DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pum and PUM2

DIOPT Version :9

Sequence 1:	NP_001262403.1	Gene:	pum / 41094	FlyBaseID:	FBgn0003165	Length:	1533	Species:	Drosophila melanogaster
Sequence 2:	NP_001189630.1	Gene:	PUM2 / 817468	AraportID:	AT2G29190	Length:	972	Species:	Arabidopsis thaliana

Alignment Length:	1048	Identity:	316/1048 - (30%)
Similarity:	453/1048 - (43%)	Gaps:	263/1048 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 GIDDDKGFNRTPGSRQPSPAEESQ-PRPPNLL----FPPLPFNHMLMDHGQGMGGGLGGVVGSGN 586
            |.|.:|......|.:|....|..: .|..||.    .||..         .|.....||:...|.
plant    20 GDDYEKEIGVLLGEQQRRQVEADELERELNLYRSGSAPPTV---------DGSVSAAGGLFSGGG 75

  Fly   587 GV-----GGGSGGGGAGG---------AYAAHQQMAAQMS-QLQPPMMNGVGGGMPMAAQSPMLN 636
            |.     |||:.|.|.||         ||.::.....::: :|.||:|:               .
plant    76 GAPFLEFGGGNKGNGFGGDDEEFRKDPAYLSYYYANMKLNPRLPPPLMS---------------R 125

  Fly   637 HQAAGPNHMESPGNLL-----QQQNFDVQQLFRSQNPGLAAVATNAAAAAAAAAAATSAASAAAA 696
            ........::...|:|     :::..|.|.|| |..||.
plant   126 EDLRVAQRLKGSSNVLGGVGDRRKVNDSQSLF-SMPPGF-------------------------- 163

  Fly   697 VGAPPVPNGSLQQSQQQQQQQQQQQQQQQMHMAAASQQFLAAQQQAQNAAYAAQQATSYVINPGQ 761
                                .|::|.:.::...:||.....|.                    |.
plant   164 --------------------DQRKQHEFEVEKTSASSSEWDAN--------------------GL 188

  Fly   762 EAAPYMGMIAAAQMPYYGVAPWGMYPGNLIPQQGTQP------------RRPLTPS-QQG-AENQ 812
            ...|.:| |...|..:..:....|..|:.:.:|.::|            :..|:|| .|| ....
plant   189 IGLPGLG-IGGKQKSFADIFQADMGHGHPVTKQPSRPASRNTFDENVDSKNNLSPSASQGIGAPS 252

  Fly   813 PYQVIPAFLDHTGSLLMGGPRTGTP-----MRLVSPAPVLVPPGATRAGPPPPQGPQLYQP---- 868
            ||    ::....||.|   .|.|||     .|:  |:|.|.|.|:.|......:......|
plant   253 PY----SYAAVLGSSL---SRNGTPDPQAIARV--PSPCLTPIGSGRVSSNDKRNTSNQSPFNGG 308

  Fly   869 -QPQTAQQNLYSQQNGSSVGGL-------------------------ALNTSSLTGRRDSFDRST 907
             ...:...|..|..|.|..|||                         .:|......:.|...::|
plant   309 LNESSDLVNALSGMNLSGSGGLDERGQAEQDVEKVRNYMFGLQGGHNEVNQHGFPNKSDQAQKAT 373

  Fly   908 SAFSPSTM------DYTSSGVAAAA-------------NAVNSTVAQAAA------------AAA 941
            .....|.:      .|...|..|..             ..:|..||...|            ..|
plant   374 GLLRNSQLRGAQGSTYNDGGGVATQYQHLDSPNYCLNNYGLNPAVASMMANQLGTNNYSPVYENA 438

  Fly   942 AAAAARGKWPGAMSGAASGAYGA------------------LGAGNASASPLGAP---------- 978
            :||:|.| :.|..|....|.|.:                  :|.|....|.:..|
plant   439 SAASAMG-FSGMDSRLHGGGYVSSGQNLSESRNLGRFSNRMMGGGTGLQSHMADPMYHQYADSLD 502

  Fly   979 ITPPPSAQSCLLGSRAPGAESRQRQQQQQQLAAVGLPATAAAAQAAVAAAANNMFGSNS--SIFS 1041
            :...||.....:|:........||.....|.:..|:|..:.:..      ::..:||.:  |...
plant   503 LLNDPSMDVNFMGNSYMNMLELQRAYLGAQKSQYGVPYKSGSPN------SHTDYGSPTFGSYPG 561

  Fly  1042 NPLA---IPGTAAVAAAAAAAAAANSRQVAATAAAAAAV-------AAAAGGVGGAPQPGRSRLL 1096
            :|||   :|.:.....:.......|.|..:||...|..|       |:...|.|       |.:|
plant   562 SPLAHHLLPNSLVSPCSPMRRGEVNMRYPSATRNYAGGVMGSWHMDASLDEGFG-------SSML 619

  Fly  1097 EDFRNQRYPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATAAEKQMVFSEILAAAYSLMTDVFG 1161
            |:|::.:....:|.::|.|:||||.||:||||||||||.||:.||.||:.||:..|.:|||||||
plant   620 EEFKSNKTRGFELAEIAGHVVEFSSDQYGSRFIQQKLETATSDEKNMVYEEIMPHALALMTDVFG 684

  Fly  1162 NYVIQKFFEFGTPEQKNTLGMQVKGHVLQLALQMYGCRVIQKALESISPEQQQEIVHELDGHVLK 1226
            |||||||||.|.|.|:..|..::..:||.|:||||||||||||:|.:..:|:.::|.||||||::
plant   685 NYVIQKFFEHGLPPQRRELADKLFDNVLPLSLQMYGCRVIQKAIEVVDLDQKIKMVKELDGHVMR 749

  Fly  1227 CVKDQNGNHVVQKCIECVDPVALQFIINAFKGQVYSLSTHPYGCRVIQRILEHCTAEQT-TPILD 1290
            ||:|||||||||||||||....::|||:.|.|.|.:|||||||||||||:||||....| :.::|
plant   750 CVRDQNGNHVVQKCIECVPEENIEFIISTFFGNVVTLSTHPYGCRVIQRVLEHCHDPDTQSKVMD 814

  Fly  1291 ELHEHTEQLIQDQYGNYVIQHVLEHGKQEDKSILINSVRGKVLVLSQHKFASNVVEKCVTHATRG 1355
            |:......|.|||||||||||||||||.::::::|..:.||::.:||.||||||||||:|.....
plant   815 EIMSTISMLAQDQYGNYVIQHVLEHGKPDERTVIIKELAGKIVQMSQQKFASNVVEKCLTFGGPE 879

  Fly  1356 ERTGLIDEV--CTFNDNALHVMMKDQYANYVVQKMIDVSEPTQLKKLMTKIRPHMAALRKYTYGK 1418
            ||..|::|:  .|..:..|..|||||:|||||||:::..:..|.:.::.:|:.|:.||:||||||
plant   880 EREFLVNEMLGTTDENEPLQAMMKDQFANYVVQKVLETCDDQQRELILGRIKVHLNALKKYTYGK 944

  Fly  1419 HINAKLEK 1426
            ||.|::||
plant   945 HIVARVEK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pum	NP_001262403.1	Pumilio	1106..1424	CDD:153420	181/320 (57%)
PUM2	NP_001189630.1	NABP	277..632	CDD:285264	67/370 (18%)
PUM2	NP_001189630.1	Pumilio	635..950	CDD:153420	180/314 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5099
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2436
orthoMCL	1	0.900	-	-		OOG6_100436
Panther	1	1.100	-	-	O	PTHR12537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X849
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770