Identity:	49/149 - (32%)
Similarity:	63/149 - (42%)	Gaps:	42/149 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 AGQVATGSP------------VGL--ECNKPSELVPPPMYMSYSGGSIANSTEVDIAKEHNPAWR 170
            |||...|||            :||  ||.:     .|....:.|.|          ||.     .
Mouse    59 AGQGVQGSPASGAGGCRPGRLLGLMHECKR-----RPSRSRAVSRG----------AKT-----A 103

  Fly   171 EKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYINHLQAM 235
            |...:::|..|..|.:|||.||.::|.|.|.||..|| :.|...|.:|||:||.|.|||..|...
Mouse   104 ETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLP-TFPEDAKLTKIETLRFAHNYIWALTET 167

  Fly   236 LRESSVGQNGNGCCAWSGG 254
            ||.:.       .||.:||
Mouse   168 LRLAD-------HCAGAGG 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sage	NP_524287.1	HLH	181..233	CDD:278439	25/51 (49%)
Neurog2	NP_033848.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..76		6/16 (38%)
		bHLH_TS_NGN2_ATOH4	104..172	CDD:381560	30/68 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810