DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment beag and Wdr55

DIOPT Version :9

Sequence 1:	NP_649865.1	Gene:	beag / 41091	FlyBaseID:	FBgn0037660	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_080740.2	Gene:	Wdr55 / 67936	MGIID:	1915186	Length:	388	Species:	Mus musculus

Alignment Length:	238	Identity:	50/238 - (21%)
Similarity:	89/238 - (37%)	Gaps:	68/238 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KQEDVKLQELSEKYRDRARERRDGANPDYVNVSTPGHGSSTNAYR--AVAPDMKSGI-----DAQ 147
            ::||:...:.:.:.||         .|:.:.:..|..|.:.:..|  ..|.|:...:     ..|
Mouse    16 EEEDLDSTKAAPRIRD---------TPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQ 71

  Fly   148 ERRRRIIQESKFLGGDIQHTHLVKGLDYALLQKVRSELHSKEAEEEEIAAAVAREKLAEAAAAAE 212
            |      .|:|.|.....|           |:..|:.:.|::.::   ...|:::| |......|
Mouse    72 E------GETKELWSSGHH-----------LKSCRAVVFSEDGQK---LVTVSKDK-AIHILDVE 115

  Fly   213 QLEAERRESEDINA-INGALARNIYNLVQA---------RRSKEVPRNELFAPGRMAYVIDL--- 264
            |.:.|||.|:..:| ||..|..:...||..         .:.||.|..::  .....|:.|:
Mouse   116 QGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDM--RQHEEYIADMALD 178

  Fly   265 -----------DDELGESDIPTTLKRSKFEVPVSQEDVATLTT 296
                       |..||..:|    ||.:||: :|:.....||:
Mouse   179 PAKKLLLTASGDGCLGVFNI----KRRRFEL-LSEPQSGDLTS 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beag	NP_649865.1	RED_N	87..315	CDD:285099	50/238 (21%)
beag	NP_649865.1	RED_C	434..539	CDD:285098
Wdr55	NP_080740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		4/25 (16%)
		WD 1	37..76		8/44 (18%)
		WD40	<43..338	CDD:225201	44/202 (22%)
		WD40 repeat	43..82	CDD:293791	9/44 (20%)
		WD 2	83..122		10/53 (19%)
		WD40	84..331	CDD:295369	35/155 (23%)
		WD40 repeat	89..126	CDD:293791	11/40 (28%)
		WD 3	126..164		9/37 (24%)
		WD40 repeat	131..166	CDD:293791	8/36 (22%)
		WD 4	167..206		10/43 (23%)
		WD40 repeat	173..207	CDD:293791	9/38 (24%)
		WD 5	209..248		2/8 (25%)
		WD40 repeat	214..251	CDD:293791	2/3 (67%)
		WD 6	251..290
		WD40 repeat	259..296	CDD:293791
		WD 7	293..333
		WD40 repeat	303..323	CDD:293791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1814
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030