DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ada and Ampd3

DIOPT Version :9

Sequence 1:	NP_649866.1	Gene:	Ada / 41092	FlyBaseID:	FBgn0037661	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001359370.1	Gene:	Ampd3 / 11717	MGIID:	1096344	Length:	775	Species:	Mus musculus

Alignment Length:	439	Identity:	80/439 - (18%)
Similarity:	137/439 - (31%)	Gaps:	139/439 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEQF--LKGLP--------KVELHAHLNGSLGIKSLC-----------------DLGERLYGTSC 38
            |.:|  ||..|        ||:.|.|....:..|.|.                 .||.::.....
Mouse   302 MSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKLGRKITLRQV 366

  Fly    39 KDFLKLCAHFSRFEKDMDAC-----------FEKF---------AFVHELTSTREG-------LR 76
            .|.|    |...::..:|:.           |:||         :.:.:|....|.       .|
Mouse   367 FDSL----HMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFAR 427

  Fly    77 FATELAIRDFAEDNVQYVEMR-----TTPKANENYSR------------RDYLQI--VIDAIKAA 122
            ...|:| |:..:...||.|.|     .:||...:.:|            |..:|:  :.|..::.
Mouse   428 MVKEVA-RELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSK 491

  Fly   123 SETYPEITVKLLPSINRAEPVDVAEETVSLAVELARAHP----------NLILGIDLSGNPGK-- 175
                     ||||:..:      ..|.:.|.:..|..:|          ..:.|.|...:..|
Mouse   492 ---------KLLPNFGK------MLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHS 541

  Fly   176 -GRFSDFAP-------------------------ILAQ-ARDKGLKLAI---HCAEIENPSEVKE 210
             ..|||.:|                         :|.. .|::||...:   ||.|..:.:.:..
Mouse   542 DHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVS 606

  Fly   211 MLHFGMSRCGHGTFLTPEDIGQLKQRNIAIECCLTSNVKSGTVPSLEEHHLKRIMEADAPKVICT 275
            .. .......||..|....:.|.......|...::....:.......::.|:..:.......:.|
Mouse   607 AF-LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLST 670

  Fly   276 DDSGVFDTT---LTKEFLIAAETFGLTREQCIDLTLEAVHHSFASEQEQ 321
            ||...|..|   |.:|:.|||:.:.|:.....::...:|..|..|.||:
Mouse   671 DDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	76/430 (18%)
Ampd3	NP_001359370.1	AMP_deaminase	155..761	CDD:273618	80/439 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810