DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and FBXL17

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_005272105.1	Gene:	FBXL17 / 64839	HGNCID:	13615	Length:	712	Species:	Homo sapiens

Alignment Length:	746	Identity:	153/746 - (20%)
Similarity:	232/746 - (31%)	Gaps:	245/746 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 QPRRRRTRCKNCAACQR------------------------SDC---GTCPFCMDMVKFGGPGRA 707
            :|.::|.||  |:.|:|                        .||   |.|..|..:...|.|
Human    12 RPSQKRPRC--CSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCMLCFIVHSPGAP--- 71

  Fly   708 KQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCA- 771
                      :|..|.            .:.|:||..:..|.|...|:.........:|..|||
Human    72 ----------APAGPE------------EEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAA 114

  Fly   772 ------LSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVS 830
                  ||..     ||.|....:...|     .|||                      :.:.::
Human   115 AARRFLLSSA-----AAAAAAAASASSP-----ASCC----------------------KELGLA 147

  Fly   831 HGQGGAEGHADGNTL----------LPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQ 885
               ..|.....|.:|          |.||..
Human   148 ---AAAAWEQQGRSLFLASLGPVRFLGPPAA---------------------------------- 175

  Fly   886 LEVKTERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAEGAGGAGN 950
              |:..|.   .||||...|..   ...|.||:    |..|.:.      .||.....|.||.|.
Human   176 --VQLFRG---PTPSPAELPTP---PEMVCKRK----GAGVPAC------TPCKQPRCGGGGCGG 222

  Fly   951 ANVSTNQWSGSGGGGG--------SRKKNSIRSQLAQQMLNSSTRVLKKPQYVV-RPASGTGSSS 1006
            .       .|.|||||        .|..::...|..:|          .||.:. .|:|.|...:
Human   223 G-------GGGGGGGGPAGGGASPPRPPDAGCCQAPEQ----------PPQPLCPPPSSPTSEGA 270

  Fly  1007 SSGNGGSASATNGISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNL----ALDP 1067
            .:..||.|....|.:..|.|. .:.||..:......|.        .:.|.......    .|.|
Human   271 PTEAGGDAVRAGGTAPLSAQQ-QHECGDADCRESPENP--------CDCHREPPPETPDINQLPP 326

  Fly  1068 TVLKIIFRYLPQDTLVTCCS---VCKVWSNAAVDPDLWKKMN-CSEHKMSASLLTAIVRRQP--- 1125
            ::|..||..|..|.  .|.|   |||.|.:..:|...||::: .|..:::..||..|..|..
Human   327 SILLKIFSNLSLDE--RCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNII 389

  Fly  1126 EHLILDWTQIAKRQLAWLVARLPALKNLSLQNC------PIQAVLALHTCLCPPLQTLDLSFVRG 1184
            |..|.|...::...:..|..:.|.|...:...|      .|.|| |.|   ||.||.:.:.....
Human   390 EINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAV-ASH---CPLLQKVHVGNQDK 450

  Fly  1185 LNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGT-DISDVAVRYITQSLPYLRHLDLSSCQ 1248
            |.|              .||....::.|:||.:..... .|||..:..|.:....|:.:.:...:
Human   451 LTD--------------EGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENK 501

  Fly  1249 RITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFA 1313
            .:||..|......   ...|..:....|.:.|:..: ||.|...|..|||||:.::..::|:...
Human   502 LVTDQSVKAFAEH---CPELQYVGFMGCSVTSKGVI-HLTKLRNLSSLDLRHITELDNETVMEIV 562

  Fly  1314 SNSKH----DLCV------RDIKLVERRRRN 1334
            ...|:    :||:      |.::::.:..:|
Human   563 KRCKNLSSLNLCLNWIINDRCVEVIAKEGQN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032	14/72 (19%)
		PHD_4	721..801	CDD:293471	17/86 (20%)
		F-box-like	<1073..1108	CDD:289689	13/38 (34%)
		leucine-rich repeat	1102..1125	CDD:275381	7/23 (30%)
		leucine-rich repeat	1126..1149	CDD:275381	4/22 (18%)
		leucine-rich repeat	1150..1173	CDD:275381	8/28 (29%)
		AMN1	1166..>1320	CDD:187754	34/158 (22%)
		leucine-rich repeat	1174..1213	CDD:275381	6/38 (16%)
		leucine-rich repeat	1214..1238	CDD:275381	6/24 (25%)
		leucine-rich repeat	1239..1267	CDD:275381	4/27 (15%)
		leucine-rich repeat	1268..1292	CDD:275381	6/23 (26%)
		leucine-rich repeat	1293..1317	CDD:275381	7/23 (30%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	16/48 (33%)
		leucine-rich repeat	362..387	CDD:275381	7/24 (29%)
		leucine-rich repeat	388..413	CDD:275381	4/24 (17%)
		AMN1	411..573	CDD:187754	41/183 (22%)
		leucine-rich repeat	414..439	CDD:275381	8/28 (29%)
		leucine-rich repeat	440..465	CDD:275381	6/38 (16%)
		leucine-rich repeat	466..491	CDD:275381	6/24 (25%)
		leucine-rich repeat	492..517	CDD:275381	4/27 (15%)
		leucine-rich repeat	518..541	CDD:275381	6/23 (26%)
		leucine-rich repeat	542..567	CDD:275381	7/24 (29%)
		AMN1	547..>652	CDD:187754	9/47 (19%)
		leucine-rich repeat	568..593	CDD:275381	3/24 (13%)
		leucine-rich repeat	594..615	CDD:275381	153/746 (21%)
		leucine-rich repeat	619..641	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810