DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and fbxl17

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_001335097.5	Gene:	fbxl17 / 795023	ZFINID:	ZDB-GENE-111013-3	Length:	409	Species:	Danio rerio

Alignment Length:	269	Identity:	62/269 - (23%)
Similarity:	105/269 - (39%)	Gaps:	44/269 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1005 SSSSGNGGSASATNGISNG--SNQSGANSCG---------AGNGERGTNNGGLSGSNGLGNQHYS 1058
            ||||.:..|||..:|.:.|  |:..||.:|.         |....:.|.|...|..|
Zfish   166 SSSSSSSSSASEEDGATAGRHSDPGGATTCSSSSCCCQTEASEEIKSTENTDTSHIN-------- 222

  Fly  1059 SSQNLALDPTVLKIIFRYLP-QDTLVTCCSVCKVWSNAAVDPDLWKKMNCSE-HKMSASLLTAIV 1121
                 .|..::|..:|.:|. ::..:....|||.|.:..:|...||:::.|. .::...||..|.
Zfish   223 -----QLPSSILLKVFSHLSVKERCLAASLVCKYWRDLCLDFQFWKQIDLSGLQQVKDDLLVKIA 282

  Fly  1122 -RRQ--PEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHTCL--CPPLQTLDLSF 1181
             |||  .|..|.|...:....:..|.:....|...:...|...:.::|.|..  ||.||.:.:..
Zfish   283 SRRQNVTEINISDCRNVQDHGVCALASNCAGLIKYTAYRCKQLSDVSLSTVAIHCPLLQKVHVGN 347

  Fly  1182 VRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSS 1246
            ...|.|.|::           .|.|....|:|:...:.  ..|||..:..:.|....|:.:.:..
Zfish   348 QDKLTDHALK-----------LLGDHCKELKDVHFGQC--YSISDEGLMSLAQGCNKLQRIYMQE 399

  Fly  1247 CQRITDAGV 1255
            .:.::.||:
Zfish   400 NKLVSQAGI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	9/35 (26%)
		leucine-rich repeat	1102..1125	CDD:275381	9/26 (35%)
		leucine-rich repeat	1126..1149	CDD:275381	4/22 (18%)
		leucine-rich repeat	1150..1173	CDD:275381	5/24 (21%)
		AMN1	1166..>1320	CDD:187754	20/92 (22%)
		leucine-rich repeat	1174..1213	CDD:275381	8/38 (21%)
		leucine-rich repeat	1214..1238	CDD:275381	4/23 (17%)
		leucine-rich repeat	1239..1267	CDD:275381	3/17 (18%)
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
fbxl17	XP_001335097.5	F-box-like	221..268	CDD:289689	12/59 (20%)
		AMN1	257..>397	CDD:187754	34/152 (22%)
		leucine-rich repeat	262..287	CDD:275381	8/24 (33%)
		leucine-rich repeat	288..313	CDD:275381	4/24 (17%)
		leucine-rich repeat	314..339	CDD:275381	5/24 (21%)
		leucine-rich repeat	340..365	CDD:275381	7/35 (20%)
		leucine-rich repeat	366..391	CDD:275381	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810