DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16736 and UCP1

DIOPT Version :9

Sequence 1:	NP_649873.1	Gene:	CG16736 / 41101	FlyBaseID:	FBgn0037668	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_068605.1	Gene:	UCP1 / 7350	HGNCID:	12517	Length:	307	Species:	Homo sapiens

Alignment Length:	262	Identity:	50/262 - (19%)
Similarity:	80/262 - (30%)	Gaps:	107/262 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VYVGLLIKTTAQLLSHPMELVRVNMQANVIHHSRLSINHMFRLMARHGLPGFYYGIVAACLRCTV 67
            :..||.....|..:..|.|:|:|.:||.         :|:      ||:...|.|
Human   117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQ---------SHL------HGIKPRYTG---------- 156

  Fly    68 HTMSTYTLFYNLQDNKYVLMLQPYNTSMVLGITGFWGGVLATPFAKLAVIRQA------DLTRGS 126
             |.:.|.:....:                 |:||.|.|  .||....:||...      ||.:.:
Human   157 -TYNAYRIIATTE-----------------GLTGLWKG--TTPNLMRSVIINCTELVTYDLMKEA 201

  Fly   127 YERRNYRNFWRGLKCMYAKGGFTYLFTGWKINSISSTAVAVLYTPISDKVHTVISWFHRLDEPWL 191
            :.:.|.                                       ::|            |.|
Human   202 FVKNNI---------------------------------------LAD------------DVP-- 213

  Fly   192 SDLITMALTGSIITVIMTPVDALATLTLNESSHYGR-TSYPYLYRKIIRKHGYKGFFFGWKPALM 255
            ..|::..:.|...|.:.:|||.:.|..:|  |..|: .|.|....|:....|...||.|..|:.:
Human   214 CHLVSALIAGFCATAMSSPVDVVKTRFIN--SPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFL 276

  Fly   256 AL 257
            .|
Human   277 RL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16736	NP_649873.1	Mito_carr	6..81	CDD:278578	16/74 (22%)
CG16736	NP_649873.1	Mito_carr	187..277	CDD:278578	21/72 (29%)
UCP1	NP_068605.1	Mito_carr	10..104	CDD:278578
		Solcar 1	11..102
		Mito_carr	111..206	CDD:278578	27/133 (20%)
		Solcar 2	111..201		27/128 (21%)
		Solcar 3	210..295		22/85 (26%)
		Mito_carr	215..300	CDD:278578	19/66 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810