DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP6AP2 and Atp6ap2

DIOPT Version :9

Sequence 1:	NP_649876.1	Gene:	ATP6AP2 / 41104	FlyBaseID:	FBgn0037671	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001007092.1	Gene:	Atp6ap2 / 302526	RGDID:	1561269	Length:	350	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	95/356 - (26%)
Similarity:	165/356 - (46%)	Gaps:	50/356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VFVIFSLFIAAINASGEFTVLNRPKAISFK-GNDALESHYVGDVLYASMGNAVSGDTNWNGLTIN 67
            |.::.||..:|:  :.||::|..|.::.|: ||..:....:.||...|||.:|..|.:|.||.:.
  Rat     5 VVLLSSLVSSAL--ANEFSILRSPGSVVFRNGNWPIPGDRIPDVAALSMGFSVKEDLSWPGLAVG 67

  Fly    68 DPFNLAKGVILVHVQGIGHVT-TAGNVKTYELTGS---GTDASLNAL----------AAELEAAN 118
            :.|:..:..|:|.|:|:..:. ..|:|.:|.|..:   ..|:..|::          ..:|..:.
  Rat    68 NLFHRPRATIMVTVKGVDKLALPTGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSE 132

  Fly   119 EPVCDIN-----FEQFDDGVQAWKS-CFGDFEAPAAKPTKHLNPS-----LHTADKQFLQEVGFI 172
            |.|..:.     ||.....::..:: .|.:.....:.|...|:.:     |..::.|.|.::..:
  Rat   133 ERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLNSLPLNSLSRNNEVDLLFLSELQVLHDISSL 197

  Fly   173 NSAADHLAEMAKPSNVLMLRVSVDGVAKAHGEKSVAVEEANKLLSAAISRLL------------- 224
            .|...|||:...|....:....:|.:.|.:||.|....:|:::|..|:.:..
  Rat   198 LSRHKHLAKDHSPDLYSLELAGLDELGKRYGEDSEQFRDASRILVDALQKFADDMYSLYGGNAVV 262

  Fly   225 -AASQKSSDSVLFVQTTEKDVAASRAKRDTIAASTTNPYNLAVYYGSDYPVIFNIILWFMVVFGL 288
             ..:.||.|:.|        |..||...:|...:|.:|||||..|..:|.|:||::||.|....|
  Rat   263 ELVTVKSFDTSL--------VRKSRTILETKQENTQSPYNLAYKYNLEYSVVFNLVLWIMTGLAL 319

  Fly   289 SLLAICYAIAAMDPGRDSIIYRMTSTRIKKD 319
            :::...|.|..||||.||||||||:.:|:.|
  Rat   320 AVIITSYNIWNMDPGYDSIIYRMTNQKIRMD 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP6AP2	NP_649876.1	Renin_r	231..319	CDD:369555	36/87 (41%)
Atp6ap2	NP_001007092.1	Renin_r	255..350	CDD:400278	38/102 (37%)
Atp6ap2	NP_001007092.1	Mediates retrograde transport to the ER. /evidence=ECO:0000250\|UniProtKB:O75787	346..350		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338404
Domainoid	1	1.000	73	1.000	Domainoid score	I9033
eggNOG	1	0.900	-	-		E1_KOG4737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38097
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4757
OMA	1	1.010	-	-		QHG48564
OrthoDB	1	1.010	-	-		D1179410at2759
OrthoFinder	1	1.000	-	-		FOG0007261
OrthoInspector	1	1.000	-	-		oto96867
orthoMCL	1	0.900	-	-		OOG6_106424
Panther	1	1.100	-	-	LDO	PTHR13351
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770