DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and Fbxl22

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001102239.1	Gene:	Fbxl22 / 363083	RGDID:	1311830	Length:	236	Species:	Rattus norvegicus

Alignment Length:	240	Identity:	55/240 - (22%)
Similarity:	88/240 - (36%)	Gaps:	65/240 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1073 IFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSASLLTAIVRRQPEHLILDWTQIAK 1137
            :|.:|.:|:..:....|....:...||.||..::.  |.:                    |::.|
  Rat    14 LFSFLDKDSRKSLSRTCSQLRDVFEDPTLWSLLHF--HSL--------------------TELKK 56

  Fly  1138 RQLAWLVARL-PALKNLSL-------QNCPIQAVL--ALHTCLCPPLQTLDLSFVRGLNDAAIRD 1192
            ...     || |||::||:       |.|.|:..|  |....:|...:.|            :.|
  Rat    57 DNF-----RLSPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSQHENL------------VND 104

  Fly  1193 ILSPPKDSRPGLSDSKTRLRDLKVMKLAGT-DISDVAVRYITQSLPYLRHLDLSSCQRITDAGVA 1256
            .|....:..|.|:.          :.|:|. .::|..:..:....|.||.|.|.:|.|:|:..:|
  Rat   105 FLLQVCNRCPNLAS----------VTLSGCGHVTDDCLARLLLGCPRLRALRLENCARVTNRTLA 159

  Fly  1257 QIGTSTTATARLTELNLSACRLVSENALEHL-AKCEGLIWLDLRH 1300
            .:.....|   |...::..||.||...|..| |.|..|| |...|
  Rat   160 AVAAHGRA---LQTFHVDFCRNVSAAGLLRLRAACPNLI-LSAEH 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	8/34 (24%)
		leucine-rich repeat	1102..1125	CDD:275381	2/22 (9%)
		leucine-rich repeat	1126..1149	CDD:275381	4/23 (17%)
		leucine-rich repeat	1150..1173	CDD:275381	9/31 (29%)
		AMN1	1166..>1320	CDD:187754	32/137 (23%)
		leucine-rich repeat	1174..1213	CDD:275381	5/38 (13%)
		leucine-rich repeat	1214..1238	CDD:275381	3/24 (13%)
		leucine-rich repeat	1239..1267	CDD:275381	9/27 (33%)
		leucine-rich repeat	1268..1292	CDD:275381	9/24 (38%)
		leucine-rich repeat	1293..1317	CDD:275381	4/8 (50%)
Fbxl22	NP_001102239.1	F-box-like	3..43	CDD:403981	6/28 (21%)
		AMN1	44..>191	CDD:187754	42/198 (21%)
		leucine-rich repeat	116..141	CDD:275381	4/34 (12%)
		leucine-rich repeat	142..167	CDD:275381	8/24 (33%)
		leucine-rich repeat	168..193	CDD:275381	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900