DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm2 and Kdm2a

DIOPT Version :10

Sequence 1:NP_649864.2 Gene:Kdm2 / 41090 FlyBaseID:FBgn0037659 Length:1345 Species:Drosophila melanogaster
Sequence 2:NP_001101985.1 Gene:Kdm2a / 361700 RGDID:1309419 Length:1161 Species:Rattus norvegicus


Alignment Length:1405 Identity:471/1405 - (33%)
Similarity:642/1405 - (45%) Gaps:352/1405 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 LSPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLT 96
            :.|..:.::..|......|:.| |:..:.|::.||.|.|.:.|||.::|: .|..|..|.|.|..
  Rat     1 MEPEEERIRYSQRLRGTMRRRY-EDDGISDDEIEGKRTFDLEEKLHTNKY-NANFVTFMEGKDFN 63

  Fly    97 VAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQ 161
            |.::|:.|...||:|::..|||::|||| :||||||::||||||::|||||||||.::|||.:|.
  Rat    64 VEYIQRGGLRDPLIFKNSDGLGIKMPDP-DFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWT 127

  Fly   162 QYYDSPQKDR--LLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMM 224
            :||::|:::|  |.||||||||||||:..||.|..|..|||||.:||:.||::|.|.||.:..|.
  Rat   128 RYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQ 192

  Fly   225 YPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIF 289
            ||||||||||||:.||||||:|||||||||||.:|.|||||||||..||:|||.|:|||||.|||
  Rat   193 YPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIF 257

  Fly   290 FGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQ 354
            .||.|..|.|:.|..|.||.||:||||||||||.:|||||||||||.|..|||..|:||.|:||.
  Rat   258 LGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPN 322

  Fly   355 KFRYPFFTEMLWYVLARYVHTLLGHSHLEGE---ASLS-----------------EDEMAARPHT 399
            ||||||:.||.||||.|||:.:...|||..|   .|||                 .|:.|.|.::
  Rat   323 KFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDMELNELESGNGDEEGADKEARRMNS 387

  Fly   400 ----------------------------------------------------------------H 400
                                                                            |
  Rat   388 KRSVLTSPVANGVNLDYDGLGKACRSLPNLKKTLSGDSSSDSSRGSHNGQVWDPQCSPRKDRQVH 452

  Fly   401 LTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVLKSP 465
            |||.||.||:.:|..|..||..||.||:.:.|..|||.||:.|:|........||:|||.:::.|
  Rat   453 LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWP 517

  Fly   466 PGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGV 530
            ...:..|....:.||                                                  
  Rat   518 KRDKLKFPTRPKVRV-------------------------------------------------- 532

  Fly   531 EYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGG 595
                                               .|:....|..|..|..|.            
  Rat   533 -----------------------------------PTIPITKPHTMKPAPRLT------------ 550

  Fly   596 PVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAK 660
            ||.....|.:              |:||                                     
  Rat   551 PVRPAAASPI--------------VSGA------------------------------------- 564

  Fly   661 LSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLSPMLPVTA 725
                       ||||.||:.|.||.:.:||.|.:|.||.|||||||.||:|::||||:|.||.:.
  Rat   565 -----------RRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSV 618

  Fly   726 QCVYC-HLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAADAKGIVN 789
            .|..| .:|...:|           .|....||||.:|.||.||.|.  |:||       :|::|
  Rat   619 TCSLCGEVDQNEET-----------QDFEKKLMECCICNEIVHPGCL--QMDG-------EGLLN 663

  Fly   790 EDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLPPPVGQYN 854
            |:|||.||||.|.:...:...:.|  :..:...|..:..|.......|     ..|.|||...  
  Rat   664 EELPNCWECPKCYQEDSSEKAQKR--KIEESDEEAVQAKVLRPLRSCE-----EPLTPPPHSP-- 719

  Fly   855 DFVFTSESEMESGTVS--GHMTHWKHGMKRHHQLEVKTERNNSCDTPSPGISP---NAIGGDSKV 914
                ||..::....||  |.:|.                       .|||..|   ::...|.:.
  Rat   720 ----TSMLQLIHDPVSPRGMVTR-----------------------SSPGAGPSDHHSASRDERF 757

  Fly   915 GKRRKSDDGTSVSSSMHESNDAPCG----SSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRS 975
            .:|:......:..:.:.|..:.|.|    |..|.|...|:....|.|.......|     .||..
  Rat   758 KRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHG-----TSIVP 817

  Fly   976 QLAQQMLNSSTRVLKKPQYVVR--PASGTGSSSSSGNGGSASATNGISNGSNQSGANSCGAGNGE 1038
            :| |.:..||..:...|:.:::  ||.........|.||......               ....:
  Rat   818 KL-QAITASSANLRPNPRVLMQHCPARNPQRGDEEGLGGEEEEEE---------------EEEED 866

  Fly  1039 RGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWK 1103
            .....||.:..||.|:......::. :...|...:||||.:..|..|..|||.|.....|..||.
  Rat   867 DSAEEGGAARLNGRGSWAQDGDESW-MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWT 930

  Fly  1104 KMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALH 1167
            |::.|..| :....|:.|::|||..|.|.||.|:|:||.|||.|||.||:|.|..|...||.||.
  Rat   931 KIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALS 995

  Fly  1168 TCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYI 1232
            |..||.|:||||.:..|:.|..|||:|:||.| :|| .|::::||::...:|||.||:|..:|.|
  Rat   996 TSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTD-KPG-QDNRSKLRNMTDFRLAGLDITDATLRLI 1058

  Fly  1233 TQSLPYLRHLDLSSCQRITDAG---VAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLI 1294
            .:.:|.|..||||.|..:||..   :..:|:||..:  |||||::.|..:::..|..|.:...:.
  Rat  1059 IRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS--LTELNMAGCNKLTDQTLFFLRRIANVT 1121

  Fly  1295 WLDLRHVPQVSTQSVIRFAS----NSKHDLCVRDIKLVER 1330
            .:|||...|::.::...|.|    ||.:  |:.|.||:::
  Rat  1122 LIDLRGCKQITRKACEHFISDLSINSLY--CLSDEKLIQK 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm2NP_649864.2 cupin_RmlC-like 231..331 CDD:477354 73/99 (74%)
CTD_Jhd1-like 399..465 CDD:412024 29/129 (22%)
zf-CXXC 670..716 CDD:366873 26/45 (58%)
PHD_4 721..802 CDD:465288 30/81 (37%)
F-box-like <1073..1105 CDD:463757 13/31 (42%)
leucine-rich repeat 1102..1125 CDD:275381 7/23 (30%)
leucine-rich repeat 1126..1149 CDD:275381 13/22 (59%)
leucine-rich repeat 1150..1173 CDD:275381 11/22 (50%)
AMN1 1166..>1320 CDD:187754 59/160 (37%)
leucine-rich repeat 1174..1213 CDD:275381 18/38 (47%)
leucine-rich repeat 1214..1238 CDD:275381 8/23 (35%)
leucine-rich repeat 1239..1267 CDD:275381 11/30 (37%)
leucine-rich repeat 1268..1292 CDD:275381 8/23 (35%)
leucine-rich repeat 1293..1317 CDD:275381 7/27 (26%)
Kdm2aNP_001101985.1 cupin_RmlC-like 199..299 CDD:477354 73/99 (74%)
JHD 304..>339 CDD:465515 22/34 (65%)
CTD_KDM2A 450..517 CDD:412025 29/66 (44%)
zf-CXXC <576..609 CDD:366873 19/32 (59%)
PHD_KDM2A 619..675 CDD:277113 28/75 (37%)
F-box_FBXL11 885..931 CDD:438952 14/46 (30%)
leucine-rich repeat 929..953 CDD:275381 7/23 (30%)
AMN1 931..1137 CDD:187754 85/209 (41%)
leucine-rich repeat 954..977 CDD:275381 13/22 (59%)
leucine-rich repeat 978..1001 CDD:275381 11/22 (50%)
leucine-rich repeat 1002..1039 CDD:275381 18/38 (47%)
leucine-rich repeat 1040..1064 CDD:275381 8/23 (35%)
leucine-rich repeat 1065..1094 CDD:275381 11/28 (39%)
leucine-rich repeat 1095..1119 CDD:275381 8/23 (35%)
leucine-rich repeat 1120..1139 CDD:275381 4/18 (22%)

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