DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and fbxl7

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001073511.1	Gene:	fbxl7 / 569430	ZFINID:	ZDB-GENE-061215-122	Length:	489	Species:	Danio rerio

Alignment Length:	468	Identity:	113/468 - (24%)
Similarity:	172/468 - (36%)	Gaps:	142/468 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 GAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLK------------------KPQ 993
            ||.|     .:.|||.|.|.|    ||.|.|:.....:||:..|                  .|.
Zfish     2 GANN-----GKQSGSEGKGSS----SISSDLSSSTDQTSTKAPKNAATSEDSDLSMRTVSTPSPA 57

  Fly   994 YVVRPASGT----GSSSSSGNGGS----------ASATNG---ISNGSNQSGANSCGAGNGERGT 1041
            .::.|.|.:    |||:||...|:          .|.|:.   :....:|.||
Zfish    58 LILPPRSSSAVLNGSSTSSSTFGTETIAMVHMPPTSLTHPQRCLRQPRDQQGA------------ 110

  Fly  1042 NNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMN 1106
                              ..::..|...|: ||.:||.:.|..|..||:.|.|.|.||.||:.:.
Zfish   111 ------------------PVDILPDHAFLQ-IFTHLPTNQLCRCARVCRRWYNLAWDPRLWRTIR 156

  Fly  1107 CSEHKMSAS-LLTAIVRRQPEH-----------LILDWTQIAKRQLAWLVARLPALKNLSLQNC- 1158
            .:...:... .|..:.||..:.           ::....::..|.|..:....|.|:.|.:..|
Zfish   157 LTGDVLHVDRALRVLTRRLCQDTPNVCLTVETVMVSGCRRLTDRGLYTVAQSCPELRRLEVAGCY 221

  Fly  1159 --PIQAVLALHTCLCPPLQTLDLSFVRGLNDAAI-RDI---LSPPKDSRP-----------GLSD 1206
              ..:||..: ...||.|:.||:|....:...:: ||:   |||....:.           .|.|
Zfish   222 NVSNEAVFEV-VSRCPNLEHLDVSGCSKVTCISLTRDVSVKLSPLHGQQISIRFLDMTDCFALED 285

  Fly  1207 SK-------------------TRLRD--LK--------VMKLAGTD---ISDVAVRYITQSLPYL 1239
            ..                   .||.|  |:        |.:|:.:|   |||..:|.|.:....|
Zfish   286 EGLHTIAAHCTQLTHLYLRRCVRLTDEGLRFLVIYCPGVRELSVSDCRFISDFGLREIAKLEGRL 350

  Fly  1240 RHLDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAK-CEGLIWLDLRHVPQ 1303
            |:|.::.|.||||.||..:   ....:||..||...|..::::.:||||| |..|..||:...|.
Zfish   351 RYLSIAHCSRITDVGVRYV---AKYCSRLRYLNARGCEGLTDHGIEHLAKSCLKLKSLDIGKCPL 412

  Fly  1304 VSTQSVIRFASNS 1316
            ||...:.:.|.||
Zfish   413 VSDAGLEQLALNS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	15/34 (44%)
		leucine-rich repeat	1102..1125	CDD:275381	4/23 (17%)
		leucine-rich repeat	1126..1149	CDD:275381	2/33 (6%)
		leucine-rich repeat	1150..1173	CDD:275381	6/25 (24%)
		AMN1	1166..>1320	CDD:187754	55/199 (28%)
		leucine-rich repeat	1174..1213	CDD:275381	13/72 (18%)
		leucine-rich repeat	1214..1238	CDD:275381	9/34 (26%)
		leucine-rich repeat	1239..1267	CDD:275381	10/27 (37%)
		leucine-rich repeat	1268..1292	CDD:275381	10/24 (42%)
		leucine-rich repeat	1293..1317	CDD:275381	9/24 (38%)
fbxl7	NP_001073511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		22/82 (27%)
		F-box-like	112..158	CDD:289689	17/46 (37%)
		leucine-rich repeat	127..151	CDD:275381	11/23 (48%)
		leucine-rich repeat	152..185	CDD:275381	4/32 (13%)
		LRR 1	168..193		3/24 (13%)
		AMN1	<183..364	CDD:187754	40/181 (22%)
		leucine-rich repeat	186..211	CDD:275381	2/24 (8%)
		LRR 2	194..219		5/24 (21%)
		leucine-rich repeat	212..233	CDD:275381	5/21 (24%)
		LRR 3	220..245		8/25 (32%)
		leucine-rich repeat	238..271	CDD:275381	9/32 (28%)
		LRR 4	251..279		5/27 (19%)
		leucine-rich repeat	272..297	CDD:275381	2/24 (8%)
		LRR 5	280..305		2/24 (8%)
		AMN1	295..463	CDD:187754	42/134 (31%)
		leucine-rich repeat	298..323	CDD:275381	4/24 (17%)
		LRR 6	306..331		6/24 (25%)
		leucine-rich repeat	324..349	CDD:275381	8/24 (33%)
		LRR 7	332..357		8/24 (33%)
		leucine-rich repeat	350..375	CDD:275381	10/27 (37%)
		LRR 8	358..383		11/27 (41%)
		leucine-rich repeat	376..401	CDD:275381	10/24 (42%)
		LRR 9	384..409		10/24 (42%)
		leucine-rich repeat	402..427	CDD:275381	9/24 (38%)
		LRR 10	410..435		6/16 (38%)
		leucine-rich repeat	428..451	CDD:275381
		LRR 11	436..461
		leucine-rich repeat	454..478	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810