Protein Alignment Ada and AMPD1

DIOPT Version :10

• Sequence 1: NP_649866.1
• Gene: Ada / 41092
• FlyBaseID: FBgn0037661
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_000027.3
• Gene: AMPD1 / 270
• HGNCID: 468
• Length: 747
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 90/431 - (20%)
• Similarity: 151/431 - (35%)
• Gaps: 129/431 - (29%)

  Fly    10 KVELHAHLNGSLGIKSL---------CDLGERLYGTSCKD------FLKLCAH------------ 47
            ||:.|.|....:..|.|         .|....:|.|..|:      |.||..|
Human   299 KVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVH 363

  Fly    48 -----FSRFEKDMD-----ACFEKFAFVHELTSTREGLRFAT---ELAIRDFAEDNVQYVEMRTT 99
                 |.||:|..|     ...|......:..:...|..|||   |:. .|..|...|:.|.|.:
Human   364 AGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVG-ADLVEAKYQHAEPRLS 427

  Fly   100 --PKANENYSRRDYLQIVIDAIKAASETY----PEI-----TVKLLPSINRAEP---VDVAEETV 150
              .::.:.:|:.. ...|.:.|...:.|:    |.|     :...||...:...   :.|.|.|:
Human   428 IYGRSPDEWSKLS-SWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATI 491

  Fly   151 SLAVELARAHPNL------ILGID------------------------LSGNPGKGRFS--DFAP 183
            :     .:|.|.|      |.|.|                        |..||....::  .:|.
Human   492 N-----PQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYAN 551

  Fly   184 IL---AQARDKGLKLAI---HCAEIENPSEVKEMLHFGMS-RCGHGTFLTPEDIGQ----LKQRN 237
            |:   :..:::|:...:   ||.|....:.:  |..|.:: ...||..|....:.|    |.|..
Human   552 IMVLNSLRKERGMNTFLFRPHCGEAGALTHL--MTAFMIADDISHGLNLKKSPVLQYLFFLAQIP 614

  Fly   238 IAIECCLTSN------VKSGTVPSLEEHHLKRIMEADAPKVICTDDSGVFDTT---LTKEFLIAA 293
            ||:. .|::|      .|:..:..|:    |.:|.:     :.|||...|..|   |.:|:.|||
Human   615 IAMS-PLSNNSLFLEYAKNPFLDFLQ----KGLMIS-----LSTDDPMQFHFTKEPLMEEYAIAA 669

  Fly   294 ETFGLTREQCIDLTLEAVHHSFASEQEQIQ-MADRVGNYAD 333
            :.|.|:.....::...:|.....|.:|::: :.|   ||.:
Human   670 QVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGD---NYLE 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	87/423 (21%)
AMPD1	NP_000027.3	AMP_deaminase	113..745	CDD:437158	90/431 (21%)