DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment St2 and SULT1B1

DIOPT Version :9

Sequence 1:	NP_001287244.1	Gene:	St2 / 41098	FlyBaseID:	FBgn0037665	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	XP_005265733.1	Gene:	SULT1B1 / 27284	HGNCID:	17845	Length:	301	Species:	Homo sapiens

Alignment Length:	315	Identity:	89/315 - (28%)
Similarity:	156/315 - (49%)	Gaps:	49/315 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VEVLPDQFIIPRKYVEL-------------GESIRSLPVYQDDVWMVSYPRTGSTWAQEMVWLLG 78
            :||....:|: ||.::|             .|.|.......||:.:.:||::|:||..|::
Human     4 MEVFSRNYIL-RKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEII---- 63

  Fly    79 HQLDYVAAEQDLRL--------RSPLIELSALFSIDHHETVAQKFGNTVDLVRNLPRPRFARSHL 135
               |.:..:.|:..        :.|::|:          |:.....:.::.:...|.||..::||
Human    64 ---DMILNDGDIEKCKRGFITEKVPMLEM----------TLPGLRTSGIEQLEKNPSPRIVKTHL 115

  Fly   136 PWPLLPEQFETVKPRIVYTARNPKDLCVSYYHYFKLLHGMN---GDFEQFVDLFLEGHTPMGSYW 197
            |..|||:.|.....:::|.|||.||:.||||| |.|::.:.   |.:|::::.||.|....||::
Human   116 PTDLLPKSFWENNCKMIYLARNAKDVSVSYYH-FDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWF 179

  Fly   198 RHVLPFWKRSQDDNVLFIKYEDMVKDLPSVVRRCARFLGVQSLLDVSTLQKLCDHLTFDKMRANK 262
            .||..:||:.::..:||:.||||.::....:::..|||  :..|:...|.::..|.:|:.|:.|.
Human   180 THVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFL--EKNLNDEILDRIIHHTSFEVMKDNP 242

  Fly   263 AVNLEKL----LPESSSKFIRNGKIGDWRNHMGNEMSERFDEWTERHMRGSGLNF 313
            .||...|    :..|.|.|:|.|..|||:|:.....:|:||...|..|..:.|.|
Human   243 LVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQF 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
St2	NP_001287244.1	Sulfotransfer_1	55..310	CDD:279075	79/269 (29%)
SULT1B1	XP_005265733.1	Sulfotransfer_1	43..293	CDD:279075	79/269 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1584
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49491
OrthoDB	1	1.010	-	-		D481448at33208
OrthoFinder	1	1.000	-	-		FOG0000045
OrthoInspector	1	1.000	-	-		mtm8578
orthoMCL	1	0.900	-	-		OOG6_100094
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5451
SonicParanoid	1	1.000	-	-		X38
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760