DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps15 and VPS15

DIOPT Version :9

Sequence 1:	NP_649868.1	Gene:	Vps15 / 41096	FlyBaseID:	FBgn0260935	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_194667.1	Gene:	VPS15 / 829059	AraportID:	AT4G29380	Length:	1494	Species:	Arabidopsis thaliana

Alignment Length:	1584	Identity:	444/1584 - (28%)
Similarity:	704/1584 - (44%)	Gaps:	332/1584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNQLVGIAPSQIYAVEHYFSGQFGS-EIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTL 64
            |||::.  ..:|:.|.|:|......| .:.....:|..||.|..:.|.|||.:||||:.|...::
plant     1 MGNKIA--RTTQVSATEYYLHDLPSSYNLVLKEVLGRGRFLKSIQCKHDEGLVVVKVYFKRGDSI 63

  Fly    65 PLEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKW 129
            .|.:::.||..||.........:..|||..:..|||||::|:|...:|:||:||||||:::||||
plant    64 DLREYERRLVKIKDVFLSLEHPHVWPFQFWQETDKAAYLVRQYFYSNLHDRLSTRPFLSLVEKKW 128

  Fly   130 ITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSRR 194
            :.||:|.|:.|||::.|||||||.||:|:|||||:.|:|||||||||:|.|:|:|:::||||..:
plant   129 LAFQLLLAVKQCHEKDICHGDIKCENVLLTSWNWLYLADFASFKPTYIPYDDPSDFSFFFDTRGQ 193

  Fly   195 RTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPSYAGNTLLPAMDIFSAGCALLELWTEG 259
            |.||:|||||.      :.||.        ..:.:.||      |.|:||||:.||.:.||:.||
plant   194 RLCYLAPERFY------EHGGE--------TQVAQDAP------LKPSMDIFAVGCVIAELFLEG 238

  Fly   260 TAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYLDQERGQLFPEY 324
            ...|||:||||||||:.| ..:||..|.:..:|.::..||.:....|.||||||....|.:||.|
plant   239 QPLFELAQLLAYRRGQHD-PSQHLEKIPDPGIRKMILHMIQLEPEARLSAEDYLQNYVGVVFPNY 302

  Fly   325 FYSFLQSYL----------------------------------------------------QMFS 337
            |..||.:..                                                    :.|:
plant   303 FSPFLHTLYCCWNPLPSDMRVATCQGIFQEILKKMMENKSGDEIGVDSPVTSNPMNASTVQETFA 367

  Fly   338 STPIMSPDDKIQ---------------CLHKDIGHCIKVLTQAQDLTPEEEEKEEKKDPTLCARL 387
            :..:.|..|.|:               .|.|:....:|.:|. .||.......:.:.|......|
plant   368 NHKLNSSKDLIRNTVNSKDEIFYSISDALKKNRHPFLKKITM-DDLGTLMSLYDSRSDTYGTPFL 431

  Fly   388 PPEH----DGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILHLAQKS 448
            |.|.    :|::||.:::.||||.:|..:.:..|:.||:..|.|...:..|.|:|||::.|....
plant   432 PVEGNMRCEGMVLIASMLCSCIRNIKLPHLRREAILLLRSCSLYIDDDDRLQRVLPYVVALLSDP 496

  Fly   449 PAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAALAKSA 513
            .|.|:..|:|||...|.:|:|.|.|||.:|||||.|.::.|..:|.. .||:.:|.|||.||.:|
plant   497 TAIVRCAAMETLCDILPLVRDFPPSDAKIFPEYIFPMLSMLPEDTEE-SVRICYASNIAKLALTA 560

  Fly   514 VYFLEET----------QRNAPNDMPTPRYE-----------AELNALHDIVRQAVLSLLTDSQ- 556
            ..||..:          :.|:.....||..|           |:|..|...:.:.|..|:...:
plant   561 YGFLIHSFQLSDVGVLNELNSQQISTTPASETPSHLQKANGNAQLQQLRKTIAEVVQELVMGPKQ 625

  Fly   557 -PVVKQTLMESGICDLCAFFGKEKANDVILSHIMTFLNDEDKNLRGAFYDNIAGVAGYVGWQA-S 619
             |.|::.|::. |.:||.|||:.::||.:|..:..||||.|:.||..|::.|..|..:||.:: .
plant   626 TPNVRRALLQD-IGELCFFFGQRQSNDFLLPILPAFLNDRDEQLRSVFFEKIVYVCFFVGQRSVE 689

  Fly   620 DILVPLLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGM 684
            :.|:|.:.|..:|:.|.||..|:..::.|.:...::|.|:.::::.....||:|:.|||..:...
plant   690 EYLLPYIDQALSDQTEAVIVNALECLSTLCKSSFLRKRALLQMIECVYPLLCYPSQWVRRAVVTF 754

  Fly   685 IATTARNLSAIDVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQI--------------- 734
            ||.::..|.|:|....|.|.|.::|......:.....||.|:.|||.|::
plant   755 IAASSECLGAVDSYAFIAPVIRSYLSRLPASIASEEGLLSCLKPPVTREVVYRIFEKTRNPEFMA 819

  Fly   735 ---------------FDSVLRFQDIHHFIRALEARS----------RVRSQTRQGALP-QYEEMG 773
                           ::||..|......:.::|.|:          :::|.::|..:. :|.|..
plant   820 KQRKMWYSSSPQSKDWESVDLFDKDAGELNSVECRAEQKQSVEGKKQIKSASKQPEVQGKYAEKD 884

  Fly   774 QTLRNLFRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDDTASGNGRIVVSRKQVACHEYPL 838
            ..||                   :..||         ..:..:|......:...:.|.:....|.
plant   885 AKLR-------------------IPRNP---------RPNASNTVELRDPVYPEKLQFSGFMAPY 921

  Fly   839 ADKAS------KMPL-----DNRSSEGPTLASPASDAAITPLGAGGLA-----GSPASGAVVLGV 887
            ...|:      .:||     |.|::..|.:||.:| ..:..||.|.|:     ....|..:...|
plant   922 VSGANSFIEPENIPLYSFSMDKRAATNPPVASESS-LQMNSLGMGSLSVPWMDSMSKSFNLASSV 985

  Fly   888 PT-ATVSAATSLGEYTMPERNCWLERSSECRKDLESLTAKIKSRYNVLAISQRC----------- 940
            |. ..:|.:..:|  |.|::...:....|.|:: :.:::.| |::..|.:|...
plant   986 PVPKLISGSFHVG--TNPKQFYRVVHEPESREN-DQISSAI-SKFQDLGVSSSSKSASVTSEDAS 1046

  Fly   941 ---------SYDKLVTPYPPGWRMTGTLVAHLHEHSESVIKLASLRPHGSLFASGSIDGTVRLWD 996
                     |..:...| ..||:..|.|||||.||..:|..:|:...| |.|.|.|.|.||::||
plant  1047 SPADLVGEPSLSRTSVP-DSGWKPRGVLVAHLQEHRSAVNDIATSSDH-SFFVSASDDSTVKVWD 1109

  Fly   997 CSKLNGNQGVNKSRQVYSANTPIYALAACD----SGQSLAVGGKDGSMLMMRIDRNS-------A 1050
            ..||..:... :||..|....   :...|.    :...:.||..||.:.|..||..|       .
plant  1110 SRKLEKDISF-RSRLTYHLEG---SRGMCTTMLRNSTQVVVGASDGVIHMFSIDHISRGLGNVVE 1170

  Fly  1051 KMTLQQALNQNDHKDGPVVDMHAY--DQATQSVIVYATLYGGIVAWDTRMQHSAWRLQNELRHGV 1113
            |.:....:.:.|.|:|.:|.:..|  |..:..:::|:|...||..||||....||.|:.....|.
plant  1171 KYSGIVDIKKKDVKEGALVSLLNYTADSLSGPMVMYSTQNCGIHLWDTRSDLDAWTLKANPEEGY 1235

  Fly  1114 ITTICADPTGSWLATGTSGGKHICWDLRFRLPIAEIKHPADSWIRKVACHPTEPSYLISASQSN- 1177
            ::::...|.|:|..:|:|.|....||||||:|:...::|....|.|:......||..:|.:...
plant  1236 VSSLVTSPCGNWFVSGSSRGVLTLWDLRFRVPVNSWQYPIICPIEKMCLCFLPPSVSVSTTMKPL 1300

  Fly  1178 -------NEVSVWNIETGQRQTVL---------------WASP-------------------VAA 1201
                   ||||:||.|.|....||               |..|                   :..
plant  1301 IYVAAGCNEVSLWNAEGGSCHQVLRVANYENETDVSEFQWKLPSNKVNPKPNHRQNMSSKYRIEE 1365

  Fly  1202 LSSASPSDPATTCGILSGVVDGSPFILTGSSDQRIRYWDITNPKNS------SLKVPAANDNLAD 1260
            |:...|..|    ||.|.:......:|||.:|.:||.||.::|:.|      ||| ...||:..:
plant  1366 LNEPPPRLP----GIRSLLPLPGGDLLTGGTDLKIRRWDYSSPERSYCICGPSLK-GVGNDDFYE 1425

  Fly  1261 VAFNYGARLID-------GSQVIEEQIISMASTGDSQQLRSSTEENPRSGPDMPTASHHDAITDL 1318
            :..|.|.:.:.       .:::..:.:::.|:|..:                   ..|.|::..|
plant  1426 LKTNTGVQFVQETKRRPLATKLTAKAVLAAAATDTA-------------------GCHRDSVQSL 1471

  Fly  1319 LMCKDKGQIYIASASRNGVIKLWK 1342
            ...| ..|..:.|:||:|.||:||
plant  1472 ASVK-LNQRLLISSSRDGAIKVWK 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps15	NP_649868.1	STKc_Vps15	27..325	CDD:270882	133/297 (45%)
		S_TKc	41..311	CDD:214567	123/269 (46%)
		HEAT repeat	436..469	CDD:293787	13/32 (41%)
		HEAT repeat	483..508	CDD:293787	8/24 (33%)
		HEAT repeat	543..573	CDD:293787	7/31 (23%)
		HEAT repeat	583..613	CDD:293787	11/29 (38%)
		HEAT repeat	621..650	CDD:293787	9/28 (32%)
		WD40	953..1240	CDD:295369	97/341 (28%)
		WD40	<958..1342	CDD:225201	119/451 (26%)
		WD40 repeat	1020..1063	CDD:293791	10/53 (19%)
		WD40 repeat	1068..1107	CDD:293791	14/40 (35%)
		WD40 repeat	1115..1150	CDD:293791	13/34 (38%)
		WD40 repeat	1157..1194	CDD:293791	13/44 (30%)
		WD40 repeat	1199..1241	CDD:293791	13/41 (32%)
		WD40 repeat	1259..1309	CDD:293791	4/56 (7%)
VPS15	NP_194667.1	STKc_Vps15	16..303	CDD:270882	135/307 (44%)
		HEAT repeat	448..474	CDD:293787	8/25 (32%)
		HEAT repeat	484..511	CDD:293787	11/26 (42%)
		HEAT repeat	652..682	CDD:293787	11/29 (38%)
		HEAT repeat	691..717	CDD:293787	8/25 (32%)
		HEAT repeat	726..757	CDD:293787	9/30 (30%)
		WD40	1071..1325	CDD:330360	81/258 (31%)
		WD40 repeat	1085..1129	CDD:293791	16/45 (36%)
		WD40 repeat	1134..1193	CDD:293791	14/58 (24%)
		WD40 repeat	1194..1230	CDD:293791	13/35 (37%)
		WD40 repeat	1236..1272	CDD:293791	13/35 (37%)
		WD40 repeat	1279..1315	CDD:293791	10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I891
eggNOG	1	0.900	-	-		E1_KOG1240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24678
Inparanoid	1	1.050	602	1.000	Inparanoid score	I219
OMA	1	1.010	-	-		QHG58143
OrthoDB	1	1.010	-	-		D1312453at2759
OrthoFinder	1	1.000	-	-		FOG0004354
OrthoInspector	1	1.000	-	-		oto3022
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17583
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	12.030