DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps15 and pik3r4

DIOPT Version :9

Sequence 1:	NP_649868.1	Gene:	Vps15 / 41096	FlyBaseID:	FBgn0260935	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001107701.1	Gene:	pik3r4 / 779618	XenbaseID:	XB-GENE-978522	Length:	1361	Species:	Xenopus tropicalis

Alignment Length:	1436	Identity:	583/1436 - (40%)
Similarity:	842/1436 - (58%)	Gaps:	169/1436 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLP 65
            |||||.|||||||.:|:.|||..  .|..:..::|||||||||:||..||.:|||||...||:||
Frog     1 MGNQLAGIAPSQILSVDSYFSDI--HEFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPSLP 63

  Fly    66 LEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKWI 130
            |.::|:.||.:|  :.|.::.||||||:..|.:|||.:.|::|:.:||||:||||||..:||:||
Frog    64 LTNYKQELEELK--IRLCSSQNCLPFQKFTLNEKAALLFRQFVRDNLYDRISTRPFLNNIEKRWI 126

  Fly   131 TFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSRRR 195
            .||||.|::|.||..:.|||||.||:::|||||:||:|||||||||||||||||:.|||||||||
Frog   127 AFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRR 191

  Fly   196 TCYIAPERFV------KTLASDDDGGNGNMSVIHTDSIIRLAPSYAGNTLLPAMDIFSAGCALLE 254
            ||||||||||      ..|.|..|.....:.:.:.:...|       ..|..|||||||||.:.|
Frog   192 TCYIAPERFVDGSTFSTELESIKDPSTPLVDLTNNNQRTR-------GDLKRAMDIFSAGCVIAE 249

  Fly   255 LWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYLDQERGQ 319
            |:|||...|:|||||||::|:.. .::.:..||:..:|.|:..||......|.:|||||.|:||.
Frog   250 LFTEGVPLFDLSQLLAYKKGQFS-PDQVMGKIEDSSIRQLVIQMICREPEKRLAAEDYLKQQRGN 313

  Fly   320 LFPEYFYSFLQSYLQMFSSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEEKKDPTLC 384
            .|||.||:|||.|:..|:.....|.|::|..:.||:.:.|..|  ..|...|:.|.|.|:
Frog   314 AFPEIFYTFLQPYMAQFAKETFHSADERILVIRKDLDNIIHNL--CGDDQSEKVEGEIKE----- 371

  Fly   385 ARLPPEHDGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILHLAQKSP 449
                   :||:::::|:|||::.||..::|:|||||:..|:.....|.:||||.||:||....|.
Frog   372 -------NGLLILVSVITSCLQTLKYCDSKLAALELILHLAPRINVEILLDRITPYLLHFCNDSV 429

  Fly   450 AKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAALAKSAV 514
            .:|:.:|:.|||..|.:||::||:|.|::||||||.|..||.: .|.|||:|:|.|||.||::|:
Frog   430 PRVKAEAVRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQD-EATIVRLAYAENIALLAETAL 493

  Fly   515 YFLEETQ---RNAPND----------MPTPRYEAELNALHDIVRQAVLSLLTDSQPVVKQTLMES 566
            .|||..|   .|..||          .|:..|:.||.|||::|:|.|::||:|.:.:|||||||:
Frog   494 RFLELVQLKNLNMENDPSSEELDEVSHPSESYDTELQALHEMVQQKVVTLLSDPENIVKQTLMEN 558

  Fly   567 GICDLCAFFGKEKANDVILSHIMTFLNDE-DKNLRGAFYDNIAGVAGYVGWQASDILVPLLQQGF 630
            ||..||.|||::|||||:|||::|||||: |.:|||||:|:|.|||.|||||:|.||.||||||.
Frog   559 GITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGL 623

  Fly   631 TDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTARNLSAI 695
            :|.|||||.||:.|:|.:.:||.::||.:.|...:.|.:|||||||:|:...|.|.|.|:.|:..
Frog   624 SDVEEFVIFKALNALTCMCQLGLLQKPHIYEFACDIAPFLCHPNLWIRYGAVGFITTVAQQLNIA 688

  Fly   696 DVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEARSRVRSQ 760
            ||.||:||.:..|:..|:||::|..:||..:..||.|.|||..||.:||....|.|    .:|.:
Frog   689 DVYCKLMPYLHPFITQPIIQIDKEIVLLSVLKEPVSRSIFDYALRSKDIASLFRHL----HMRQK 749

  Fly   761 TRQGALPQY---EEMGQTLRNLFRRLSSEGLTDLIEMQLLAMNPFLI------------------ 804
            .|.|:||:.   |:  ..:..|.::|.|:|:|:..|.:|||:..:::
Frog   750 KRNGSLPECPPPED--PAITQLLKKLLSQGMTEDEEDKLLALKDYMLKSNKAKANVADQSHIHES 812

  Fly   805 SMKH-----------------KALQDLDDTASGNGRIVVSRKQVACHEYPL-------------- 838
            |:|.                 |..||.||..        :||.|. .||.:
Frog   813 SLKGVIDLSALGLSGRQADLIKTKQDTDDKR--------ARKHVK-QEYNVNEEWKSMFGAMEPV 868

  Fly   839 ----------ADKASKMPLDNRSSEGPTLASPASDAAITPLGAGGLAGSPASGAVVLGVPTATVS 893
                      ||:.:..|:  ||.....:.:|.|.:..|..|.|.....|            |:.
Frog   869 NVNQTVVRTAADQEATKPV--RSESAAAVCAPLSSSPQTSEGTGMQPRRP------------TMQ 919

  Fly   894 AATSLGEYTMPERNCWLERSSECRKDLESLTAKIKSRYNVLAISQRC--SYDKLVTPYPPGWRMT 956
            ..||:   ::|  :.:..|.:.|:.:|:.|..:.:.:.|...|::..  |.:....|.|.||...
Frog   920 IYTSI---SLP--STFQIRMTTCKSELQQLIQQKREQCNAERIAKHMMESAEWESKPPPTGWHPK 979

  Fly   957 GTLVAHLHEHSESVIKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYS-ANTPIY 1020
            |.||||||||...|.::.....| |:||:.|.||||::|:..|:.|.....:|...|| ....:.
Frog   980 GLLVAHLHEHKGPVNRIRVSDEH-SIFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGHVK 1043

  Fly  1021 ALAACDSGQSLAVGGKDGSMLMMRIDRN----SAKMTLQQALNQNDHKDGPVVDMHAYDQATQSV 1081
            .|..|.....|||...:|::.::.|:.:    |.|:...|:...:..:||.|||||.::..:|||
Frog  1044 TLTFCQGSHYLAVASDNGNIQLLGIEASKPPKSPKINPLQSRTLDLQEDGCVVDMHQFNAGSQSV 1108

  Fly  1082 IVYATLYGGIVAWDTRMQHSAWRLQNELRHGVITTICADPTGSWLATGTSGGKHICWDLRFRLPI 1146
            :.|||:.|.:|.||.|...:||.|:::||.|:||:...|....||..|||.|...|||:||:|||
Frog  1109 LAYATVNGSLVGWDLRCPSNAWTLKHDLRLGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPI 1173

  Fly  1147 AEIKHPADSWIRKVACHPTE-----PSYLISASQSNNEVSVWNIETGQRQTVLWASPVAALSSAS 1206
            :...|||.:.||::..||..     .|::|:|.|.|||||:|::|||.|:..||||....||...
Frog  1174 SSHTHPARARIRRLLMHPLSMHTMYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASNSPPLSEMQ 1238

  Fly  1207 PSDPATTCGILSGVVDGSPFILTGSSDQRIRYWDITNPKNSSLKVPAANDNLADVAFNYGARLID 1271
            || |.:..||.....||:|.:||..||.:||:|::..||.|.: :..:.:||..|  :|.:::|:
Frog  1239 PS-PHSVHGIYCSPADGNPILLTAGSDMKIRFWNLACPKRSYI-IAGSTNNLPPV--SYFSKIIE 1299

  Fly  1272 GSQVIEEQIISMASTGDSQQLRSSTEENPRSGPDMPTASHHDAITDLLMCKDKGQIYIASASRNG 1336
            |::|::| |.:..:.|.|       ::.||.||:...|.|||.|||::..:.. |.:|.:|||:|
Frog  1300 GTEVVQE-IQNKHTMGPS-------DDTPRKGPESLPAGHHDIITDIVTFQTT-QGFIVTASRDG 1355

  Fly  1337 VIKLWK 1342
            ::|:||
Frog  1356 IVKVWK 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps15	NP_649868.1	STKc_Vps15	27..325	CDD:270882	159/303 (52%)
		S_TKc	41..311	CDD:214567	142/275 (52%)
		HEAT repeat	436..469	CDD:293787	14/32 (44%)
		HEAT repeat	483..508	CDD:293787	13/24 (54%)
		HEAT repeat	543..573	CDD:293787	16/29 (55%)
		HEAT repeat	583..613	CDD:293787	20/30 (67%)
		HEAT repeat	621..650	CDD:293787	18/28 (64%)
		WD40	953..1240	CDD:295369	118/296 (40%)
		WD40	<958..1342	CDD:225201	149/393 (38%)
		WD40 repeat	1020..1063	CDD:293791	10/46 (22%)
		WD40 repeat	1068..1107	CDD:293791	19/38 (50%)
		WD40 repeat	1115..1150	CDD:293791	16/34 (47%)
		WD40 repeat	1157..1194	CDD:293791	18/41 (44%)
		WD40 repeat	1199..1241	CDD:293791	17/41 (41%)
		WD40 repeat	1259..1309	CDD:293791	13/49 (27%)
pik3r4	NP_001107701.1	STKc_Vps15	25..319	CDD:270882	159/303 (52%)
		S_TKc	26..308	CDD:214567	151/291 (52%)
		HEAT repeat	378..403	CDD:293787	12/24 (50%)
		HEAT repeat	417..445	CDD:293787	11/27 (41%)
		HEAT repeat	461..491	CDD:293787	18/30 (60%)
		HEAT repeat	538..565	CDD:293787	15/26 (58%)
		HEAT repeat	575..606	CDD:293787	20/30 (67%)
		HEAT repeat	613..640	CDD:293787	17/26 (65%)
		HEAT repeat	649..681	CDD:293787	14/31 (45%)
		WD40	982..1271	CDD:295369	116/290 (40%)
		WD40	988..1361	CDD:225201	143/386 (37%)
		WD40 repeat	994..1037	CDD:293791	14/43 (33%)
		WD40 repeat	1042..1088	CDD:293791	10/45 (22%)
		WD40 repeat	1096..1137	CDD:293791	18/40 (45%)
		WD40 repeat	1141..1188	CDD:293791	22/46 (48%)
		WD40 repeat	1196..1232	CDD:293791	18/35 (51%)
		WD40 repeat	1244..1270	CDD:293791	11/25 (44%)
		WD40	<1330..1361	CDD:197651	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	468	1.000	Domainoid score	I456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24678
Inparanoid	1	1.050	976	1.000	Inparanoid score	I315
OMA	1	1.010	-	-		QHG58143
OrthoDB	1	1.010	-	-		D1312453at2759
OrthoFinder	1	1.000	-	-		FOG0004354
OrthoInspector	1	1.000	-	-		oto103184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R969
SonicParanoid	1	1.000	-	-		X3072
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010