DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and KDM7A

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_085150.1	Gene:	KDM7A / 80853	HGNCID:	22224	Length:	941	Species:	Homo sapiens

Alignment Length:	1045	Identity:	255/1045 - (24%)
Similarity:	400/1045 - (38%)	Gaps:	355/1045 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PNAKGVQRRQLRERKQRKLYLEEWSLGD----EDGE-----GTRGFSVAEKLESSKFAQAG-MVR 88
            ||...:....|.::::      .|...|    :||.     |||.|  .::|.|..|..|. ::.
Human    83 PNCAVLHGSSLMKKRR------NWHRHDYTEIDDGSKPVQAGTRTF--IKELRSRVFPSADEIII 139

  Fly    89 EMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNL 153
            :|.|..||..:|::|||::|::......||||:|.| .|:|.||...||..:::||:||..|.:.
Human   140 KMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSP-TFSVMDVERYVGGDKVIDVIDVARQADS 203

  Fly   154 QMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTN 218
            :||:..:.:|:.:|.:.::|||||||||.|::...|:.|:|.:::.||:..||..
Human   204 KMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDD---------- 258

  Fly   219 LLGGMMYPK--VQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVL 281
                .::||  |||||||.|::.||||||||||||||||:|.|.|:|:||.|||.||..||.|..
Human   259 ----SVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSS 319

  Fly   282 SGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASV 346
            |..|:::||||.|:||.:..:..|:|.|:||||||||.|....:.|||||||:..|..||:...:
Human   320 SVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEM 384

  Fly   347 EDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHL--------TH 403
            |...|.|..|::|||..:.|:|....:.||         ..|.||  ..:|.|:|        |.
Human   385 EKRLKTPDLFKFPFFEAICWFVAKNLLETL---------KELRED--GFQPQTYLVQGVKALHTA 438

  Fly   404 HELFGLKEIVM-YLYDLP-------------------------PQK-KNVPSLVLDPVALI---- 437
            .:|:..||:|. :.:::|                         |.| :.:|  ::.||:..
Human   439 LKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIP--IVCPVSRSSNEA 501

  Fly   438 -------KDVRSLVERHCKDQQDLAITGV---SVLK------------------------SPPGS 468
                   :.:|.|.:.:.:...:|.|..:   .|||                        .|..:
Human   502 TSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILSSKLNGKFNKHLQPSST 566

  Fly   469 QPPF--------LLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIG 525
            .|.:        ||....|:.::.:|..|.::......:.:.:..|.::|:....:|:||
Human   567 VPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESSGV----- 626

  Fly   526 MGAGVEYS------NGV---MKKEQLENGSGVT--VGGHGSQPEATFALPTDTLKYRPPKKMHLA 579
              .|||:.      ||.   :|.|.....||.:  .....|.||.|                  |
Human   627 --EGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESEDSGPECT------------------A 671

  Fly   580 TALVAAAASSSSGGGGPVAGVGGS---------AVVGSSHSPTGGGVGPVTGAGGAISVIATSSS 635
            ...:.....|.|.|......:..:         ..:..|..|:...:        .|.....:|:
Human   672 LKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEI--------PIKRECPTST 728

  Fly   636 YIEGGQVGGILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVK 700
            ..|...:.|:|:|...|
Human   729 STEEEAIQGMLSMAGLH------------------------------------------------ 745

  Fly   701 FGGPGRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSP--------QTKQLASADGPSALM 757
                   ..||:.||..|      ..|     .|.|.:...|        :.:||...|.|   :
Human   746 -------YSTCLQRQIQS------TDC-----SGERNSLQDPSSCHGSNHEVRQLYRYDKP---V 789

  Fly   758 ECSVCYEIAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYD---YKPRHFRARQ 819
            ||....:...||...|                     ||.        |.:|   :.|:.....|
Human   790 ECGYHVKTEDPDLRTS---------------------SWI--------KQFDTSRFHPQDLSRSQ 825

  Fly   820 K------SSEV-RRVSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWK 877
            |      |||: :||                        |..::|.:|.|.:::|
Human   826 KCIRKEGSSEISQRV------------------------QSRNYVDSSGSSLQNG---------- 856

  Fly   878 HGMKRHHQLEVKTERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMH-----ESNDAP 937
                       |..:|::..:.:..||..::..:..||:       ||.|..:|     .||..|
Human   857 -----------KYMQNSNLTSGACQISNGSLSPERPVGE-------TSFSVPLHPTKRPASNPPP 903

  Fly   938 CGSSA 942
            ..:.|
Human   904 ISNQA 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	59/99 (60%)
		PRTases_typeI	<394..>467	CDD:294217	22/145 (15%)
		zf-CXXC	670..716	CDD:251032	3/45 (7%)
		PHD_4	721..801	CDD:293471	15/87 (17%)
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
KDM7A	NP_085150.1	PHD_KDM7	39..88	CDD:277110	2/4 (50%)
		Linker	97..114		4/22 (18%)
		JmjC	234..297	CDD:214721	34/76 (45%)
		cupin_like	269..369	CDD:304367	59/99 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..633		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..700		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..921		26/142 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810