DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and kdm2ba

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_021333907.1	Gene:	kdm2ba / 406446	ZFINID:	ZDB-GENE-040426-2195	Length:	873	Species:	Danio rerio

Alignment Length:	955	Identity:	252/955 - (26%)
Similarity:	374/955 - (39%)	Gaps:	292/955 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 EYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGG 595
            :|.:...:::||.|                          :|..||..:||...:|.:|||
Zfish    13 DYDSDTAEQQQLPN--------------------------KPKPKMATSTATTPSATTSSS---- 47

  Fly   596 PVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAK 660
                                              .||:                         .|
Zfish    48 ----------------------------------TATA-------------------------VK 53

  Fly   661 LSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLSPMLPVTA 725
            |..|.|.:| .|||||||:.|.||.|::||.|.||.||.|||||||.||:|:||||::|:||.||
Zfish    54 LPSNRTSSG-ARRRRTRCRKCEACVRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTA 117

  Fly   726 QCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAADAKGIVNE 790
            .||.|...|...|......|..|      .|||||:|.||.||:|.        ...||.|:||:
Zfish   118 VCVVCGEAGKEDTLDDEDEKFNA------MLMECSICNEIVHPNCL--------KVKDAAGVVND 168

  Fly   791 DLPNSWECPSCCRSGKNYDYKPRHFRARQK-------SSEVRRVSVSHGQGGAEGHADGN----- 843
            :|||.||||.|..:||...      ..:||       :|.:....:...:.|.:|..:|:
Zfish   169 ELPNCWECPKCNYAGKTGK------ACKQKRGPGFKYASNLPGSLLREQKAGRDGREEGDQTSTG 227

  Fly   844 ----------------------TLLPP---------PVGQYNDF------VFTSESEMESGTVS- 870
                                  :.|||         |..:..:|      :|..:.|.|..:..
Zfish   228 PASIKRKTEREETPRLKTEDLPSRLPPLLSPSGLPRPRSEVPNFLRKKRKLFDDDEEEEEASAKK 292

  Fly   871 -------------GHMTHWK----------------------HGMKRHHQL-----EVKTERNNS 895
                         ..::|.|                      ..:|:.:.:     |.:.||...
Zfish   293 KQKKPWRPEEPLIPKLSHMKAEEEEDNSDEEEERQEKREQPRRSIKKDYSIVRKEEEREEERRED 357

  Fly   896 CDTPSPGISPNAIGGDSKVGKRRKSDD------------GTSVSSSMH------ESNDAPCGSSA 942
            .|.|...:.........:.....|.||            |...|.::.      ||:.:.|.|..
Zfish   358 RDPPFRSLKEFHNMSKEEDNDEEKEDDDEEEEEESNGKRGRDSSPALKNLSLSLESDASRCSSPR 422

  Fly   943 EGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSSS 1007
            .|....|:   .|.:.:........|:|...| ||:.::.......:::.::.:...:.....|.
Zfish   423 AGPSSEGS---ETQEKAPRARARRHRRKPPNR-QLSAELSKQLNMEIRRTEHSLANENQQPLMSE 483

  Fly  1008 SGNGGSASATNGISNGSNQSGANSCGAGNG-ERGTNNGGLSGS----------NGLG--NQHYSS 1059
            ..:..:.....|:.||   :..|:.|.|.| |||.  ||.:|.          ||..  .:|:..
Zfish   484 PEDSENEEPKRGLRNG---TAGNAGGGGGGVERGA--GGEAGGERPHLRAREMNGTSWELRHFYP 543

  Fly  1060 SQNLAL-----DPTVLKI---------------------------------------------IF 1074
            .|...|     .|||..:                                             ||
Zfish   544 PQITPLGLNRSSPTVRPLPARSPPKCVQMERHVIRPPPICPPPDRLPLADGRNHIAPREAWLAIF 608

  Fly  1075 RYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKR 1138
            .:|....|..|..||:.|:....|..||.:::....| ::..:|:.|:||||..|.|.||.|:|:
Zfish   609 SHLSHRELCVCMRVCRTWNRWCCDKRLWTRIDLKRCKSITPLMLSGIIRRQPITLDLSWTNISKK 673

  Fly  1139 QLAWLVARLPALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPG 1203
            ||:||:.|||.|:.|.|..|...||.||.|..||.|:||||.:|.||.|..:||:||||.|:|||
Zfish   674 QLSWLINRLPGLRVLLLSGCSWVAVSALCTSSCPLLRTLDLQWVEGLKDPQMRDLLSPPTDNRPG 738

  Fly  1204 LSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQI-GTSTTATAR 1267
            ..|::::||::..::|||.||:|.::|.|.:::|.|..||||.|..|.|..|..: ...||....
Zfish   739 QMDTRSKLRNVTDLRLAGLDITDSSLRLIIKNMPLLSRLDLSYCNHINDQSVNLLTAAGTTTRDS 803

  Fly  1268 LTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRF 1312
            ||::|||.|..|::.:|.:..:|..:..:|:|...|||.|:..||
Zfish   804 LTDVNLSVCNRVTDQSLSYFKRCGSICRIDMRFSKQVSRQACERF 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032	30/45 (67%)
		PHD_4	721..801	CDD:293471	34/79 (43%)
		F-box-like	<1073..1108	CDD:289689	11/34 (32%)
		leucine-rich repeat	1102..1125	CDD:275381	6/23 (26%)
		leucine-rich repeat	1126..1149	CDD:275381	12/22 (55%)
		leucine-rich repeat	1150..1173	CDD:275381	10/22 (45%)
		AMN1	1166..>1320	CDD:187754	63/148 (43%)
		leucine-rich repeat	1174..1213	CDD:275381	21/38 (55%)
		leucine-rich repeat	1214..1238	CDD:275381	8/23 (35%)
		leucine-rich repeat	1239..1267	CDD:275381	11/28 (39%)
		leucine-rich repeat	1268..1292	CDD:275381	9/23 (39%)
		leucine-rich repeat	1293..1317	CDD:275381	8/20 (40%)
kdm2ba	XP_021333907.1	zf-CXXC	<72..108	CDD:251032	23/35 (66%)
		PHD_KDM2B	118..179	CDD:277114	30/74 (41%)
		F-box-like	600..640	CDD:315592	11/39 (28%)
		leucine-rich repeat	611..633	CDD:275381	6/21 (29%)
		leucine-rich repeat	636..660	CDD:275381	6/23 (26%)
		AMN1	638..846	CDD:332986	88/207 (43%)
		leucine-rich repeat	661..684	CDD:275381	12/22 (55%)
		leucine-rich repeat	685..708	CDD:275381	10/22 (45%)
		leucine-rich repeat	709..745	CDD:275381	20/35 (57%)
		leucine-rich repeat	746..773	CDD:275381	10/26 (38%)
		leucine-rich repeat	774..803	CDD:275381	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5515
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	794	1.000	Inparanoid score	I491
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165446at33208
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104082
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1005
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960