DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and FBXL19

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001093254.2	Gene:	FBXL19 / 54620	HGNCID:	25300	Length:	694	Species:	Homo sapiens

Alignment Length:	752	Identity:	217/752 - (28%)
Similarity:	325/752 - (43%)	Gaps:	181/752 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 GGGAKLSPNLTGTGQ-----PRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQ 715
            |..|.|:|.::.:.:     .|||||||:.|.||.|::||.|.||.||.|||||||.||:|::||
Human    12 GPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQ 76

  Fly   716 CLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTED 780
            |.:|:||.||.|:.|...|...|....:.|...|      ||||::|.||.||.|.        .
Human    77 CTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLS------LMECTICNEIVHPGCL--------K 127

  Fly   781 AADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHAD---- 841
            ...|:|::|.::||.||||.|.:.|                    |.|...|:|.....||
Human   128 MGKAEGVINAEIPNCWECPRCTQEG--------------------RTSKDSGEGPGRRRADNGEE 172

  Fly   842 GNTL-----------LPP---------PVGQYNDFV--FTSESEMESGT--------VSGHMTHW 876
            |.:|           |||         |.|...:.|  .....|.|:|.        |.|
Human   173 GASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKG----- 232

  Fly   877 KHGMKRHHQLEVKTERNNSC-----DTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHE---- 932
              |.:||    :|....::|     |...||:.|..:...|:            ..||.|.
Human   233 --GRERH----LKKVGGDACLLRGSDPGGPGLLPPRVLNPSQ------------AFSSCHPGLPP 279

  Fly   933 ---SNDAPCGSSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQY 994
               ....|..:||||.                          ::.|...|:   ......|:...
Human   280 ENWEKPKPPLASAEGP--------------------------AVPSPSPQR---EKLERFKRMCQ 315

  Fly   995 VVRPASGTGSSSSSGNGGSASATNGISN----GSNQSGANSCGAGNGERGTNNGG----LSGSNG 1051
            ::.....|.||||..:..|.|:...:|.    |..::|.......:||: .|.||    ..||.|
Human   316 LLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK-ENRGGRRAVRPGSGG 379

  Fly  1052 ------LG----------NQHYSSSQNLALDPTVLKI---------------IFRYLPQDTLVTC 1085
                  ||          .:|.......:.:|..|.:               :|::|....|..|
Human   380 PLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCIC 444

  Fly  1086 CSVCKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPA 1149
            ..||:.||....|..||.:|:.|..| ::..:|:.:|||||..|.|.||.::|:||.||:.||..
Human   445 MRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQG 509

  Fly  1150 LKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDL 1214
            |:.|.|..|...:|.||.:...|.|:.|||.::..:.|:.:|::|.||.|::||.::|:.||:.:
Human   510 LQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGV 574

  Fly  1215 KVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATAR--LTELNLSACR 1277
            ..::|||.:::|.::|.:.:..|.|..||||.|..:.|..| .:.|:.|:..|  |..|||:.|.
Human   575 AELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSV-HLLTAPTSPLRETLVHLNLAGCH 638

  Fly  1278 LVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFAS 1314
            .::::.|....:|..|..||||...|:|.::..|.|:
Human   639 RLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAA 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032	29/50 (58%)
		PHD_4	721..801	CDD:293471	29/79 (37%)
		F-box-like	<1073..1108	CDD:289689	12/34 (35%)
		leucine-rich repeat	1102..1125	CDD:275381	8/23 (35%)
		leucine-rich repeat	1126..1149	CDD:275381	11/22 (50%)
		leucine-rich repeat	1150..1173	CDD:275381	7/22 (32%)
		AMN1	1166..>1320	CDD:187754	50/151 (33%)
		leucine-rich repeat	1174..1213	CDD:275381	15/38 (39%)
		leucine-rich repeat	1214..1238	CDD:275381	5/23 (22%)
		leucine-rich repeat	1239..1267	CDD:275381	10/27 (37%)
		leucine-rich repeat	1268..1292	CDD:275381	7/23 (30%)
		leucine-rich repeat	1293..1317	CDD:275381	9/22 (41%)
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		4/19 (21%)
		zf-CXXC	<50..77	CDD:251032	18/26 (69%)
		PHD_FXL19	87..148	CDD:277115	25/74 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..420		64/342 (19%)
		F-box-like	424..465	CDD:315592	11/40 (28%)
		leucine-rich repeat	461..485	CDD:275381	8/23 (35%)
		AMN1	466..665	CDD:332986	71/199 (36%)
		leucine-rich repeat	486..508	CDD:275381	10/21 (48%)
		LRR 1	492..517		12/24 (50%)
		leucine-rich repeat	510..533	CDD:275381	7/22 (32%)
		LRR 2	518..541		9/22 (41%)
		leucine-rich repeat	534..573	CDD:275381	15/38 (39%)
		leucine-rich repeat	574..598	CDD:275381	5/23 (22%)
		LRR 3	581..606		8/24 (33%)
		leucine-rich repeat	599..623	CDD:275381	9/24 (38%)
		LRR 4	607..636		10/29 (34%)
		leucine-rich repeat	629..653	CDD:275381	7/23 (30%)
		LRR 5	637..661		7/23 (30%)
		leucine-rich repeat	654..686	CDD:275381	9/22 (41%)
		LRR 6	662..694		4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5485
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165446at33208
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920