| Sequence 1: | NP_649868.1 | Gene: | Vps15 / 41096 | FlyBaseID: | FBgn0260935 | Length: | 1342 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_055417.1 | Gene: | PIK3R4 / 30849 | HGNCID: | 8982 | Length: | 1358 | Species: | Homo sapiens |
| Alignment Length: | 1417 | Identity: | 590/1417 - (41%) |
|---|---|---|---|
| Similarity: | 837/1417 - (59%) | Gaps: | 134/1417 - (9%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MGNQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLP 65
Fly 66 LEDHKERLEGIKKTLSLANAVNCLPFQRV--ELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKK 128
Fly 129 WITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSR 193
Fly 194 RRTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPS----------YAGNTLLPAMDIFSA 248
Fly 249 GCALLELWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYL 313
Fly 314 DQERGQLFPEYFYSFLQSYLQMFSSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEEK 378
Fly 379 KDPTLCARLPPEHDGLILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRILPYILH 443
Fly 444 LAQKSPAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASETSAVIVRVAFARNIAA 508
Fly 509 LAKSAVYFLEETQ------RNAPND-------MPTPRYEAELNALHDIVRQAVLSLLTDSQPVVK 560
Fly 561 QTLMESGICDLCAFFGKEKANDVILSHIMTFLNDE-DKNLRGAFYDNIAGVAGYVGWQASDILVP 624
Fly 625 LLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTA 689
Fly 690 RNLSAIDVQCKIMPAIGAFLKAPLIQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEAR 754
Fly 755 SRVRSQTRQGALPQY---EEMGQTLRNLFRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDD 816
Fly 817 -----TASGNGRIVVSRKQVACHEYPLADKASKMPLDNRSSEG---------------------- 854
Fly 855 -PTLASPASDAAITPLGAGGLAGSPASGAVVLG----VPTATV-----SAATSLGEYTMPERNCW 909
Fly 910 LERSSECRKDLESLTAKIKSRYNVLAIS----QRCSYDKLVTPYPPGWRMTGTLVAHLHEHSESV 970
Fly 971 IKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYS-ANTPIYALAACDSGQSLAVG 1034
Fly 1035 GKDGSMLMMRIDRN----SAKMTLQQALNQNDHKDGPVVDMHAYDQATQSVIVYATLYGGIVAWD 1095
Fly 1096 TRMQHSAWRLQNELRHGVITTICADPTGSWLATGTSGGKHICWDLRFRLPIAEIKHPADSWIRKV 1160
Fly 1161 ACHPTEPSYLISASQSNNEVSVWNIETGQRQTVLWASPVAALSSASPSDPATTCGILSGVVDGSP 1225
Fly 1226 FILTGSSDQRIRYWDITNPKNSSLKVPAANDNLADVAFNYGARLIDGSQVIEEQIISMASTGDSQ 1290
Fly 1291 QLRSSTEENPRSGPDMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK 1342 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Vps15 | NP_649868.1 | STKc_Vps15 | 27..325 | CDD:270882 | 166/309 (54%) |
| S_TKc | 41..311 | CDD:214567 | 149/281 (53%) | ||
| HEAT repeat | 436..469 | CDD:293787 | 14/32 (44%) | ||
| HEAT repeat | 483..508 | CDD:293787 | 13/24 (54%) | ||
| HEAT repeat | 543..573 | CDD:293787 | 16/29 (55%) | ||
| HEAT repeat | 583..613 | CDD:293787 | 20/30 (67%) | ||
| HEAT repeat | 621..650 | CDD:293787 | 18/28 (64%) | ||
| WD40 | 953..1240 | CDD:295369 | 117/291 (40%) | ||
| WD40 | <958..1342 | CDD:225201 | 146/388 (38%) | ||
| WD40 repeat | 1020..1063 | CDD:293791 | 9/46 (20%) | ||
| WD40 repeat | 1068..1107 | CDD:293791 | 19/38 (50%) | ||
| WD40 repeat | 1115..1150 | CDD:293791 | 16/34 (47%) | ||
| WD40 repeat | 1157..1194 | CDD:293791 | 18/36 (50%) | ||
| WD40 repeat | 1199..1241 | CDD:293791 | 17/41 (41%) | ||
| WD40 repeat | 1259..1309 | CDD:293791 | 13/49 (27%) | ||
| PIK3R4 | NP_055417.1 | STKc_Vps15 | 25..320 | CDD:270882 | 166/311 (53%) |
| S_TKc | 26..309 | CDD:214567 | 159/299 (53%) | ||
| DRIM | <352..>448 | CDD:284870 | 40/109 (37%) | ||
| HEAT repeat | 377..408 | CDD:293787 | 13/30 (43%) | ||
| HEAT 1 | 413..450 | 16/36 (44%) | |||
| HEAT repeat | 417..443 | CDD:293787 | 11/25 (44%) | ||
| HEAT 2 | 458..495 | 21/37 (57%) | |||
| HEAT repeat | 460..489 | CDD:293787 | 18/29 (62%) | ||
| HEAT repeat | 539..566 | CDD:293787 | 15/26 (58%) | ||
| HEAT 3 | 572..610 | 26/37 (70%) | |||
| HEAT repeat | 576..607 | CDD:293787 | 20/30 (67%) | ||
| HEAT repeat | 614..641 | CDD:293787 | 17/26 (65%) | ||
| HEAT repeat | 652..682 | CDD:293787 | 13/29 (45%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 875..898 | 5/22 (23%) | |||
| WD40 | 985..1269 | CDD:295369 | 114/285 (40%) | ||
| WD40 | 991..1358 | CDD:225201 | 140/381 (37%) | ||
| WD 1 | 991..1030 | 16/39 (41%) | |||
| WD40 repeat | 997..1040 | CDD:293791 | 15/43 (35%) | ||
| WD 2 | 1040..1079 | 6/38 (16%) | |||
| WD40 repeat | 1045..1091 | CDD:293791 | 9/45 (20%) | ||
| WD 3 | 1093..1134 | 19/40 (48%) | |||
| WD40 repeat | 1099..1136 | CDD:293791 | 17/36 (47%) | ||
| WD 4 | 1139..1178 | 19/38 (50%) | |||
| WD40 repeat | 1144..1179 | CDD:293791 | 17/34 (50%) | ||
| WD 5 | 1182..1223 | 19/40 (48%) | |||
| WD40 repeat | 1187..1236 | CDD:293791 | 24/48 (50%) | ||
| WD 6 | 1237..1278 | 18/43 (42%) | |||
| WD40 repeat | 1242..1268 | CDD:293791 | 11/25 (44%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1307..1326 | 6/25 (24%) | |||
| WD 7 | 1327..1358 | 13/31 (42%) | |||
| WD40 | <1327..1358 | CDD:197651 | 13/31 (42%) | ||
| WD40 repeat | 1332..1357 | CDD:293791 | 10/25 (40%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165155704 | |
| Domainoid | 1 | 1.000 | 421 | 1.000 | Domainoid score | I630 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1240 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H24678 | |
| Inparanoid | 1 | 1.050 | 995 | 1.000 | Inparanoid score | I304 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S2775 |
| OMA | 1 | 1.010 | - | - | QHG58143 | |
| OrthoDB | 1 | 1.010 | - | - | D1312453at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0004354 | |
| OrthoInspector | 1 | 1.000 | - | - | oto89349 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | LDO | PTHR17583 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R969 |
| SonicParanoid | 1 | 1.000 | - | - | X3072 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.850 | |||||