Protein Alignment ARSB and Ids

DIOPT Version :10

• Sequence 1: NP_000037.2
• Gene: ARSB / 411
• HGNCID: 714
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_647814.1
• Gene: Ids / 38423
• FlyBaseID: FBgn0035445
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 117/498 - (23%)
• Similarity: 170/498 - (34%)
• Gaps: 167/498 - (33%)

Human    17 RLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRI-RTPHLDALAAGGV 80
            ||||.:::| :||...|||       |.|::|.::.|||. ..:|.:|..: .||:||..|.|..
  Fly     5 RLLLSLMMP-VLLDAAAPP-------RRPNVVMVIFDDLR-PVIGAYGDTLASTPYLDNFARGSH 60

Human    81 LLDNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDE------------KLLPQL 132
            :....|: |.||.|||:.|||||               :|..:.|.:            ..|||.
  Fly    61 IFTRVYSQQSLCAPSRNSLLTGR---------------RPDTLHLYDFYSYWRTFTGNFTTLPQY 110

Human   133 LKEAGYTTHMVGK-WHLGMYRKECLPTRRGFDTY------FGYLLGSEDYYSHERCTLIDALNVT 190
            .||.||.|:..|| :|.|:       :....|.|      ..:...:|.:.:...|.  |...:.
  Fly   111 FKEHGYYTYSCGKVFHPGL-------SSNNTDDYPLSWSAPAFRPRTEQFMNSPVCP--DKEGIL 166

Human   191 R----CALDFR--------DGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
            |    |.::.:        |.|.||...           |.:...:.|..| |.||.:.....|.
  Fly   167 RKNLICPVELQTQPYKTLPDIESVAEAL-----------RFVGSRSRHSQE-PFFLAMGFHKPHI 219

Human   244 PLQVPEEYLKPYDFIQDKN---------------------------------------------- 262
            ..:.|.::|..::..|..|
  Fly   220 NFRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAWNPYTDVRARDDFKHSNISFPYGPISPLQAA 284

Human   263 --RHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPL----RGRKWSL 321
              |..|...||.:|:..|.:...|.    .:.||.:...|:|         |.|    ...|:|.
  Fly   285 QIRQSYYASVSYVDDLFGKLIGGLD----LDETVVVALGDHG---------WSLGEHAEWAKYSN 336

Human   322 WEGGVRGVGFVASPLLKQKGVKNRELIH----ISDWLPTLVKLARGHTNGTKPLDGFDVWK--TI 380
            :|..:|....:.||   |..|...:..|    :.|..||||.||     |...||.....:  |.
  Fly   337 FEVALRVPLIIRSP---QFPVAQTKYYHGITELLDVFPTLVDLA-----GLPKLDKCQSSQELTC 393

Human   381 SEGSPSPRIELLHNI-----DPNFVDSSPCPRNSMAPAKDDSS 418
            .||.     .|.|.:     ....|..|..||..|.|.|..:|
  Fly   394 GEGK-----SLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNS 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARSB	NP_000037.2	4-S	45..488	CDD:293753	106/470 (23%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	106/471 (23%)