DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_056609.1	Gene:	Fbxl17 / 50758	MGIID:	1354704	Length:	701	Species:	Mus musculus

Alignment Length:	749	Identity:	147/749 - (19%)
Similarity:	231/749 - (30%)	Gaps:	251/749 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 QPRRRRTRCKNCAACQR---------------SDCGTCPFCMDMVKFGGPGRAKQTCMMRQCL-- 717
            :|.::|.||  |:.|:|               |.....|...|.. |.||      ||:  |.
Mouse    12 RPSQKRPRC--CSWCRRRRPLLRLPRRALAKASPQPAAPRSRDCF-FRGP------CML--CFIV 65

  Fly   718 -SPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYE----IAHPDCA------ 771
             ||..|.:|...       .:.|:||...  ...||..|.:.......    :|..|||
Mouse    66 HSPGAPASAGLE-------EEPPLSPPPP--PPRDGAYAAVSSQHLARRYAALAAEDCAAAARRF 121

  Fly   772 -LSQLDGTEDAADAKGIVNEDL----PNSWECPSCCRSGKNY---DYKPRHFRARQKSSEVRRVS 828
             ||.......||.:.....::|    ..:||     :.|::.   ...|..|.....:.::.|..
Mouse   122 LLSSAAAAAAAASSPASCCKELGLAAAAAWE-----QQGRSLFLAGVGPVRFLGPLAAVQLFRAP 181

  Fly   829 VSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVKTERN 893
            .:                |||             :.|..|.                ||:..:|.
Mouse   182 PA----------------PPP-------------QAEPATA----------------LEMVCKRK 201

  Fly   894 NS-------CDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAEGAGGAGNA 951
            .:       |..|..|                                   ||....|.||.|
Mouse   202 GAGVPACTPCKQPRCG-----------------------------------CGGCGGGGGGGG-- 229

  Fly   952 NVSTNQWSGSGGGGGS--RKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPAS----------GTGS 1004
                    |..|||.|  |..::...|..:|         ..|.....|||          ..|.
Mouse   230 --------GPAGGGASPPRPPDAGCCQAPEQ---------PPPPLCPAPASPASECAPIVAAAGD 277

  Fly  1005 SSSSGNGGSASATNGISNGS---NQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNL--- 1063
            :..:|....:||.....:|.   .:...|.|..                     |......:
Mouse   278 TVRAGGTAPSSAQQQPESGDADCQEPPENPCDC---------------------HREPPPEIPDI 321

  Fly  1064 -ALDPTVLKIIFRYLP-QDTLVTCCSVCKVWSNAAVDPDLWKKMN-CSEHKMSASLLTAIVRRQP 1125
             .|.|::|..||..|. .:..::...|||.|.:..:|...||::: .|..:::..||..|..|..
Mouse   322 NQLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQ 386

  Fly  1126 ---EHLILDWTQIAKRQLAWLVARLPALKNLSLQNC------PIQAVLALHTCLCPPLQTLDLSF 1181
               |..|.|...::...:..|..:.|.|...:...|      .|.|| |.|   ||.||.:.:..
Mouse   387 NIIEINISDCRSLSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAV-ASH---CPLLQKVHVGN 447

  Fly  1182 VRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGT-DISDVAVRYITQSLPYLRHLDLS 1245
            ...|.|              .||....:|.|:||.:..... .|||..:..|.:|...|:.:.:.
Mouse   448 QDKLTD--------------EGLKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCLKLQRIYMQ 498

  Fly  1246 SCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVI 1310
            ..:.:||..|......   ...|..:....|.:.|:..: ||.|...|..|||||:.::..::|:
Mouse   499 ENKLVTDQSVKAFAEH---CPELQYVGFMGCSVTSKGVI-HLTKLRNLSSLDLRHITELDNETVM 559

  Fly  1311 RFASNSKH----DLCV------RDIKLVERRRRN 1334
            ......|:    :||:      |.::::.:..:|
Mouse   560 EIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032	15/60 (25%)
		PHD_4	721..801	CDD:293471	19/94 (20%)
		F-box-like	<1073..1108	CDD:289689	10/36 (28%)
		leucine-rich repeat	1102..1125	CDD:275381	7/23 (30%)
		leucine-rich repeat	1126..1149	CDD:275381	4/22 (18%)
		leucine-rich repeat	1150..1173	CDD:275381	8/28 (29%)
		AMN1	1166..>1320	CDD:187754	36/158 (23%)
		leucine-rich repeat	1174..1213	CDD:275381	7/38 (18%)
		leucine-rich repeat	1214..1238	CDD:275381	7/24 (29%)
		leucine-rich repeat	1239..1267	CDD:275381	4/27 (15%)
		leucine-rich repeat	1268..1292	CDD:275381	6/23 (26%)
		leucine-rich repeat	1293..1317	CDD:275381	7/23 (30%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..250		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..321		7/62 (11%)
		F-box-like	321..368	CDD:289689	13/46 (28%)
		leucine-rich repeat	362..387	CDD:275381	7/24 (29%)
		leucine-rich repeat	388..413	CDD:275381	4/24 (17%)
		AMN1	411..573	CDD:187754	43/183 (23%)
		leucine-rich repeat	414..439	CDD:275381	8/28 (29%)
		leucine-rich repeat	440..465	CDD:275381	7/38 (18%)
		leucine-rich repeat	466..491	CDD:275381	7/24 (29%)
		leucine-rich repeat	492..517	CDD:275381	4/27 (15%)
		leucine-rich repeat	545..567	CDD:275381	6/21 (29%)
		leucine-rich repeat	568..593	CDD:275381	3/24 (13%)
		leucine-rich repeat	594..618	CDD:275381	147/749 (20%)
		leucine-rich repeat	619..644	CDD:275381
		leucine-rich repeat	645..670	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810