DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps15 and vps-15

DIOPT Version :9

Sequence 1:	NP_649868.1	Gene:	Vps15 / 41096	FlyBaseID:	FBgn0260935	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001254322.1	Gene:	vps-15 / 174827	WormBaseID:	WBGene00014151	Length:	1354	Species:	Caenorhabditis elegans

Alignment Length:	1478	Identity:	390/1478 - (26%)
Similarity:	646/1478 - (43%)	Gaps:	260/1478 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG--NQLVGIAPSQIYAVEHYFSGQFGSEIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPT 63
            ||  |.|....||:|..||.|.:......:   .|:|||||.|||:.:|.||..|.||||:.| .
Worm     1 MGNINSLFTTNPSEILPVEVYLNDLSCDAV---ENLGSTRFMKVARGRTHEGVFVYKVFVRQD-L 61

  Fly    64 LPLEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKK 128
            ..|:...:|:..|:|  :|..:.||.|.::|.:..|.|.::|.:.||:|:||:|||||:...||.
Worm    62 ASLDPFPQRIIDIRK--ALMKSPNCCPIKKVLVKQKYAVMVRAFQKHTLFDRLSTRPFVVEAEKM 124

  Fly   129 WITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSR 193
            |..|.:..||:||....:||||:|.:|:||:|.||:.::|||.|||.:|..|||:.:|:||||||
Worm   125 WYIFLLFKALSQCETAGVCHGDLKSQNVLISSTNWLQITDFAPFKPCFLTHDNPSSFTFFFDTSR 189

  Fly   194 RRTCYIAPERFVKTLASDDDGGNGNMSVIHTDSIIRLAPSYAGNTLLPAMDIFSAGCALLELWTE 258
            |::||||||||:.....|:...:|.             ..:...:|.|.||:|||||.:.||..:
Worm   190 RQSCYIAPERFISATEYDEKLRDGQ-------------DEWLFGSLTPKMDMFSAGCIVFELLCD 241

  Fly   259 GTAPFELSQLLAYR-RGERDLVEKHLAGIEN--ERLRNLLASMIDIHSMNRKSAEDYLDQERGQL 320
             ..||..|.|..|| ..:.|.....|..|::  ...|.||..:::.....|.||...| ......
Worm   242 -RPPFTYSSLCEYRSMNDADAGNMLLRLIQDVPAPYRPLLRLLLNRDPSFRISANAVL-TGAALK 304

  Fly   321 FPEYFYSFLQSYLQMF--------SSTPIMSPDDKIQCLHKDIGHCIKVLTQAQDLTPEEEEKEE 377
            ||....|||..||..|        ||.|  |.||..|.|            :...|.|::...:.
Worm   305 FPHILESFLFKYLDRFRPLYGTSTSSDP--STDDFSQAL------------EFSYLEPDDVITKL 355

  Fly   378 KKDPTL-CARLPPEHDG---LILIITVVTSCIRGLKQSNTKIAALELLQKLSKYTTSETILDRIL 438
            |::..| .|||....:.   ..|.::::|:.:|.|:....|..|:.:|.:||..:.|...:||||
Worm   356 KREKQLWWARLSENDESKSFAFLFVSLITANLRALRTIQGKTDAIRMLVELSTISDSSVAIDRIL 420

  Fly   439 PYILHLAQKSPAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSITDLASET--SAVIVRVA 501
            ||.:||......:|:..|:..:...|..::.....::.||.:|:.|.:..:::::  |...|..|
Worm   421 PYFVHLWMDPETQVRATAVTAVAELLAPIQPKTYEESLVFVDYLFPHLNSMSNDSIDSPQHVLFA 485

  Fly   502 FARNIAALAKSAVYFL----EETQRNAPNDMPTPRYEAELN-----ALHDIVRQAVLSLLTDSQP 557
            .|.::...|.:|..|.    |..|....:|..:...|.:.|     .||.:  .|:.|.|...:|
Worm   486 IATSLGQFADTAYRFYMAGREIRQATMYDDEVSTAGEQQQNDDAGALLHGV--SAMFSALCSKEP 548

  Fly   558 VVKQTLMES-GICDLCAFFGKEKANDVILSHIMTFLNDEDK-NLRGAFYDNIAGVAGYVGWQASD 620
            :||:.|:|| .:..|..||.|...:|.:|..:.||||.:.: .||.||:|::....    .:.|:
Worm   549 MVKRCLVESKSLILLYHFFIKIGNDDTLLRFLCTFLNAKTEWRLRAAFFDSLPVCV----QKRSE 609

  Fly   621 ILVPLLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMI 685
            .:|||||.|..|.||.|:.:|:..:.|||:..::.|.:|.:::.:...:|.|||.|:|..:|.::
Worm   610 GMVPLLQLGLQDGEEHVVVRALGCIHILIKNENLDKMSVKKLLDDVLPFLVHPNDWIRSTVCDIL 674

  Fly   686 ATTARNLSAIDVQCKIMPAIGAFL---KAPLIQVEKPHILLDCVHPPVPRQIFDSVL-------- 739
            ..........:|..|::|.:..|:   |..::.::...:|:..:..|:||..|:.::
Worm   675 LAIDCQWHNAEVHVKLIPLVSPFVEESKRGVLTLKSKPVLMSQLVDPIPRTTFNQIIDQSLENTK 739

  Fly   740 ---RFQDIHHFI-RALEARS--------RVRSQTRQGALPQYEEMGQTL-------------RNL 779
               ...:||... :..||.:        :::::|:.|.: ::.::...|             |.|
Worm   740 QITMLLEIHFQTGKPFEAGAGWFNTIFPKIKTETKAGVV-EHNDLKAALEARKRLTASVYSFRKL 803

  Fly   780 FRRLSSEGLTDLIEMQLLAMNPFLISMKHKALQDLDDTASGNGRIVVSRKQVACHEYPLADKASK 844
            |.|::....|..:|:.|.           :.|..:|.::..:.|  |.||     |:......|.
Worm   804 FERMAETRNTAGMEIYLT-----------RQLGTIDLSSIAHSR--VRRK-----EFTYGGDESA 850

  Fly   845 MPLDNRSSEGPTLASPASDAAITPLGAGGLAGSPASGAVVLGVPTATVSAAT----------SLG 899
            |..:::......:.:.:::...|.|.||.:.............|.:.|...|          .|.
Worm   851 MSSNSKHLTAINIPNHSTERRDTLLLAGEVVIEEERTVTNTPAPYSPVKNTTFDNQVNEMLAHLN 915

  Fly   900 EYTMPERNCWLERSSECRKDLESLTAK-------IKSRYNVLAISQRCSYDKLVTPYPPGWRMTG 957
            |..|...||..:|..........|:|.       ..|..||                      .|
Worm   916 ELHMRNVNCRPKRPLAASASHPVLSASPSAGSLGSSSNNNV----------------------KG 958

  Fly   958 TLVAHLHEHSESVIKLASLRPHGSLFASGSIDGTVRLWDCSKLNGNQGVNKSRQVYSANTPIYAL 1022
            .::.||||||..:.||.:.| ...||.|||.||||::|....:.| :|...:|   |.:|.|...
Worm   959 IIITHLHEHSGKITKLCANR-ESDLFLSGSTDGTVKVWKTRSVLG-EGYGSAR---SEDTWIPTE 1018

  Fly  1023 AACDSGQSLAVGGK-------DGSMLMMRIDRNSAKMTLQQALNQNDHKDGPVVDMHAYDQATQS 1080
            .:.:...|:....:       ||.:....:.:.||::..|..:   ...:||.|.:|    ....
Worm  1019 TSREKVNSVGWNDQFACSATNDGFVRWADVGQGSARVATQVRI---PDAEGPPVYLH----CNGP 1076

  Fly  1081 VIVYATLYGGIVAWDTRM--------QHSAWRLQNELRHGVITTICADP-TGSWLATGTSGGKH- 1135
            :.:..|.:|.:...|.|:        :|..||.:.:..||::|:...|| ..||:..|.:.|:.
Worm  1077 MAIVRTHHGVLYGIDLRVGASEGPLKRHDIWRKKFQESHGLVTSSAIDPWQQSWMVIGNNSGQKN 1141

  Fly  1136 -ICWDLRFRLPIAEIKHPADS------WIRKVA---CHPTEPSYLISASQSNNEVSVWNIETGQ- 1189
             :.:||||:..:...:.|..:      |...|:   |    |...:..|. :.|:|.:.:....
Worm  1142 LVLYDLRFKEEVLRWESPHQNTQPNRVWANPVSRQEC----PEVFVGFSM-HGEISTYELSAQPL 1201

  Fly  1190 RQTVLW--ASPVAALSSAS----PSDPATTCGILSGVVDGSPFILTGSSDQRIRYWDITNPKNSS 1248
            |:.|.|  .:|:.:.|:||    ..|...|..:.  |.:.:..:.||.:...||.|   ||..:
Worm  1202 RKRVFWTGGAPILSYSAASNDARKQDSLATRSLC--VCEKTGVVYTGDTRGAIRKW---NPTRA- 1260

  Fly  1249 LKVPAANDNLADVAFNYGARLIDG--------SQVIEEQIISMASTGDSQQ---------LRSST 1296
                            .|..:|..        ..:.||...|.|.:|.|..         |.:..
Worm  1261 ----------------VGCEIISAPPKGRTAYRTIFEENDTSTAPSGASTDPFVIYERTVLDTEA 1309

  Fly  1297 EENPRSGP--DMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK 1342
            :||.:..|  ..|:..|...|||:::...:   .:.|:..:||||:||
Worm  1310 KENQKVVPLDSKPSTYHRTPITDMMLLNSE---LLVSSGYDGVIKIWK 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps15	NP_649868.1	STKc_Vps15	27..325	CDD:270882	116/300 (39%)
		S_TKc	41..311	CDD:214567	107/272 (39%)
		HEAT repeat	436..469	CDD:293787	10/32 (31%)
		HEAT repeat	483..508	CDD:293787	5/26 (19%)
		HEAT repeat	543..573	CDD:293787	10/30 (33%)
		HEAT repeat	583..613	CDD:293787	10/30 (33%)
		HEAT repeat	621..650	CDD:293787	13/28 (46%)
		WD40	953..1240	CDD:295369	78/320 (24%)
		WD40	<958..1342	CDD:225201	102/436 (23%)
		WD40 repeat	1020..1063	CDD:293791	6/49 (12%)
		WD40 repeat	1068..1107	CDD:293791	9/46 (20%)
		WD40 repeat	1115..1150	CDD:293791	11/37 (30%)
		WD40 repeat	1157..1194	CDD:293791	7/40 (18%)
		WD40 repeat	1199..1241	CDD:293791	11/45 (24%)
		WD40 repeat	1259..1309	CDD:293791	13/68 (19%)
vps-15	NP_001254322.1	STKc_Vps15	20..324	CDD:270882	123/324 (38%)
		SPS1	30..382	CDD:223589	138/386 (36%)
		HEAT repeat	418..448	CDD:293787	10/29 (34%)
		HEAT repeat	457..492	CDD:293787	8/34 (24%)
		HEAT repeat	540..565	CDD:293787	9/24 (38%)
		HEAT repeat	575..601	CDD:293787	10/25 (40%)
		HEAT repeat	610..636	CDD:293787	11/25 (44%)
		HEAT repeat	647..674	CDD:293787	8/26 (31%)
		WD40	<948..>1053	CDD:225201	32/131 (24%)
		WD40	957..996	CDD:197651	19/39 (49%)
		WD40 repeat	971..1017	CDD:293791	19/50 (38%)
		WD40 repeat	1067..1105	CDD:293791	7/41 (17%)
		WD40 repeat	1118..1153	CDD:293791	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164152
Domainoid	1	1.000	178	1.000	Domainoid score	I2133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	424	1.000	Inparanoid score	I985
Isobase	1	0.950	-	0	Normalized mean entropy	S2775
OMA	1	1.010	-	-		QHG58143
OrthoDB	1	1.010	-	-		D1312453at2759
OrthoFinder	1	1.000	-	-		FOG0004354
OrthoInspector	1	1.000	-	-		oto19208
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17583
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R969
SonicParanoid	1	1.000	-	-		X3072
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.990