Protein Alignment Kdm2 and kdm7a

DIOPT Version :10

• Sequence 1: NP_649864.2
• Gene: Kdm2 / 41090
• FlyBaseID: FBgn0037659
• Length: 1345
• Species: Drosophila melanogaster
• Sequence 2: NP_001072664.1
• Gene: kdm7a / 780121
• XenbaseID: XB-GENE-5900920
• Length: 922
• Species: Xenopus tropicalis
• Alignment Length: 1041
• Identity: 255/1041 - (24%)
• Similarity: 386/1041 - (37%)
• Gaps: 354/1041 - (34%)

  Fly    43 QLRERK--QRKLYLEEWSLGDEDG-----EGTRGFSVAEKLESSKFAQA-GMVREMRGCDLTVAF 99
            ||::|:  .|..|.|     .:||     .|||.|  .::|::..|..| .::.:|.|..||..:
 Frog    62 QLKKRRNWHRHDYTE-----PDDGTKPVQAGTRTF--IQQLQARSFPSADDLLLKMNGSQLTQRY 119

  Fly   100 LQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYY 164
            |::.|||:|::......||||:| |..|:|.||...||..:::||:||..|.:.:|.:|.:.:|:
 Frog   120 LEKQGFNLPIMVPRLDDLGLRLP-PPTFSVMDVERYVGGEKIIDVIDVARQADSKMKLKNFVKYF 183

  Fly   165 DSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQ 229
            .:|.:.::|||||||||.|::...|:.|:|.:::.||:..||..            .....|.||
 Frog   184 MNPDRPKVLNVISLEFSDTKMADLVKVPDISKKLSWVENYWPDD------------SFFTKPFVQ 236

  Fly   230 KYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTV 294
            |||||.|::.||||||||||||||||:|.|.|||:||.|:|.||.|||.|..|..|::.||||.|
 Frog   237 KYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPSDENLALYESWSSSVTQSEEFFGDKV 301

  Fly   295 EKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYP 359
            :||.:..:..|:|.|:||||||||.|....:.|||||||:..|..||:...:|...|.|..|::|
 Frog   302 DKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFP 366

  Fly   360 FFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHLTHHELFGLKEIVMYL-------- 416
            ||..:.|:|....:.||         ..|.||  ...|..:|.|    |:|.::..|
 Frog   367 FFEAICWFVAKNLLETL---------KELKED--GFHPPNYLKH----GVKALISALKSWMKKES 416

  Fly   417 -----YDLPPQKKNVPSLVLDPVALIKD----VRSLVER------------HC------------ 448
                 :::|..        :.|..|||:    :||:.|.            ||
 Frog   417 VAEHAFEIPDN--------IRPGHLIKELSKVIRSVEEEGNRPVKSQGIHGHCPVSRSSHEKSSH 473

  Fly   449 ---------KDQQDLAITGVSVLK------------SP----PG--------SQPPFLLYDRTRV 480
                     :|......|.:.:|:            ||    .|        ::|  ||...|..
 Frog   474 HSGRKARRLRDHSTKTPTNLDILEHHTREVLKRLEMSPWEEDAGTYKLNMRFNKP--LLPSSTEP 536

  Fly   481 KQEIKQEIAR---KNAEVIREQQQLEAGRA-----REAESDTSQSTGVGSVIGMGAGVEYSNGVM 537
            .|:::....|   .|..:||:::|....|:     .|.|.|.::|.....:
 Frog   537 DQKVRDNGIRLLLSNGRIIRDERQPFTDRSLYTADSEDEDDRARSRKAKDI-------------- 587

  Fly   538 KKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGGPVAGVGG 602
            |:|:..:.||:                .|..:.:.|..|     ...:..|....|....:.:..
 Frog   588 KQEKPCSTSGM----------------EDKAETQKPLNM-----FFESVKSELRNGSSEYSDISD 631

  Fly   603 SAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGG----------------ILNMDNC 651
            |.  ||..:.|                  ....:.|..:..|                |.|:...
 Frog   632 SE--GSEDNCT------------------NQKHFSEESESSGDDDDEEEEEEEERQEPIRNLKEE 676

  Fly   652 HSPEGGGAKL--SPNL--TGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCM 712
            ||    |.:|  .||.  .....|::|.                ||              ..|.|
 Frog   677 HS----GRRLPCDPNFPWPDHDSPQKRE----------------CP--------------TSTSM 707

  Fly   713 MRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDG 777
            .::.:..||                        .:||...|||
 Frog   708 EQEAVQGML------------------------SMASLHYPSA---------------------- 726

  Fly   778 TEDAADAKGIVNEDLPNSWECPSC-CRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHA- 840
                          ||...:...| .|.|    |...|.|..|.:.:....|.||....::.|.
 Frog   727 --------------LPTPAKSTDCNIRGG----YPQLHIRVSQGNGKEHLDSHSHKAANSDHHVK 773

  Fly   841 --------------DGNTLLPP------PVGQYNDFVFTSESEMESGTVSGH---MTHWKHGMKR 882
                          |.:..|.|      |.....:|   :..|.|......|   :.||.....:
 Frog   774 DEGEFSALDWIRQPDASCRLSPQDSCQVPQSLRREF---AHEEYEKAPEDKHYLEIEHWDSAEYQ 835

  Fly   883 HHQLEVKTERNN-SCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMH-----ESNDAPCGSS 941
            ..:.:.::..:: .|......:||..|.||            |:.:..:|     .||..|..:.
 Frog   836 PEKYDPESSMSSGECHLSDGSLSPTRIYGD------------TAAAVPLHPTKRPASNPPPISNQ 888

  Fly   942 A 942
            |
 Frog   889 A 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_649864.2	cupin_RmlC-like	231..331	CDD:477354	60/99 (61%)
		CTD_Jhd1-like	399..465	CDD:412024	18/127 (14%)
		zf-CXXC	670..716	CDD:366873	6/45 (13%)
		PHD_4	721..802	CDD:465288	9/81 (11%)
		F-box-like	<1073..1105	CDD:463757
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
kdm7a	NP_001072664.1	PHD_KDM7	8..57	CDD:277110
		JmjC	203..266	CDD:214721	33/74 (45%)
		cupin_RmlC-like	238..338	CDD:477354	60/99 (61%)
		JHD	342..445	CDD:465515	30/125 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..490		4/44 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..607		10/71 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..711		21/142 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..773		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..902		5/18 (28%)