DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ada and adal

DIOPT Version :9

Sequence 1:	NP_649866.1	Gene:	Ada / 41092	FlyBaseID:	FBgn0037661	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001028916.1	Gene:	adal / 619263	ZFINID:	ZDB-GENE-050913-145	Length:	348	Species:	Danio rerio

Alignment Length:	327	Identity:	123/327 - (37%)
Similarity:	196/327 - (59%)	Gaps:	17/327 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLKGLPKVELHAHLNGSLGIKSLCDLGERLYGTSCKDFLKLCAHFSRFEKDMDACFEKFAFVHEL 68
            |.:.|||||||||||||:..:::..|.:|....:.:..:.......|  :.:|.||:.|..:|:|
Zfish     8 FYRQLPKVELHAHLNGSVSFETMEKLIKRKPHLNIEHSMTAIRRGQR--RTLDECFQVFKVIHQL 70

  Fly    69 TSTREGLRFATELAIRDFAEDNVQYVEMRTTPK--ANENYSRRDYLQIVIDAIKAASETYPEITV 131
            ..:.|.:....:..|::||.|.|:|:|:|:||:  .....|::.|::.|::||:...:...:|.|
Zfish    71 VDSEEDILMVAKSVIQEFAADGVKYLELRSTPREVTETGLSKQRYIETVLEAIRQCKQEGVDIDV 135

  Fly   132 KLLPSINRAEPVDVAEETVSLAVELARAHPNLILGIDLSGNPGKGRFSDFAPILAQARDKGLKLA 196
            :.|.:::|....:||.:||.||.:...:....::|:||||:|..|...|....|.:|::.|||||
Zfish   136 RFLVAVDRRHGPEVAMQTVKLAEDFLLSSDGTVVGLDLSGDPTVGHGKDLLAALQKAKNCGLKLA 200

  Fly   197 IHCAEIENPSEVKE---MLHFGMSRCGHGTFLTPEDIG-------QLKQRNIAIECCLTSNVKSG 251
            :|.:|:  ||::.|   :|:....|.||||||.| |:|       ::.::||.||.|||||||..
Zfish   201 LHLSEV--PSQIDETELLLNLPPDRIGHGTFLHP-DVGGSDSLVDKVCKQNIPIEICLTSNVKGQ 262

  Fly   252 TVPSLEEHHLKRIMEADAPKVICTDDSGVFDTTLTKEFLIAAETFGLTREQCIDLTLEAVHHSFA 316
            ||||.::||.|.......|.|:||||.|||.|.|::|:.:||.|||||:|....|:.:|:.::||
Zfish   263 TVPSYDKHHFKYWYNRGHPCVLCTDDKGVFCTDLSQEYQLAASTFGLTKEAVWILSQQAIGYTFA 327

  Fly   317 SE 318
            .|
Zfish   328 PE 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	122/323 (38%)
adal	NP_001028916.1	ADA_AMPD	12..339	CDD:238250	122/323 (38%)
adal	NP_001028916.1	N(6)-methyl-AMP binding. /evidence=ECO:0000250\|UniProtKB:Q8LPL7	100..103		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595075
Domainoid	1	1.000	214	1.000	Domainoid score	I2688
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13827
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3587
OMA	1	1.010	-	-		QHG57829
OrthoDB	1	1.010	-	-		D511781at33208
OrthoFinder	1	1.000	-	-		FOG0006051
OrthoInspector	1	1.000	-	-		oto38656
orthoMCL	1	0.900	-	-		OOG6_103864
Panther	1	1.100	-	-	LDO	PTHR11409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R23
SonicParanoid	1	1.000	-	-		X4344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800