DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and kdm2ab

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_001339797.3	Gene:	kdm2ab / 799441	ZFINID:	ZDB-GENE-101007-5	Length:	1263	Species:	Danio rerio

Alignment Length:	1489	Identity:	475/1489 - (31%)
Similarity:	667/1489 - (44%)	Gaps:	425/1489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVAFL 100
            ||....::||...:|: |.:: .:.|::.||.|.|.:.|||:|.:: .:.:|:.|.|.|.|:.::
Zfish     4 AKSRYSKRLRSGTRRR-YQDD-GISDDEIEGKRSFDLEEKLQSDRY-NSNLVKIMDGKDFTLEYI 65

  Fly   101 QQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYD 165
            |:.|...|::|:...|||::|||| :|:|:||:|.|||||::||||..|||.::|:|.:|::||:
Zfish    66 QREGLRDPIIFKKADGLGIKMPDP-DFSVSDVKLFVGSRRMIDVMDAATQKGIEMSMGQWRRYYE 129

  Fly   166 SP--QKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKV 228
            :|  |:::|.||||||||||:|:..|:.|..|..|||||.:||:.||:.||:.||.:..|.||||
Zfish   130 TPASQREKLYNVISLEFSHTKLEHLVKRPTSVDMIDWVDNMWPRHLKERQRDSTNAITDMQYPKV 194

  Fly   229 QKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDT 293
            ||||||||:.|:||||||||||||||||.:|.|||||||||.:||:|||.||||.||.|||.||.
Zfish   195 QKYCLMSVEGCFTDFHIDFGGTSVWYHIHKGGKVFWLIPPTPQNLELYENWVLSAKQGDIFLGDK 259

  Fly   294 VEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRY 358
            ...|.|:.|..|.||.||:|||||||||..:|||||||||||.|..||...::||.|:||.||||
Zfish   260 ASMCQRIELKQGYTFMIPSGWIHAVYTPMDTLVFGGNFLHSFNIPMQLNIFNIEDRTRVPSKFRY 324

  Fly   359 PFFTEMLWYVLARYVHTLLGHSHLEGE-----------------------ASLSEDEMA------ 394
            ||:.||.||||.||::.|...|||..|                       .|.||||..
Zfish   325 PFYFEMCWYVLERYLYCLTNTSHLTPEFQKHSLGIGLKKEDVIKPAKPDGDSESEDEEVKEEPEE 389

  Fly   395 ------ARP--HTHLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQ 451
                  |||  ..||...||.||..::..|.|||..||.||:.:.:..||:.|:|.|:|.|..|.
Zfish   390 EAVTPPARPGVKVHLAPFELEGLWALLHKLEDLPAHKKCVPAGIRNAPALLSDIRKLLEEHANDN 454

  Fly   452 QDLAITGVSVL---KSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESD 513
            ..|:.||..::   |.|...|||
Zfish   455 PKLSYTGKPIVKWPKRPSWYQPP------------------------------------------ 477

  Fly   514 TSQSTGVGSVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHL 578
                                                                     .||...||
Zfish   478 ---------------------------------------------------------PPPPPSHL 485

  Fly   579 ATALVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVG 643
                                           :.|...|.||:.
Zfish   486 -------------------------------YRPRTPGSGPML---------------------- 497

  Fly   644 GILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAK 708
                     :|.....|.|.:::..   ||||.|||.|.||.|::||.|.:|.||.|||||||.|
Zfish   498 ---------APVPRPVKPSSSISAL---RRRRVRCKRCEACLRTECGNCNYCRDMRKFGGPGRLK 550

  Fly   709 QTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALS 773
            ::|::||||:|.||:||.||.|. :|.::   |..|:.:      ..|||||.|.:|.||:|.
Zfish   551 KSCVLRQCLAPALPLTAVCVICK-EGNQE---SDDTESV------QMLMECSECAQITHPECI-- 603

  Fly   774 QLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHG------ 832
                   ....:|::|:|||:.||||.|.:..|.        .:...|.|....|||:.
Zfish   604 -------KVPGEGVINKDLPSCWECPKCVQGKKT--------ESSSSSEEETDSSVSNSSRLSGP 653

  Fly   833 -------QG-GAEG---HADGNTLLPP---PVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRH 883
                   :| |.||   ...|.:.:.|   |:         :.|..:.......:...:...||.
Zfish   654 PAKRAYREGIGVEGLRIARRGRSSISPSSLPI---------TRSRRQPPPSQRLLLQHQQNRKRA 709

  Fly   884 HQLE------VKTERNNSC-DTPSP-GISPNAIGGDSKVGKRR---KSDDGTSVSSSMHESNDAP 937
            ..||      :|.|||... .|.|| .:||..:...|.  :||   ::..|.|:|.....|:...
Zfish   710 GALELQLRKRIKLERNKILQSTRSPVSLSPKLLRQRSL--ERRGLIRAGPGQSLSRGRGSSSFRG 772

  Fly   938 CGSSAEGAGGAG-----------------------------------------------NANVST 955
            .|....|.|..|                                               |.:...
Zfish   773 RGLRVRGGGRGGGLRERMEMVVEREDSAEEEQQERKENGQYNGKENRPQRLSGKAGEDENGDAHR 837

  Fly   956 NQWSGSGGGGG----------------------------SRKKNSIRSQLAQQMLNSSTRVLKKP 992
            |..|.....||                            ||.|....:.:.:...|.|:|.| .|
Zfish   838 NGESEESSEGGEPTLSDTSVALTDDVRGQESCVTVKLQPSRAKRDPSTIVPKLEANLSSRSL-PP 901

  Fly   993 QY--VVRPASGTGSSSSSG----------------NGGSASATNGISNGSN-------------- 1025
            .:  ::||....|:..|..                :..|.:.|...|..||
Zfish   902 NHKALLRPPLRNGARCSDAPHSPGDRLHVNKSHALSSSSHTLTRRASKNSNLRSNFEDSTHRLTR 966

  Fly  1026 ---QSGANSCGAGNGERGTNNGGLSGS---NGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVT 1084
               |..|.|      ||..::.....|   :|.||:.       ..:..|...:||||.:..|..
Zfish   967 ERIQKNARS------ERAKSSDSCPSSTFHSGGGNEP-------GWEKEVWVSVFRYLTRAELCV 1018

  Fly  1085 CCSVCKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLP 1148
            |.:|||.|.....|..||.:::.|..: ||..:||.|::|||..|.|.|..|.|:||:||:.|||
Zfish  1019 CMAVCKSWYKWGCDKRLWTRISLSRSRSMSPQVLTGIIKRQPVTLDLSWANITKKQLSWLINRLP 1083

  Fly  1149 ALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRD 1213
            .||:|.|..|...:|.||.:..||.|::||||:..|:.||.||::|:||.      ||:::::::
Zfish  1084 GLKDLVLSGCNWSSVSALSSPSCPLLRSLDLSWADGIKDAQIRELLNPPG------SDNRSQMKN 1142

  Fly  1214 LKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAG---VAQIGTSTTATARLTELNLSA 1275
            ::.:.|.|.::::..:|.|.:.:|.|..|:||.|. |||..   ::.:|:||..|  ||.|||:.
Zfish  1143 MQCLWLCGLEVTEATLRLIIRHMPLLTRLELSRCP-ITDGALNLLSAVGSSTRNT--LTHLNLAG 1204

  Fly  1276 CRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFAS----NSKHDLCVRDIKLVER 1330
            |..:::..|.:|.:...|..||||....||.|:...|.|    |:.:.|  .|.||:||
Zfish  1205 CTQLTDRCLVYLRRLSCLSILDLRDCKGVSVQACQSFISELSVNTLYYL--SDDKLIER 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	71/99 (72%)
		PRTases_typeI	<394..>467	CDD:294217	30/89 (34%)
		zf-CXXC	670..716	CDD:251032	27/45 (60%)
		PHD_4	721..801	CDD:293471	29/79 (37%)
		F-box-like	<1073..1108	CDD:289689	13/34 (38%)
		leucine-rich repeat	1102..1125	CDD:275381	8/23 (35%)
		leucine-rich repeat	1126..1149	CDD:275381	11/22 (50%)
		leucine-rich repeat	1150..1173	CDD:275381	9/22 (41%)
		AMN1	1166..>1320	CDD:187754	54/160 (34%)
		leucine-rich repeat	1174..1213	CDD:275381	15/38 (39%)
		leucine-rich repeat	1214..1238	CDD:275381	4/23 (17%)
		leucine-rich repeat	1239..1267	CDD:275381	12/30 (40%)
		leucine-rich repeat	1268..1292	CDD:275381	8/23 (35%)
		leucine-rich repeat	1293..1317	CDD:275381	11/27 (41%)
kdm2ab	XP_001339797.3	JmjC	150..221	CDD:214721	44/70 (63%)
		cupin_like	197..297	CDD:304367	71/99 (72%)
		zf-CXXC	<524..558	CDD:251032	19/33 (58%)
		PHD_4	563..624	CDD:293471	29/79 (37%)
		F-box-like	1002..1042	CDD:289689	14/39 (36%)
		leucine-rich repeat	1036..1060	CDD:275381	8/23 (35%)
		leucine-rich repeat	1061..1084	CDD:275381	11/22 (50%)
		AMN1	1075..1230	CDD:187754	61/163 (37%)
		leucine-rich repeat	1085..1108	CDD:275381	9/22 (41%)
		leucine-rich repeat	1109..1142	CDD:275381	15/38 (39%)
		leucine-rich repeat	1143..1167	CDD:275381	4/23 (17%)
		leucine-rich repeat	1197..1216	CDD:275381	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2068
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56564
Inparanoid	1	1.050	794	1.000	Inparanoid score	I491
OMA	1	1.010	-	-		QHG50015
OrthoDB	1	1.010	-	-		D165446at33208
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104082
Panther	1	1.100	-	-	LDO	PTHR23123
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R626
SonicParanoid	1	1.000	-	-		X1005
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870