DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP6AP2 and ATP6AP2

DIOPT Version :9

Sequence 1:	NP_649876.1	Gene:	ATP6AP2 / 41104	FlyBaseID:	FBgn0037671	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_005756.2	Gene:	ATP6AP2 / 10159	HGNCID:	18305	Length:	350	Species:	Homo sapiens

Alignment Length:	358	Identity:	94/358 - (26%)
Similarity:	168/358 - (46%)	Gaps:	48/358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LRVFVIFSLFIAAINASGEFTVLNRPKAISFK-GNDALESHYVGDVLYASMGNAVSGDTNWNGLT 65
            :.|||:....:|.: ...||::|..|.::.|: ||..:....:.||...|||.:|..|.:|.||.
Human     1 MAVFVVLLALVAGV-LGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLA 64

  Fly    66 INDPFNLAKGVILVHVQGIGHVT-TAGNVKTYELTGS---GTDASLNAL----------AAELEA 116
            :.:.|:..:..::|.|:|:..:. ..|:|.:|.|..:   ..|:..|::          ..:|..
Human    65 VGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAP 129

  Fly   117 ANEPVCDIN-----FEQFDDGVQAWKS-CFGDFEAPAAKPTKHLNPS-----LHTADKQFLQEVG 170
            :.|.|..:.     ||.....::..:: .|.:....::.|...|:.:     |..::.|.|.::.
Human   130 SEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDIS 194

  Fly   171 FINSAADHLAEMAKPSNVLMLRVSVDGVAKAHGEKSVAVEEANKLLSAAISRLL----------- 224
            .:.|...|||:...|....:....:|.:.|.:||.|....:|:|:|..|:.:..
Human   195 SLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNA 259

  Fly   225 ---AASQKSSDSVLFVQTTEKDVAASRAKRDTIAASTTNPYNLAVYYGSDYPVIFNIILWFMVVF 286
               ..:.||.|:.| ::.|...:.|.:||      :..:|||||..|..:|.|:||::||.|:..
Human   260 VVELVTVKSFDTSL-IRKTRTILEAKQAK------NPASPYNLAYKYNFEYSVVFNMVLWIMIAL 317

  Fly   287 GLSLLAICYAIAAMDPGRDSIIYRMTSTRIKKD 319
            .|:::...|.|..||||.||||||||:.:|:.|
Human   318 ALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP6AP2	NP_649876.1	Renin_r	231..319	CDD:369555	35/87 (40%)
ATP6AP2	NP_005756.2	Renin_r	254..350	CDD:400278	30/65 (46%)
ATP6AP2	NP_005756.2	Mediates retrograde transport to the ER. /evidence=ECO:0000269\|PubMed:29127204	346..350

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144708
Domainoid	1	1.000	71	1.000	Domainoid score	I9469
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38097
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48564
OrthoDB	1	1.010	-	-		D1179410at2759
OrthoFinder	1	1.000	-	-		FOG0007261
OrthoInspector	1	1.000	-	-		oto89754
orthoMCL	1	0.900	-	-		OOG6_106424
Panther	1	1.100	-	-	LDO	PTHR13351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4406
SonicParanoid	1	1.000	-	-		X6151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.940