DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and AMN1

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_009716.1	Gene:	AMN1 / 852455	SGDID:	S000000362	Length:	549	Species:	Saccharomyces cerevisiae

Alignment Length:	314	Identity:	72/314 - (22%)
Similarity:	124/314 - (39%)	Gaps:	90/314 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 YSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKM------NCSEHKMSAS 1115
            :|::|.|. ||.:  :..:...|..|.:|..|.::|.| ...|.|:|.:      |..|...::.
Yeast   219 WSAAQQLR-DPPL--VGHKEKKQGALFSCMMVNRLWLN-VTRPFLFKSLHFKSVHNFKEFLRTSQ 279

  Fly  1116 LLTAIVRRQPEHLIL-DWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHTC--LCPPLQTL 1177
            ..|.::|  |.|.|| ...|:.:          |.::.||...|.....|..:.|  :.|||...
Yeast   280 ETTQVMR--PSHFILHKLHQVTQ----------PDIERLSRMECQNLKWLEFYVCPRITPPLSWF 332

  Fly  1178 DLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGT-DISDVAVRYITQSLPYLRH 1241
            |                               .|..|:.:.:.|. :|.|..:..::||:|.|:|
Yeast   333 D-------------------------------NLHKLEKLIIPGNKNIDDNFLLRLSQSIPNLKH 366

  Fly  1242 LDLSSCQRITDAGVAQIGTSTTATARLTELNLSACR---LVSENALEHLAK-----------C-- 1290
            |.|.:|..::|:||..|..:   ..:|...|:...|   |::..:|..|.|           |
Yeast   367 LVLRACDNVSDSGVVCIALN---CPKLKTFNIGRHRRGNLITSVSLVALGKYTQVETVGFAGCDV 428

  Fly  1291 -EGLIW----LDLRHVPQVSTQSV---------IRFASNSKHDLCVRDIKLVER 1330
             :..||    |:.::|.::|..|.         |.||.||..:|.|.:|:.:::
Yeast   429 DDAGIWEFARLNGKNVERLSLNSCRLLTDYSLPILFALNSFPNLAVLEIRNLDK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	10/40 (25%)
		leucine-rich repeat	1102..1125	CDD:275381	5/28 (18%)
		leucine-rich repeat	1126..1149	CDD:275381	4/23 (17%)
		leucine-rich repeat	1150..1173	CDD:275381	5/24 (21%)
		AMN1	1166..>1320	CDD:187754	41/186 (22%)
		leucine-rich repeat	1174..1213	CDD:275381	3/38 (8%)
		leucine-rich repeat	1214..1238	CDD:275381	6/24 (25%)
		leucine-rich repeat	1239..1267	CDD:275381	9/27 (33%)
		leucine-rich repeat	1268..1292	CDD:275381	8/40 (20%)
		leucine-rich repeat	1293..1317	CDD:275381	10/36 (28%)
AMN1	NP_009716.1	AMN1	285..509	CDD:187754	55/244 (23%)
		leucine-rich repeat	314..337	CDD:275381	7/53 (13%)
		leucine-rich repeat	338..363	CDD:275381	6/24 (25%)
		leucine-rich repeat	364..389	CDD:275381	9/27 (33%)
		leucine-rich repeat	390..417	CDD:275381	7/26 (27%)
		leucine-rich repeat	418..443	CDD:275381	4/24 (17%)
		leucine-rich repeat	444..471	CDD:275381	8/26 (31%)
		leucine-rich repeat	472..493	CDD:275381	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900