DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and RAD7

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_012586.1	Gene:	RAD7 / 853512	SGDID:	S000003813	Length:	565	Species:	Saccharomyces cerevisiae

Alignment Length:	669	Identity:	126/669 - (18%)
Similarity:	202/669 - (30%)	Gaps:	251/669 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   764 EIAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVS 828
            |:..|:.||:|....|      ||..|::...|                     .|:.|:.:..:
Yeast    15 EVKGPNSALTQFLREE------GISAENIKQKW---------------------YQRQSKKQEDA 52

  Fly   829 VSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEM--------ESGTVSGHMTH-----WKHGM 880
            ....:|.||                 |..||:|...        |.||.||..|.     :...|
Yeast    53 TDEKKGKAE-----------------DDSFTAEISRVVEDEEIDEIGTGSGTETERAQVSYDARM 100

  Fly   881 K--RHHQLEVKTERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAE 943
            |  .....|.:.|.::..|||   :|.::......:.|:|::
Yeast   101 KLVPADSDEEEYETSHISDTP---VSLSSANDRESLTKKRQN----------------------- 139

  Fly   944 GAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSSSS 1008
                  .|.:..|:          |:|....:.|..:.:|                    ..||.
Yeast   140 ------TAKIIQNR----------RRKRKRAADLLDRRVN--------------------KVSSL 168

  Fly  1009 GNGGSASATNGISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKII 1073
            .:......:..||....::..:|....|..|.. .||:|.:| |.|...:.|:|.||:...|::
Yeast   169 QSLCITKISENISKWQKEADESSKLVFNKLRDV-LGGVSTAN-LNNLAKALSKNRALNDHTLQL- 230

  Fly  1074 FRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNC-SEHKMSASLLTAIVRRQPEHLILDWTQIAK 1137
              :|..|......|.|     :.:..|.:|.:.. |.|....||...             .|:..
Yeast   231 --FLKTDLKRLTFSDC-----SKISFDGYKTLAIFSPHLTELSLQMC-------------GQLNH 275

  Fly  1138 RQLAWLVARLPALKNLSLQ------------------------------------------NCPI 1160
            ..|.::..:||.||:|:|.                                          ||..
Yeast   276 ESLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVIMKGRLEEFHISNTHRFTDKSLSNLLINCGS 340

  Fly  1161 QAV-LAL---------------------HT-CLCPPLQTLDLSFVRGLNDAAIRDILS------- 1195
            ..| |.|                     |: |:..|....|      :||..|.::|.
Yeast   341 TLVSLGLSRLDSISNYALLPQYLVNDEFHSLCIEYPFNEED------VNDEIIINLLGQIGRTLR 399

  Fly  1196 --------PPKDSR--PGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPY---------LRH 1241
                    ...||.  .||:........|:|:.|..:|      :..|.||.|         |..
Yeast   400 KLVLNGCIDLTDSMIINGLTAFIPEKCPLEVLSLEESD------QITTDSLSYFFSKVELNNLIE 458

  Fly  1242 LDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVST 1306
            .....|.::.|..:.:: ....|...|..|||::.:.:::.|...|| |..|.:|||..|..|.
Yeast   459 CSFRRCLQLGDMAIIEL-LLNGARDSLRSLNLNSLKELTKEAFVALA-CPNLTYLDLGFVRCVD- 520

  Fly  1307 QSVIRFASNSKHDLCVRDI 1325
            .|||:.......:|.|.|:
Yeast   521 DSVIQMLGEQNPNLTVIDV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471	10/36 (28%)
		F-box-like	<1073..1108	CDD:289689	6/35 (17%)
		leucine-rich repeat	1102..1125	CDD:275381	5/23 (22%)
		leucine-rich repeat	1126..1149	CDD:275381	3/22 (14%)
		leucine-rich repeat	1150..1173	CDD:275381	11/87 (13%)
		AMN1	1166..>1320	CDD:187754	42/201 (21%)
		leucine-rich repeat	1174..1213	CDD:275381	9/55 (16%)
		leucine-rich repeat	1214..1238	CDD:275381	7/23 (30%)
		leucine-rich repeat	1239..1267	CDD:275381	4/27 (15%)
		leucine-rich repeat	1268..1292	CDD:275381	8/23 (35%)
		leucine-rich repeat	1293..1317	CDD:275381	9/23 (39%)
RAD7	NP_012586.1	AMN1	228..440	CDD:187754	40/244 (16%)
		leucine-rich repeat	236..261	CDD:275381	5/29 (17%)
		leucine-rich repeat	262..287	CDD:275381	5/37 (14%)
		leucine-rich repeat	288..340	CDD:275381	6/51 (12%)
		leucine-rich repeat	342..365	CDD:275381	3/22 (14%)
		leucine-rich repeat	368..397	CDD:275381	8/34 (24%)
		leucine-rich repeat	398..426	CDD:275381	4/27 (15%)
		leucine-rich repeat	428..455	CDD:275381	8/32 (25%)
		leucine-rich repeat	456..475	CDD:275381	3/18 (17%)
		leucine-rich repeat	484..507	CDD:275381	8/23 (35%)
		leucine-rich repeat	508..533	CDD:275381	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900