DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vps15 and Pik3r4

DIOPT Version :10

Sequence 1:NP_649868.1 Gene:Vps15 / 41096 FlyBaseID:FBgn0260935 Length:1342 Species:Drosophila melanogaster
Sequence 2:NP_001388143.1 Gene:Pik3r4 / 363131 RGDID:1311809 Length:1358 Species:Rattus norvegicus


Alignment Length:1422 Identity:587/1422 - (41%)
Similarity:833/1422 - (58%) Gaps:144/1422 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGNQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLP 65
            |||||.|||||||.:||.|||.....|  :..::|||||||||:||..||.:|||||...|||||
  Rat     1 MGNQLAGIAPSQILSVESYFSDIHDFE--YDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLP 63

  Fly    66 LEDHKERLEGIKKTLSLANAVNCLPFQRV--ELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKK 128
            |..:|:.||.:|  :.|.:|.||||||:.  :..:|||.:.|:||:.:||||:||||||..:||:
  Rat    64 LTSYKQELEELK--IRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKR 126

  Fly   129 WITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSR 193
            ||.||||.|::|.||..:.|||||.||:::|||||:||:|||||||||||||||||:.|||||||
  Rat   127 WIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSR 191

  Fly   194 RRTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPS----------YAGNTLLPAMDIFSA 248
            ||||||||||||       |||     :..|:......||          .....|..|||||||
  Rat   192 RRTCYIAPERFV-------DGG-----MFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSA 244

  Fly   249 GCALLELWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYL 313
            ||.:.||:|||...|:||||||||.| ....|:.|..||:..:|.|:..||......|..|:|||
  Rat   245 GCVIAELFTEGVPLFDLSQLLAYRNG-HFFPEQVLNKIEDRSIRELVTQMIQREPGQRLEADDYL 308

  Fly   314 DQERGQLFPEYFYSFLQSYLQMFSSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEEK 378
            .|:||..|||.||:|||.|:..|:....:|.|::|..:.||:|:.|..|. ..|| ||:.|.|.|
  Rat   309 KQQRGNAFPEVFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLC-GHDL-PEKAEGESK 371

  Fly   379 KDPTLCARLPPEHDGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILH 443
            .            .||:::::|:|||::.||..::|:|||||:..|:...:.|.:||||.||:||
  Rat   372 A------------SGLVVLVSVITSCLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLH 424

  Fly   444 LAQKSPAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAA 508
            .:..|..:|:.:|:.|||..|.:|:::||:|.|::||||||.|..||.: .|.|||:|:|.|||.
  Rat   425 FSNNSVPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIAHLAQD-DATIVRLAYAENIAL 488

  Fly   509 LAKSAVYFLEETQ------RNAPND-------MPTPRYEAELNALHDIVRQAVLSLLTDSQPVVK 560
            ||::|:.|||..|      .|.|:.       .|...|:.||.|||::|:|.|::||:|.:.:||
  Rat   489 LAETALRFLELVQLKTLNMENEPDSEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVK 553

  Fly   561 QTLMESGICDLCAFFGKEKANDVILSHIMTFLNDE-DKNLRGAFYDNIAGVAGYVGWQASDILVP 624
            |||||:||..||.|||::|||||:|||::|||||: |.:|||||:|:|.|||.|||||:|.||.|
  Rat   554 QTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKP 618

  Fly   625 LLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTA 689
            |||||.:|.|||||.||:.|:|.:.:||.::||.|.|...:.|.:|||||||:|:...|.|...|
  Rat   619 LLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVA 683

  Fly   690 RNLSAIDVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEAR 754
            ..:|..||.||:||.:..::..|:||:|:..:||..:..||.|.|||..||.:||....|.|   
  Rat   684 HQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHL--- 745

  Fly   755 SRVRSQTRQGAL---PQYEEMGQTLRNLFRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDD 816
             .:|.:.|.|:|   |..|:  ..:..|.::|.|:|:|:..|.:|||:..|::.........:|.
  Rat   746 -HMRQKKRNGSLLDCPPPED--PAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQ 807

  Fly   817 T----ASGNGRIVVSRKQVACHEYPLADKASKMPLDNR--------------------SSEGPTL 857
            :    :|..|.|.::...:...:..|. |..:.|.:.|                    |.|.|.:
  Rat   808 SHLHDSSQKGVIDLAALGITGRQVDLV-KTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNI 871

  Fly   858 --ASP-ASDAAITPLGAGGLAGSPASGAVVLGV--------------PTATVSAATSL-GEYTMP 904
              |.| .||..:.|.|....:.|.|...|.|..              |...|.::|.| ..|.: 
  Rat   872 PQALPKTSDHEVVPTGKSPRSESSAGVCVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQI- 935

  Fly   905 ERNCWLERSSECRKDLESLTAKIKSRYNVLAIS----QRCSYDKLVTPYPPGWRMTGTLVAHLHE 965
                   |.:.|:.:|:.|..:.:.:.|...|:    :...::.  .|.|||||..|.|||||||
  Rat   936 -------RITTCKTELQQLIQQKREQCNAERIAKQMMENAEWES--KPPPPGWRPKGLLVAHLHE 991

  Fly   966 HSESVIKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYS-ANTPIYALAACDSGQ 1029
            |..:|.::.....| .|||:.|.||||::|:..|:.|.....:|...|| ....:..|..|....
  Rat   992 HKSAVNRIRVSDEH-LLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSH 1055

  Fly  1030 SLAVGGKDGSMLMMRIDRN----SAKMTLQQALNQNDHKDGPVVDMHAYDQATQSVIVYATLYGG 1090
            .||:...:|::.::.|:.:    |.|:...|:...:..:||.|||||.::...|||:.|||:.|.
  Rat  1056 YLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGS 1120

  Fly  1091 IVAWDTRMQHSAWRLQNELRHGVITTICADPTGSWLATGTSGGKHICWDLRFRLPIAEIKHPADS 1155
            :|.||.|...:||.|:::|:.|:||:...|....||..|||.|...|||:||:|||:...||:.:
  Rat  1121 LVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRA 1185

  Fly  1156 WIRKVACHPTEPSYLISASQSNNEVSVWNIETGQRQTVLWASPVAALSSASPSDPATTCGILSGV 1220
            .||:::.||...|::|:|.|.|||||:|::|||.|:..||||....||...|| |.:..||....
  Rat  1186 RIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRLTLWASSAPPLSELQPS-PHSVHGIYCSP 1249

  Fly  1221 VDGSPFILTGSSDQRIRYWDITNPKNSSLKVPAANDNLADVAFNYGARLIDGSQVIEEQIISMAS 1285
            .||:|.:||..||.:||:||:.:|:.|  .|.|.:.....|  :|..::|:|::|::| |.:...
  Rat  1250 ADGNPILLTAGSDMKIRFWDLVSPERS--YVVAGSTGSPSV--SYYKKIIEGTEVVQE-IQNKQK 1309

  Fly  1286 TGDSQQLRSSTEENPRSGPDMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK 1342
            .|.|       ::.||.||:.....|||.|||:...:.. |.:|.:|||:|::|:||
  Rat  1310 VGPS-------DDTPRRGPESLPVGHHDIITDIATFQTT-QGFIVTASRDGIVKVWK 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps15NP_649868.1 STKc_Vps15 27..325 CDD:270882 165/309 (53%)
HEAT repeat 436..469 CDD:293787 14/32 (44%)
HEAT repeat 483..508 CDD:293787 13/24 (54%)
HEAT repeat 543..573 CDD:293787 16/29 (55%)
HEAT repeat 583..613 CDD:293787 20/30 (67%)
HEAT repeat 621..650 CDD:293787 18/28 (64%)
WD40 846..1273 CDD:441893 155/473 (33%)
WD40 repeat 1020..1063 CDD:293791 9/46 (20%)
WD40 repeat 1068..1107 CDD:293791 19/38 (50%)
WD40 repeat 1115..1150 CDD:293791 16/34 (47%)
WD40 repeat 1157..1194 CDD:293791 18/36 (50%)
WD40 repeat 1199..1241 CDD:293791 17/41 (41%)
WD40 repeat 1259..1309 CDD:293791 13/49 (27%)
Pik3r4NP_001388143.1 STKc_Vps15 25..320 CDD:270882 165/311 (53%)
HEAT repeat 379..404 CDD:293787 12/24 (50%)
HEAT 1 413..450 16/36 (44%)
HEAT repeat 418..446 CDD:293787 11/27 (41%)
HEAT 2 458..495 21/37 (57%)
HEAT repeat 462..492 CDD:293787 18/30 (60%)
HEAT repeat 539..566 CDD:293787 15/26 (58%)
HEAT 3 572..610 26/37 (70%)
HEAT repeat 576..607 CDD:293787 20/30 (67%)
HEAT 4 612..648 21/35 (60%)
HEAT repeat 614..641 CDD:293787 17/26 (65%)
HEAT repeat 652..682 CDD:293787 13/29 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..899 7/23 (30%)
WD40 <979..1357 CDD:441893 148/392 (38%)
WD 1 991..1030 15/39 (38%)
WD40 repeat 997..1040 CDD:293791 14/43 (33%)
WD 2 1040..1079 6/38 (16%)
WD40 repeat 1045..1091 CDD:293791 9/45 (20%)
WD 3 1093..1134 19/40 (48%)
WD40 repeat 1099..1136 CDD:293791 17/36 (47%)
WD 4 1139..1178 19/38 (50%)
WD40 repeat 1144..1179 CDD:293791 17/34 (50%)
WD 5 1182..1223 19/40 (48%)
WD40 repeat 1187..1236 CDD:293791 24/48 (50%)
WD 6 1237..1278 18/43 (42%)
WD40 repeat 1242..1268 CDD:293791 11/25 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1326 6/25 (24%)
WD 7 1327..1358 13/31 (42%)
WD40 repeat 1332..1357 CDD:293791 10/25 (40%)

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