DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and CG9316

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_610051.2	Gene:	CG9316 / 35333	FlyBaseID:	FBgn0032878	Length:	448	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	57/274 - (20%)
Similarity:	93/274 - (33%)	Gaps:	84/274 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1059 SSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAA------------VDPDLWKKMNCSEHK 1111
            :.|||...|.:..::.|            .|.:|::..            :|...::.||.|.::
  Fly   198 TGQNLCGFPNLKTLVLR------------DCLLWNSMEFGIPLKSLHTLDLDDCCFEVMNVSLYQ 250

  Fly  1112 MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQ--------NCPIQAVLA--- 1165
            ..|...|.:|     .||.........    ::|.||.|:..:|:        |.....|||
  Fly   251 KIAESCTNLV-----ELIFSGCDTNFE----VIANLPKLERCTLKTWMTSNELNIGFLTVLAEKR 306

  Fly  1166 ------LH------------TCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLR 1212
                  ||            .||.......||.|       :..|||.         .|......
  Fly   307 GNKLTHLHLSGQFNITNEHARCLGQLSSLTDLRF-------SNNDILD---------DDHFKFFN 355

  Fly  1213 DLKVMKLAGTD----ISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQ-IGTSTTATARLTELN 1272
            ||..::..|..    :.||.:..:.:..|.|:.:||:.|::||:..|.| ||..:..:.|...||
  Fly   356 DLSQLERFGLTACGRVMDVGMMRMLRKCPQLKVIDLTDCEQITEEFVIQAIGFCSKGSGRDVVLN 420

  Fly  1273 LSACRLVSENALEH 1286
            :.. .::....|.|
  Fly   421 VKG-TMIRRPILTH 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	6/46 (13%)
		leucine-rich repeat	1102..1125	CDD:275381	6/22 (27%)
		leucine-rich repeat	1126..1149	CDD:275381	4/22 (18%)
		leucine-rich repeat	1150..1173	CDD:275381	10/51 (20%)
		AMN1	1166..>1320	CDD:187754	32/138 (23%)
		leucine-rich repeat	1174..1213	CDD:275381	7/38 (18%)
		leucine-rich repeat	1214..1238	CDD:275381	4/27 (15%)
		leucine-rich repeat	1239..1267	CDD:275381	10/28 (36%)
		leucine-rich repeat	1268..1292	CDD:275381	4/19 (21%)
		leucine-rich repeat	1293..1317	CDD:275381
CG9316	NP_610051.2	leucine-rich repeat	208..221	CDD:275381	3/24 (13%)
		leucine-rich repeat	231..258	CDD:275381	5/26 (19%)
		leucine-rich repeat	259..279	CDD:275381	5/28 (18%)
		leucine-rich repeat	280..309	CDD:275381	6/28 (21%)
		AMN1	310..>411	CDD:187754	27/116 (23%)
		leucine-rich repeat	310..334	CDD:275381	4/23 (17%)
		leucine-rich repeat	335..359	CDD:275381	9/39 (23%)
		leucine-rich repeat	360..385	CDD:275381	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900