DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vps15 and PIK3R4

DIOPT Version :10

Sequence 1:NP_649868.1 Gene:Vps15 / 41096 FlyBaseID:FBgn0260935 Length:1342 Species:Drosophila melanogaster
Sequence 2:NP_055417.1 Gene:PIK3R4 / 30849 HGNCID:8982 Length:1358 Species:Homo sapiens


Alignment Length:1417 Identity:590/1417 - (41%)
Similarity:837/1417 - (59%) Gaps:134/1417 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGNQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLP 65
            |||||.|||||||.:||.|||.....|  :..::|||||||||:||..||.:|||||...|||||
Human     1 MGNQLAGIAPSQILSVESYFSDIHDFE--YDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLP 63

  Fly    66 LEDHKERLEGIKKTLSLANAVNCLPFQRV--ELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKK 128
            |..:|:.||.:|  :.|.:|.||||||:.  :..:|||.:.|:||:.:||||:||||||..:||:
Human    64 LTSYKQELEELK--IRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKR 126

  Fly   129 WITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSR 193
            ||.||||.|::|.||..:.|||||.||:::|||||:||:|||||||||||||||||:.|||||||
Human   127 WIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSR 191

  Fly   194 RRTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPS----------YAGNTLLPAMDIFSA 248
            ||||||||||||       |||     :..|:......||          .....|..|||||||
Human   192 RRTCYIAPERFV-------DGG-----MFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSA 244

  Fly   249 GCALLELWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYL 313
            ||.:.||:|||...|:||||||||.| ....|:.|..||:..:|.|:..||......|..|||||
Human   245 GCVIAELFTEGVPLFDLSQLLAYRNG-HFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYL 308

  Fly   314 DQERGQLFPEYFYSFLQSYLQMFSSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEEK 378
            .|:||..|||.||:|||.|:..|:....:|.|::|..:.||:|:.|..|. ..|| ||:.|.|  
Human   309 KQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLC-GHDL-PEKAEGE-- 369

  Fly   379 KDPTLCARLPPEHDGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILH 443
                      |:.:||:::::|:|||::.||..::|:|||||:..|:...:.|.:||||.||:||
Human   370 ----------PKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLH 424

  Fly   444 LAQKSPAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAA 508
            .:..|..:|:.:|:.|||..|.:||::||:|.|::||||||.|..||.: .|.|||:|:|.|||.
Human   425 FSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQD-DATIVRLAYAENIAL 488

  Fly   509 LAKSAVYFLEETQ------RNAPND-------MPTPRYEAELNALHDIVRQAVLSLLTDSQPVVK 560
            ||::|:.|||..|      .|.||:       .|...|:.||.|||::|:|.|::||:|.:.:||
Human   489 LAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVK 553

  Fly   561 QTLMESGICDLCAFFGKEKANDVILSHIMTFLNDE-DKNLRGAFYDNIAGVAGYVGWQASDILVP 624
            |||||:||..||.|||::|||||:|||::|||||: |.:|||||:|:|.|||.|||||:|.||.|
Human   554 QTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKP 618

  Fly   625 LLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTA 689
            |||||.:|.|||||.||:.|:|.:.:||.::||.|.|...:.|.:|||||||:|:...|.|...|
Human   619 LLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVA 683

  Fly   690 RNLSAIDVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEAR 754
            |.:|..||.||:||.:..::..|:||:|:..:||..:..||.|.|||..||.:||....|.|   
Human   684 RQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHL--- 745

  Fly   755 SRVRSQTRQGALPQY---EEMGQTLRNLFRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDD 816
             .:|.:.|.|:||..   |:  ..:..|.::|.|:|:|:..|.:|||:..|::. .:||..::.|
Human   746 -HMRQKKRNGSLPDCPPPED--PAIAQLLKKLLSQGMTEEEEDKLLALKDFMMK-SNKAKANIVD 806

  Fly   817 -----TASGNGRIVVSRKQVACHEYPLADKASKMPLDNRSSEG---------------------- 854
                 .:|..|.|.::...:...:..|. |..:.|.|.|:.:.                      
Human   807 QSHLHDSSQKGVIDLAALGITGRQVDLV-KTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPN 870

  Fly   855 -PTLASPASDAAITPLGAGGLAGSPASGAVVLG----VPTATV-----SAATSLGEYTMPERNCW 909
             |......||..:...|....:.|.|...|.|.    ||..|.     .....|....:|  :.:
Human   871 MPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILP--STY 933

  Fly   910 LERSSECRKDLESLTAKIKSRYNVLAIS----QRCSYDKLVTPYPPGWRMTGTLVAHLHEHSESV 970
            ..|.:.|:.:|:.|..:.:.:.|...|:    :...::.  .|.|||||..|.||||||||..:|
Human   934 QIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWES--KPPPPGWRPKGLLVAHLHEHKSAV 996

  Fly   971 IKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYS-ANTPIYALAACDSGQSLAVG 1034
            .::.....| ||||:.|.||||::|:..|:.|.....:|...|| ....:..|..|.....||:.
Human   997 NRIRVSDEH-SLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIA 1060

  Fly  1035 GKDGSMLMMRIDRN----SAKMTLQQALNQNDHKDGPVVDMHAYDQATQSVIVYATLYGGIVAWD 1095
            ..:|::.::.|:.:    |.|:...|:...:..:||.|||||.::...|||:.|||:.|.:|.||
Human  1061 SDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWD 1125

  Fly  1096 TRMQHSAWRLQNELRHGVITTICADPTGSWLATGTSGGKHICWDLRFRLPIAEIKHPADSWIRKV 1160
            .|...:||.|:::|:.|:||:...|....||..|||.|...|||:||:|||:...||:.:.||::
Human  1126 LRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRL 1190

  Fly  1161 ACHPTEPSYLISASQSNNEVSVWNIETGQRQTVLWASPVAALSSASPSDPATTCGILSGVVDGSP 1225
            :.||...|::|:|.|.|||||:|::|||.|:..||||....||...|| |.:..||.....||:|
Human  1191 SMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPS-PHSVHGIYCSPADGNP 1254

  Fly  1226 FILTGSSDQRIRYWDITNPKNSSLKVPAANDNLADVAFNYGARLIDGSQVIEEQIISMASTGDSQ 1290
            .:||..||.:||:||:..|:.|  .|.|.:.:...|  :|..::|:|::|::| |.:....|.| 
Human  1255 ILLTAGSDMKIRFWDLAYPERS--YVVAGSTSSPSV--SYYRKIIEGTEVVQE-IQNKQKVGPS- 1313

  Fly  1291 QLRSSTEENPRSGPDMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK 1342
                  ::.||.||:.....|||.|||:...:.. |.:|.:|||:|::|:||
Human  1314 ------DDTPRRGPESLPVGHHDIITDVATFQTT-QGFIVTASRDGIVKVWK 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps15NP_649868.1 STKc_Vps15 27..325 CDD:270882 166/309 (54%)
HEAT repeat 436..469 CDD:293787 14/32 (44%)
HEAT repeat 483..508 CDD:293787 13/24 (54%)
HEAT repeat 543..573 CDD:293787 16/29 (55%)
HEAT repeat 583..613 CDD:293787 20/30 (67%)
HEAT repeat 621..650 CDD:293787 18/28 (64%)
WD40 846..1273 CDD:441893 152/467 (33%)
WD40 repeat 1020..1063 CDD:293791 9/46 (20%)
WD40 repeat 1068..1107 CDD:293791 19/38 (50%)
WD40 repeat 1115..1150 CDD:293791 16/34 (47%)
WD40 repeat 1157..1194 CDD:293791 18/36 (50%)
WD40 repeat 1199..1241 CDD:293791 17/41 (41%)
WD40 repeat 1259..1309 CDD:293791 13/49 (27%)
PIK3R4NP_055417.1 STKc_Vps15 25..320 CDD:270882 166/311 (53%)
HEAT repeat 377..408 CDD:293787 13/30 (43%)
HEAT 1 413..450 16/36 (44%)
HEAT repeat 417..443 CDD:293787 11/25 (44%)
HEAT 2 458..495 21/37 (57%)
HEAT repeat 460..489 CDD:293787 18/29 (62%)
HEAT repeat 539..566 CDD:293787 15/26 (58%)
HEAT 3 572..610 26/37 (70%)
HEAT repeat 576..607 CDD:293787 20/30 (67%)
HEAT repeat 614..641 CDD:293787 17/26 (65%)
HEAT repeat 652..682 CDD:293787 13/29 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..898 5/22 (23%)
WD40 <979..1357 CDD:441893 149/392 (38%)
WD 1 991..1030 16/39 (41%)
WD40 repeat 997..1040 CDD:293791 15/43 (35%)
WD 2 1040..1079 6/38 (16%)
WD40 repeat 1045..1091 CDD:293791 9/45 (20%)
WD 3 1093..1134 19/40 (48%)
WD40 repeat 1099..1136 CDD:293791 17/36 (47%)
WD 4 1139..1178 19/38 (50%)
WD40 repeat 1144..1179 CDD:293791 17/34 (50%)
WD 5 1182..1223 19/40 (48%)
WD40 repeat 1187..1236 CDD:293791 24/48 (50%)
WD 6 1237..1278 18/43 (42%)
WD40 repeat 1242..1268 CDD:293791 11/25 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1326 6/25 (24%)
WD 7 1327..1358 13/31 (42%)
WD40 repeat 1332..1357 CDD:293791 10/25 (40%)

Return to query results.
Submit another query.