DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm2 and KDM2B

DIOPT Version :10

Sequence 1:NP_649864.2 Gene:Kdm2 / 41090 FlyBaseID:FBgn0037659 Length:1345 Species:Drosophila melanogaster
Sequence 2:XP_011537169.2 Gene:KDM2B / 84678 HGNCID:13610 Length:1399 Species:Homo sapiens


Alignment Length:1531 Identity:476/1531 - (31%)
Similarity:658/1531 - (42%) Gaps:502/1531 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 RKLYLEEWSLGD-EDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVAFLQQHGFNIPLLFRD 113
            |:.|.|...|.| |:....||||:.|||.|..: |...|..|.|.|....::|:....:||:||:
Human    47 RQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLY-QGDFVHAMEGKDFNYEYVQREALRVPLIFRE 110

  Fly   114 KAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSP--QKDRLLNVI 176
            |.|||::|||| :|||.||:|.||||||:|||||||||..:|:|.::.:||::|  |:|:|.|||
Human   111 KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVI 174

  Fly   177 SLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYT 241
            |||||||:|:..|:.|.:|..:||||.:||:.||:.|.|.||.:..|.||||:||||||||.|:|
Human   175 SLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFT 239

  Fly   242 DFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGN 306
            ||||||||||||||:.||.|:|||||||..||.|||:|||||||:|||.||.||:|.|:.|..|.
Human   240 DFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGY 304

  Fly   307 TFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLAR 371
            |||||:|||||||||..|||||||.||||.:..||:...:||.|:|..||||||:.||.||||.|
Human   305 TFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLER 369

  Fly   372 YVHTLLGHSHL-----------------------------------------------EGE---- 385
            ||:.:...|||                                               |||    
Human   370 YVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDR 434

  Fly   386 -------------ASLSEDE--MAARPH------------------------------------- 398
                         ::.|||:  :..:|.                                     
Human   435 APKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPA 499

  Fly   399 -------THLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAI 456
                   ||||..||.|||.:|..|..||..||.||..:.||.||::.|:::::.|..|...|||
Human   500 TEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAI 564

  Fly   457 TGVSVLKSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVG 521
            |||.|:..|                                              ..|.::..||
Human   565 TGVPVVTWP----------------------------------------------KKTPKNRAVG 583

  Fly   522 SVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAA 586
                                                             ||..|:          
Human   584 -------------------------------------------------RPKGKL---------- 589

  Fly   587 ASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNC 651
                    ||.:.|                                                   
Human   590 --------GPASAV--------------------------------------------------- 595

  Fly   652 HSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQC 716
                    ||:.|.|..| .|||||||:.|.||.|::||.|.||.||.|||||||.||:|:||||
Human   596 --------KLAANRTTAG-ARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC 651

  Fly   717 LSPMLPVTAQCVYCHLDGWRQTPVSPQTK-QLASADGPSALMECSVCYEIAHPDCALSQLDGTED 780
            ::|:||.||.|:.|...|...|....:.| .|       .|||||:|.||.||.|.        .
Human   652 IAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNL-------MLMECSICNEIIHPGCL--------K 701

  Fly   781 AADAKGIVNEDLPNSWECPSCCRSGK-----------------------------NYDYK----- 811
            ..:::|:||::|||.||||.|..:||                             |.|.|     
Human   702 IKESEGVVNDELPNCWECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEP 766

  Fly   812 ----------PR-----HFR-------ARQKSSEV-----------------RRVSVSHGQGGAE 837
                      ||     |.:       .|:||.:|                 :|.|......|:.
Human   767 AKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSS 831

  Fly   838 GHADGNTLLP-PPVGQ-----YNDFVFTSESEMESG----TVSGHMTHWKHG----------MKR 882
            .|     |.| ||:|.     :...:...:.:::.|    ........||:.          ::|
Human   832 SH-----LSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRR 891

  Fly   883 HHQ--------LEVKTERNNSCDTPSPGISPNAIGGD-----SKVGKRRK--------------- 919
            ..|        ...||..::...:.||...|:..|.:     .||..|||               
Human   892 FKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKE 956

  Fly   920 -SDDGTSVSSSMHESNDAPCGSSAEGAGGAGN--ANVSTNQWSGSGGGGGSRKKNSIRSQLAQQM 981
             :.:.....:|:...|..|..|..|..|....  ..:.......|.|..|:.::  :|.||... 
Human   957 LNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRE--LRHQLGPS- 1018

  Fly   982 LNSSTRVLKKP-------------QYVVRPASGTGSSSSSGNGGSASATNGISNGSNQSGANSCG 1033
            |.|..||:.:|             ::|:||...:....|                          
Human  1019 LRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDS-------------------------- 1057

  Fly  1034 AGNGERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVD 1098
                        |...:|..:         .:...|...:|.||....|..|..||:.|:....|
Human  1058 ------------LPLDDGAAH---------VMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCD 1101

  Fly  1099 PDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQA 1162
            ..||.:::.:..| ::..:|:.|:||||..|.|.||.|:|:||:||:.|||.|::|.|..|...|
Human  1102 KRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIA 1166

  Fly  1163 VLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDV 1227
            |.||.:..||.|:|||:.:|.||.||.:||:||||.|:|||..|::::||::..::|||.||:|.
Human  1167 VSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA 1231

  Fly  1228 AVRYITQSLPYLRHLDLSSCQRITDAGV---AQIGTSTTATARLTELNLSACRLVSENALEHLAK 1289
            ::|.|.:.:|.|..|.||.|..:||..:   ..:||:|..:  |||:|||.|..|::..|....:
Human  1232 SLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS--LTEINLSDCNKVTDQCLSFFKR 1294

  Fly  1290 CEGLIWLDLRHVPQVSTQSVIRFASNSKHDLCVRDI 1325
            |..:..:|||:..||:.:...:|.:....:..::.|
Human  1295 CGNICHIDLRYCKQVTKEGCEQFIAEMSDEESIQKI 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm2NP_649864.2 cupin_RmlC-like 231..331 CDD:477354 76/99 (77%)
CTD_Jhd1-like 399..465 CDD:412024 31/65 (48%)
zf-CXXC 670..716 CDD:366873 30/45 (67%)
PHD_4 721..802 CDD:465288 31/81 (38%)
F-box-like <1073..1105 CDD:463757 11/31 (35%)
leucine-rich repeat 1102..1125 CDD:275381 6/23 (26%)
leucine-rich repeat 1126..1149 CDD:275381 12/22 (55%)
leucine-rich repeat 1150..1173 CDD:275381 9/22 (41%)
AMN1 1166..>1320 CDD:187754 60/156 (38%)
leucine-rich repeat 1174..1213 CDD:275381 21/38 (55%)
leucine-rich repeat 1214..1238 CDD:275381 8/23 (35%)
leucine-rich repeat 1239..1267 CDD:275381 10/30 (33%)
leucine-rich repeat 1268..1292 CDD:275381 10/23 (43%)
leucine-rich repeat 1293..1317 CDD:275381 6/23 (26%)
KDM2BXP_011537169.2 JmjC 182..257 CDD:214721 45/74 (61%)
cupin_RmlC-like 229..335 CDD:477354 81/105 (77%)
JHD 334..>369 CDD:465515 18/34 (53%)
CTD_KDM2B 507..573 CDD:412026 31/65 (48%)
zf-CXXC <615..651 CDD:366873 23/35 (66%)
PHD_KDM2B 661..722 CDD:277114 27/75 (36%)
PTZ00449 <720..1022 CDD:185628 52/309 (17%)
F-box_FBXL10 1063..1107 CDD:438951 13/52 (25%)
leucine-rich repeat 1105..1129 CDD:275381 6/23 (26%)
AMN1 1121..1310 CDD:187754 84/190 (44%)
leucine-rich repeat 1130..1153 CDD:275381 12/22 (55%)
leucine-rich repeat 1154..1177 CDD:275381 9/22 (41%)
leucine-rich repeat 1178..1217 CDD:275381 21/38 (55%)
leucine-rich repeat 1218..1242 CDD:275381 8/23 (35%)
leucine-rich repeat 1243..1272 CDD:275381 10/28 (36%)
leucine-rich repeat 1273..1297 CDD:275381 10/23 (43%)
leucine-rich repeat 1298..1323 CDD:275381 6/24 (25%)

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