DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps15 and Pik3r4

DIOPT Version :9

Sequence 1:	NP_649868.1	Gene:	Vps15 / 41096	FlyBaseID:	FBgn0260935	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_006243862.1	Gene:	Pik3r4 / 363131	RGDID:	1311809	Length:	1358	Species:	Rattus norvegicus

Alignment Length:	1422	Identity:	587/1422 - (41%)
Similarity:	833/1422 - (58%)	Gaps:	144/1422 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLP 65
            |||||.|||||||.:||.|||.....|  :..::|||||||||:||..||.:|||||...|||||
  Rat     1 MGNQLAGIAPSQILSVESYFSDIHDFE--YDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLP 63

  Fly    66 LEDHKERLEGIKKTLSLANAVNCLPFQRV--ELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKK 128
            |..:|:.||.:|  :.|.:|.||||||:.  :..:|||.:.|:||:.:||||:||||||..:||:
  Rat    64 LTSYKQELEELK--IRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKR 126

  Fly   129 WITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSR 193
            ||.||||.|::|.||..:.|||||.||:::|||||:||:|||||||||||||||||:.|||||||
  Rat   127 WIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSR 191

  Fly   194 RRTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPS----------YAGNTLLPAMDIFSA 248
            ||||||||||||       |||     :..|:......||          .....|..|||||||
  Rat   192 RRTCYIAPERFV-------DGG-----MFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSA 244

  Fly   249 GCALLELWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYL 313
            ||.:.||:|||...|:||||||||.| ....|:.|..||:..:|.|:..||......|..|:|||
  Rat   245 GCVIAELFTEGVPLFDLSQLLAYRNG-HFFPEQVLNKIEDRSIRELVTQMIQREPGQRLEADDYL 308

  Fly   314 DQERGQLFPEYFYSFLQSYLQMFSSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEEK 378
            .|:||..|||.||:|||.|:..|:....:|.|::|..:.||:|:.|..|. ..|| ||:.|.|.|
  Rat   309 KQQRGNAFPEVFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLC-GHDL-PEKAEGESK 371

  Fly   379 KDPTLCARLPPEHDGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILH 443
            .            .||:::::|:|||::.||..::|:|||||:..|:...:.|.:||||.||:||
  Rat   372 A------------SGLVVLVSVITSCLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLH 424

  Fly   444 LAQKSPAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAA 508
            .:..|..:|:.:|:.|||..|.:|:::||:|.|::||||||.|..||.: .|.|||:|:|.|||.
  Rat   425 FSNNSVPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIAHLAQD-DATIVRLAYAENIAL 488

  Fly   509 LAKSAVYFLEETQ------RNAPND-------MPTPRYEAELNALHDIVRQAVLSLLTDSQPVVK 560
            ||::|:.|||..|      .|.|:.       .|...|:.||.|||::|:|.|::||:|.:.:||
  Rat   489 LAETALRFLELVQLKTLNMENEPDSEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVK 553

  Fly   561 QTLMESGICDLCAFFGKEKANDVILSHIMTFLNDE-DKNLRGAFYDNIAGVAGYVGWQASDILVP 624
            |||||:||..||.|||::|||||:|||::|||||: |.:|||||:|:|.|||.|||||:|.||.|
  Rat   554 QTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKP 618

  Fly   625 LLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTA 689
            |||||.:|.|||||.||:.|:|.:.:||.::||.|.|...:.|.:|||||||:|:...|.|...|
  Rat   619 LLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVA 683

  Fly   690 RNLSAIDVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEAR 754
            ..:|..||.||:||.:..::..|:||:|:..:||..:..||.|.|||..||.:||....|.|
  Rat   684 HQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHL--- 745

  Fly   755 SRVRSQTRQGAL---PQYEEMGQTLRNLFRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDD 816
             .:|.:.|.|:|   |..|:  ..:..|.::|.|:|:|:..|.:|||:..|::.........:|.
  Rat   746 -HMRQKKRNGSLLDCPPPED--PAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQ 807

  Fly   817 T----ASGNGRIVVSRKQVACHEYPLADKASKMPLDNR--------------------SSEGPTL 857
            :    :|..|.|.::...:...:..|. |..:.|.:.|                    |.|.|.:
  Rat   808 SHLHDSSQKGVIDLAALGITGRQVDLV-KTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNI 871

  Fly   858 --ASP-ASDAAITPLGAGGLAGSPASGAVVLGV--------------PTATVSAATSL-GEYTMP 904
              |.| .||..:.|.|....:.|.|...|.|..              |...|.::|.| ..|.:
  Rat   872 PQALPKTSDHEVVPTGKSPRSESSAGVCVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQI- 935

  Fly   905 ERNCWLERSSECRKDLESLTAKIKSRYNVLAIS----QRCSYDKLVTPYPPGWRMTGTLVAHLHE 965
                   |.:.|:.:|:.|..:.:.:.|...|:    :...::.  .|.|||||..|.|||||||
  Rat   936 -------RITTCKTELQQLIQQKREQCNAERIAKQMMENAEWES--KPPPPGWRPKGLLVAHLHE 991

  Fly   966 HSESVIKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYS-ANTPIYALAACDSGQ 1029
            |..:|.::.....| .|||:.|.||||::|:..|:.|.....:|...|| ....:..|..|....
  Rat   992 HKSAVNRIRVSDEH-LLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSH 1055

  Fly  1030 SLAVGGKDGSMLMMRIDRN----SAKMTLQQALNQNDHKDGPVVDMHAYDQATQSVIVYATLYGG 1090
            .||:...:|::.::.|:.:    |.|:...|:...:..:||.|||||.::...|||:.|||:.|.
  Rat  1056 YLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGS 1120

  Fly  1091 IVAWDTRMQHSAWRLQNELRHGVITTICADPTGSWLATGTSGGKHICWDLRFRLPIAEIKHPADS 1155
            :|.||.|...:||.|:::|:.|:||:...|....||..|||.|...|||:||:|||:...||:.:
  Rat  1121 LVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRA 1185

  Fly  1156 WIRKVACHPTEPSYLISASQSNNEVSVWNIETGQRQTVLWASPVAALSSASPSDPATTCGILSGV 1220
            .||:::.||...|::|:|.|.|||||:|::|||.|:..||||....||...|| |.:..||....
  Rat  1186 RIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRLTLWASSAPPLSELQPS-PHSVHGIYCSP 1249

  Fly  1221 VDGSPFILTGSSDQRIRYWDITNPKNSSLKVPAANDNLADVAFNYGARLIDGSQVIEEQIISMAS 1285
            .||:|.:||..||.:||:||:.:|:.|  .|.|.:.....|  :|..::|:|::|::| |.:...
  Rat  1250 ADGNPILLTAGSDMKIRFWDLVSPERS--YVVAGSTGSPSV--SYYKKIIEGTEVVQE-IQNKQK 1309

  Fly  1286 TGDSQQLRSSTEENPRSGPDMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK 1342
            .|.|       ::.||.||:.....|||.|||:...:.. |.:|.:|||:|::|:||
  Rat  1310 VGPS-------DDTPRRGPESLPVGHHDIITDIATFQTT-QGFIVTASRDGIVKVWK 1358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps15	NP_649868.1	STKc_Vps15	27..325	CDD:270882	165/309 (53%)
		S_TKc	41..311	CDD:214567	149/281 (53%)
		HEAT repeat	436..469	CDD:293787	14/32 (44%)
		HEAT repeat	483..508	CDD:293787	13/24 (54%)
		HEAT repeat	543..573	CDD:293787	16/29 (55%)
		HEAT repeat	583..613	CDD:293787	20/30 (67%)
		HEAT repeat	621..650	CDD:293787	18/28 (64%)
		WD40	953..1240	CDD:295369	116/291 (40%)
		WD40	<958..1342	CDD:225201	145/388 (37%)
		WD40 repeat	1020..1063	CDD:293791	9/46 (20%)
		WD40 repeat	1068..1107	CDD:293791	19/38 (50%)
		WD40 repeat	1115..1150	CDD:293791	16/34 (47%)
		WD40 repeat	1157..1194	CDD:293791	18/36 (50%)
		WD40 repeat	1199..1241	CDD:293791	17/41 (41%)
		WD40 repeat	1259..1309	CDD:293791	13/49 (27%)
Pik3r4	XP_006243862.1	STKc_Vps15	25..320	CDD:270882	165/311 (53%)
		Pkinase	26..309	CDD:278497	158/299 (53%)
		DRIM	<352..>449	CDD:284870	40/110 (36%)
		HEAT repeat	379..404	CDD:293787	12/24 (50%)
		HEAT repeat	418..446	CDD:293787	11/27 (41%)
		HEAT repeat	462..492	CDD:293787	18/30 (60%)
		HEAT repeat	539..566	CDD:293787	15/26 (58%)
		HEAT repeat	576..607	CDD:293787	20/30 (67%)
		HEAT repeat	614..641	CDD:293787	17/26 (65%)
		HEAT repeat	652..682	CDD:293787	13/29 (45%)
		HEAT repeat	694..716	CDD:293787	7/21 (33%)
		WD40	985..1269	CDD:295369	113/285 (40%)
		WD40	991..1358	CDD:225201	139/381 (36%)
		WD40 repeat	997..1040	CDD:293791	14/43 (33%)
		WD40 repeat	1045..1091	CDD:293791	9/45 (20%)
		WD40 repeat	1099..1136	CDD:293791	17/36 (47%)
		WD40 repeat	1144..1179	CDD:293791	17/34 (50%)
		WD40 repeat	1187..1236	CDD:293791	24/48 (50%)
		WD40 repeat	1242..1268	CDD:293791	11/25 (44%)
		WD40	<1327..1358	CDD:197651	13/31 (42%)
		WD40 repeat	1332..1357	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349608
Domainoid	1	1.000	416	1.000	Domainoid score	I636
eggNOG	1	0.900	-	-		E1_KOG1240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24678
Inparanoid	1	1.050	988	1.000	Inparanoid score	I292
OMA	1	1.010	-	-		QHG58143
OrthoDB	1	1.010	-	-		D1312453at2759
OrthoFinder	1	1.000	-	-		FOG0004354
OrthoInspector	1	1.000	-	-		oto96476
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17583
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3072
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870