DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and lrrc29

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_001339819.4	Gene:	lrrc29 / 799466	ZFINID:	ZDB-GENE-030131-7165	Length:	644	Species:	Danio rerio

Alignment Length:	326	Identity:	76/326 - (23%)
Similarity:	130/326 - (39%)	Gaps:	63/326 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 QNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSASLLTAIVRRQP 1125
            ::|.|...::..||.:|..........|||.|.||:.|....:.:.......|:||  ..:|...
Zfish     2 ESLHLPSEIITYIFSFLHVMDRKEASLVCKSWYNASQDYPFKRNLTFKFPASSSSL--GFIRGLA 64

  Fly  1126 EH----LI---LDWTQIAKRQLAWLVARL-PALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFV 1182
            .|    |:   ||.:.::::.|..:...| |.|.:|:|....|.....|.  |.|.|.:|....:
Zfish    65 RHPRCGLVISHLDGSSVSRQVLLEVGLHLGPRLDSLALPGSSITESCLLE--LLPRLTSLRKLDL 127

  Fly  1183 RGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSC 1247
            :||:...:.......::.|..:..:...|.:|.:..|  ..:||::...:|...|.||.|.||.|
Zfish   128 QGLDSLFMSGAFLSREEHRRKVYRALLNLEELNLSNL--RYLSDLSFNRLTICTPGLRRLSLSGC 190

  Fly  1248 Q--------RITDAG--------------VAQIGTSTTAT---------------------ARLT 1269
            .        |....|              :.|..|||..:                     .||.
Zfish   191 HISFEFDPYRGCPVGSGSSALVSLRNLLNLLQKQTSTLRSLDLSRTGITPKSLRSISKLRGLRLE 255

  Fly  1270 ELNLSACRLVSENALEHLAKCE-GLIWLDLRHVPQVSTQSVIRFASNSKHDLCV----RDIKLVE 1329
            ||||..|:.:::.::|.|.|.: ||..|||....::|.::|:...:..| :|.|    :|.|:.:
Zfish   256 ELNLHGCKELTDYSIEILCKYQSGLRMLDLSGCMELSCRAVLAVGAELK-ELRVLSFSQDWKITD 319

  Fly  1330 R 1330
            :
Zfish   320 K 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	10/34 (29%)
		leucine-rich repeat	1102..1125	CDD:275381	4/22 (18%)
		leucine-rich repeat	1126..1149	CDD:275381	6/30 (20%)
		leucine-rich repeat	1150..1173	CDD:275381	6/22 (27%)
		AMN1	1166..>1320	CDD:187754	45/197 (23%)
		leucine-rich repeat	1174..1213	CDD:275381	6/38 (16%)
		leucine-rich repeat	1214..1238	CDD:275381	5/23 (22%)
		leucine-rich repeat	1239..1267	CDD:275381	12/70 (17%)
		leucine-rich repeat	1268..1292	CDD:275381	9/24 (38%)
		leucine-rich repeat	1293..1317	CDD:275381	6/23 (26%)
lrrc29	XP_001339819.4	F-box-like	4..49	CDD:289689	12/44 (27%)
		leucine-rich repeat	71..96	CDD:275381	5/24 (21%)
		leucine-rich repeat	97..121	CDD:275381	8/25 (32%)
		leucine-rich repeat	122..179	CDD:275381	10/58 (17%)
		leucine-rich repeat	182..227	CDD:275381	10/44 (23%)
		AMN1	215..427	CDD:187754	26/107 (24%)
		leucine-rich repeat	228..253	CDD:275381	0/24 (0%)
		leucine-rich repeat	254..277	CDD:275381	9/22 (41%)
		leucine-rich repeat	280..305	CDD:275381	7/25 (28%)
		leucine-rich repeat	306..325	CDD:275381	4/15 (27%)
		leucine-rich repeat	331..359	CDD:275381
		leucine-rich repeat	360..386	CDD:275381
		leucine-rich repeat	387..412	CDD:275381
		leucine-rich repeat	413..497	CDD:275381
		AMN1	<498..613	CDD:187754
		leucine-rich repeat	498..522	CDD:275381
		leucine-rich repeat	523..548	CDD:275381
		leucine-rich repeat	549..574	CDD:275381
		leucine-rich repeat	575..598	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900