DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and kdm2aa

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_005160305.1	Gene:	kdm2aa / 571851	ZFINID:	ZDB-GENE-061215-144	Length:	1318	Species:	Danio rerio

Alignment Length:	1544	Identity:	481/1544 - (31%)
Similarity:	665/1544 - (43%)	Gaps:	496/1544 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VQRRQLRERKQ--------------RKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVRE 89
            :.||:.|:||.              |:.|.:: .:.|::.:|.|.|.:.|||.|| |..:..|:.
Zfish    17 LMRRRGRKRKSQQGDEDVTLKRSGTRRRYQDD-GISDDEIDGRRTFDLEEKLHSS-FFSSDRVKR 79

  Fly    90 MRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQ 154
            |.|.|.:..::|:||...|::|....|||::|||| :||||||:|.|||||::|||||.|||..:
Zfish    80 MEGKDFSYEYVQRHGLRDPIIFEKPEGLGIKMPDP-DFTVNDVKLFVGSRRIVDVMDVATQKGTE 143

  Fly   155 MTMKEWQQYYDSP--QKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGT 217
            |:|.:|::||::|  |:::|.||||||||||:|:..|:.|..|..|||||.:||:.||:.||:.|
Zfish   144 MSMAQWRRYYETPPSQREKLYNVISLEFSHTKLETLVKRPSTVDMIDWVDNMWPRHLKERQRDST 208

  Fly   218 NLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLS 282
            |.:..|.||||||||||||:.||||||||||||||||||.:|.|||||||||.:||:|||.||||
Zfish   209 NSIMEMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHIHKGCKVFWLIPPTPQNLELYENWVLS 273

  Fly   283 GKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVE 347
            |||.|||.||....|.|:.|..|.||.||:|||||||||..:|||||||||||.:..||..:.:|
Zfish   274 GKQGDIFLGDRATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNVPMQLDISGIE 338

  Fly   348 DSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSH---------------------LEGEASLSED 391
            |.|:||.|||||||.||.||||.||:::|...||                     |.|.|....|
Zfish   339 DRTRVPVKFRYPFFFEMCWYVLERYLYSLTNKSHLIPEFQKHSLGIGLKRENSEVLNGHAKEERD 403

  Fly   392 EM-AARP------HTHLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCK 449
            || |..|      .||||..||.||..:|..|..||..||.|||.:.:..||:.|:|:|::.|..
Zfish   404 EMDAPSPPSAPGLKTHLTAFELEGLWRLVGKLESLPSNKKCVPSGIHNAAALLLDIRALLKEHAN 468

  Fly   450 DQQDLAITGVSVL---KSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAE 511
            |...|:.||..::   |.||..|||
Zfish   469 DIPKLSYTGRPIVRWPKRPPWYQPP---------------------------------------- 493

  Fly   512 SDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKM 576
                                                                |.      ||..|
Zfish   494 ----------------------------------------------------PP------PPPVM 500

  Fly   577 H--LATALVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEG 639
            .  |||..:...                                ||..|.. :||:
Zfish   501 RPKLATTPIVPR--------------------------------PVKPASN-MSVL--------- 523

  Fly   640 GQVGGILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGP 704
                                            ||||.|||.|.||.|::||.|.||.||.|||||
Zfish   524 --------------------------------RRRRVRCKRCEACLRTECGDCNFCRDMKKFGGP 556

  Fly   705 GRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPD 769
            |:.||||::||||:|.||::|.|..|. :|.::|              ...|||||.|.:||||.
Zfish   557 GKLKQTCVLRQCLAPGLPLSAVCELCG-EGNQET--------------SEELMECSNCAQIAHPS 606

  Fly   770 CALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQG 834
            |.         ....:|:||:|||:.||||.|. .||:.|.:     :.....::.....|.|:|
Zfish   607 CL---------KTSGEGVVNKDLPSCWECPKCV-LGKDTDSE-----SSGSGDDITAQDGSGGRG 656

  Fly   835 GAEG--HADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVKTERNNSCD 897
            |..|  |..|.    ||            |.:..|::.......:..:::    .:|.:...|..
Zfish   657 GEGGAWHGVGR----PP------------SSLSHGSLQKRAAAPEQRLRK----RIKLDGGKSHK 701

  Fly   898 TPSPGISPNAIGGDSKVGKRR---------KSDDG-----TSVSSSMHES--------NDAPCGS 940
            ..|..:.|..    :|:.:|.         ..|||     :||.||:..|        .....||
Zfish   702 RKSSSLDPRV----AKIYRRHGMEHDDDSGSDDDGDGGRMSSVRSSVSSSRRGYGASRRGVWRGS 762

  Fly   941 SAEGAGGAGNANVSTNQW------SGSGGG-----GGSR-------------------------- 968
            |..|..|.|:.:.|:.:.      .|..||     |||:
Zfish   763 SQRGPRGGGSLSSSSLKMRRGLGARGERGGRVRLRGGSQMRRRRYETDDDDDDDDDDDDDDDDDD 827

  Fly   969 --------------------KKNSIR--------------------------------------- 974
                                |::..|
Zfish   828 DEDEDDEDDSEEDRHVSRSEKEHRSRRRRRRGDDYDDDEDEDDDDEEDSEEQDYEGEDDEMEDLD 892

  Fly   975 -------------------------SQLAQQMLNSS--TRVLKKP--------------QYVVRP 998
                                     |.|...:||.|  |..|.:|              :..:.|
Zfish   893 DGGDEDDEDGENQSDSDPDPPVLLVSDLNDDLLNDSYLTVTLHRPPKAKRDPGSIVPKLEAAMSP 957

  Fly   999 ASG-----------------TGSSSSSGNG-GSASATNGISNGSNQSGANSCGAGNGERGTNNGG 1045
            .:|                 |.||:.:||| ..|.:.......|||.|.        ||.|.:..
Zfish   958 RTGGSSGFMQRKTLPKARPKTSSSTPAGNGLSQAKSGRPTRRSSNQDGR--------ERDTASPS 1014

  Fly  1046 LSGSNG------------------LGNQHYSSSQN-LALDPTVLKIIFRYLPQDTLVTCCSVCKV 1091
            ...|..                  |.:..:..:.| |..:..:...:||||.:..|..|..|||.
Zfish  1015 SMSSRSSVSPPPPPPAVTSSSPSLLSHPSFRDAGNELGCEKDIWVSVFRYLDRTDLAVCMRVCKA 1079

  Fly  1092 WSNAAVDPDLWKKMNCSE-HKMSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSL 1155
            |.....|..||.:::.|. ..:|...:|||::.||..|.|.||.::|:|||||:..||:||:|.:
Zfish  1080 WFKWCCDKRLWTRIDLSRCRALSPQAVTAIIKLQPVTLDLSWTPVSKKQLAWLIHHLPSLKDLIM 1144

  Fly  1156 QNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLA 1220
            ..|....|.||.:..||.|:||||.:..|:.|:.|:|::     .:|| |:|::|||.|..::|:
Zfish  1145 SGCSSLCVSALSSPSCPSLRTLDLCWAVGVKDSQIKDLI-----VQPG-SESRSRLRSLVSLRLS 1203

  Fly  1221 GTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATAR--LTELNLSACRLVSENA 1283
            |.::||..::.:.:.:|.||.||||.||.:||..: .:.|:|....|  |.:||||.|..:|:..
Zfish  1204 GLELSDAVIKTMVRHMPSLRQLDLSYCQGLTDQSI-NLLTATGCNTRNTLRQLNLSGCNKLSDGC 1267

  Fly  1284 LEHLAKCEGLIWLDLRHVPQVSTQSVIRFASNSKH--DLCVRDIKLVER 1330
            |.::.:...|..||||....|:......|.|:..:  ..|:.:.||::|
Zfish  1268 LSYMKRLSALALLDLRGCKNVTRHGCENFISDLSYCTVFCLTEDKLIQR 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	73/99 (74%)
		PRTases_typeI	<394..>467	CDD:294217	31/81 (38%)
		zf-CXXC	670..716	CDD:251032	29/45 (64%)
		PHD_4	721..801	CDD:293471	28/79 (35%)
		F-box-like	<1073..1108	CDD:289689	13/34 (38%)
		leucine-rich repeat	1102..1125	CDD:275381	6/23 (26%)
		leucine-rich repeat	1126..1149	CDD:275381	11/22 (50%)
		leucine-rich repeat	1150..1173	CDD:275381	8/22 (36%)
		AMN1	1166..>1320	CDD:187754	54/157 (34%)
		leucine-rich repeat	1174..1213	CDD:275381	15/38 (39%)
		leucine-rich repeat	1214..1238	CDD:275381	5/23 (22%)
		leucine-rich repeat	1239..1267	CDD:275381	12/27 (44%)
		leucine-rich repeat	1268..1292	CDD:275381	8/23 (35%)
		leucine-rich repeat	1293..1317	CDD:275381	8/23 (35%)
kdm2aa	XP_005160305.1	cupin_like	222..322	CDD:304367	73/99 (74%)
		zf-CXXC	<534..568	CDD:251032	21/33 (64%)
		PHD_4	573..629	CDD:293471	28/79 (35%)
		F-box-like	1056..1096	CDD:289689	13/39 (33%)
		leucine-rich repeat	1065..1087	CDD:275381	7/21 (33%)
		leucine-rich repeat	1090..1114	CDD:275381	6/23 (26%)
		leucine-rich repeat	1115..1138	CDD:275381	11/22 (50%)
		AMN1	1116..1291	CDD:187754	70/181 (39%)
		leucine-rich repeat	1139..1162	CDD:275381	8/22 (36%)
		leucine-rich repeat	1163..1196	CDD:275381	15/38 (39%)
		leucine-rich repeat	1197..1221	CDD:275381	5/23 (22%)
		leucine-rich repeat	1222..1248	CDD:275381	12/26 (46%)
		leucine-rich repeat	1252..1276	CDD:275381	8/23 (35%)
		leucine-rich repeat	1277..1296	CDD:275381	6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2068
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56564
Inparanoid	1	1.050	794	1.000	Inparanoid score	I491
OMA	1	1.010	-	-		QHG50015
OrthoDB	1	1.010	-	-		D165446at33208
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	1	1.000	-	-		otm25557
orthoMCL	1	0.900	-	-		OOG6_104082
Panther	1	1.100	-	-	O	PTHR23123
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1005
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.980